DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ocrl and Inpp5e

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_149125.1	Gene:	Inpp5e / 64436	MGIID:	1927753	Length:	647	Species:	Mus musculus

Alignment Length:	366	Identity:	103/366 - (28%)
Similarity:	174/366 - (47%)	Gaps:	65/366 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 SEYIVYKDIIIYCATWNVNNKTCSDSNNPLRAWLACSEK--PPDIYAIGLQELDTPTKAMLNSTQ 239
            :.|...:::.::.||||:..:  .:....|..:|..:|.  ..|:|.||:||..:.
Mouse   294 ARYFPDRNMALFVATWNMQGQ--KELPASLDEFLLPTEADYTQDLYVIGIQEGCSD--------- 347

  Fly   240 VQAIEKQWIDKMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGN 304
                .::|..::.:::.|  :|.:|.|.......:::.:|:.|..........:|...|.:.:..
Mouse   348 ----RREWETRLQETLGP--QYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKT 406

  Fly   305 KGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGI------------RFDDGRTISD 357
            ||.:.:|......:..|:.||..:..|.|.||..||:..::.:            |...|...:.
Mouse   407 KGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYSRTIQALALPRNVPDTNPYRSSAGDVTTR 471

  Fly   358 HDHIFWVGDLNYRIQ------EPPGQQRPGPLSDAQTYEL----LLQYDQLRQEMRRGKCFEGYT 412
            .|.:||.||.|:|:.      |...:|:|         |:    |||:|||.:||::|..|.|:.
Mouse   472 FDEVFWFGDFNFRLSGGRVAVEAFLKQKP---------EVDVLALLQHDQLTREMKKGSIFRGFE 527

  Fly   413 EGEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRVLWKGTR---IEQLAYNSIMEIRQSDHKPVYA 474
            |.||.|.|:||:|.|.|.|||:.|||.|:|.||||:|...   |..:.|:|...|:.|||:|||.
Mouse   528 EAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYG 592

  Fly   475 VFQVKVKT-RDEV-----KYKR------VQEEVLKAVDKRE 503
            :|||||:. ||.:     |:.|      ::..:.|.:.::|
Mouse   593 LFQVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQE 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	92/319 (29%)
		RhoGAP_OCRL1	614..823	CDD:239845
Inpp5e	NP_149125.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..80
		PHA03246	<14..166	CDD:223020
		3 X 4 AA repeats of P-X-X-P	52..243
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..131
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..196
		INPP5c_INPP5E-like	298..596	CDD:197329	92/323 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810