DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ocrl and INPP5E

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_063945.2	Gene:	INPP5E / 56623	HGNCID:	21474	Length:	644	Species:	Homo sapiens

Alignment Length:	384	Identity:	101/384 - (26%)
Similarity:	167/384 - (43%)	Gaps:	101/384 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 SEYIVYKDIIIYCATWNVNNKTCSDSNNPLRAWLACSEKPP---------------DIYAIGLQE 226
            :.|...:::.::.||||:..:               .|.||               |:|.||:||
Human   291 ARYFPDRNVALFVATWNMQGQ---------------KELPPSLDEFLLPAEADYAQDLYVIGVQE 340

  Fly   227 LDTPTKAMLNSTQVQAIEKQWIDKMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRP 291
            ..:.             .::|..::.:::.|  .|.:|.|.......:::.:|:.|.........
Human   341 GCSD-------------RREWETRLQETLGP--HYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEC 390

  Fly   292 KSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRTIS 356
            .:|...|.:.:..||.:.||......:..|:.||..:..|.|.||..||...|:.:...  |.:.
Human   391 STVTTRIVSQIKTKGALGISFTFFGTSFLFITSHFTSGDGKVAERLLDYTRTVQALVLP--RNVP 453

  Fly   357 D--------------HDHIFWVGDLNYRIQEPPGQQRPGPLSDAQT-------------YELLLQ 394
            |              .|.:||.||.|:|            ||..:|             ...|||
Human   454 DTNPYRSSAADVTTRFDEVFWFGDFNFR------------LSGGRTVVDALLCQGLVVDVPALLQ 506

  Fly   395 YDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRVLWKGTR---IEQL 456
            :|||.:|||:|..|:|:.|.:|.|.|:||:|.|.|.|||:.|||.|:|.||||::...   |..:
Human   507 HDQLIREMRKGSIFKGFQEPDIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYRSRHKGDICPV 571

  Fly   457 AYNSIMEIRQSDHKPVYAVFQVKVKT-RDEV-----KYKR------VQEEVLKAVDKRE 503
            :|:|...|:.|||:|||.:|:|||:. ||.:     |:.|      ::..:.|.:.:::
Human   572 SYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRELYLLGIKRRISKEIQRQQ 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	92/337 (27%)
		RhoGAP_OCRL1	614..823	CDD:239845
INPP5E	NP_063945.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..193
		PHA03247	<2..179	CDD:223021
		13 X 4 AA repeats of P-X-X-P	10..242
		INPP5c_INPP5E-like	295..593	CDD:197329	92/341 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810