Protein Alignment Ocrl and inpp5b

DIOPT Version :10

• Sequence 1: NP_569962.2
• Gene: Ocrl / 31157
• FlyBaseID: FBgn0023508
• Length: 850
• Species: Drosophila melanogaster
• Sequence 2: XP_009290335.3
• Gene: inpp5b / 563543
• ZFINID: ZDB-GENE-110411-228
• Length: 907
• Species: Danio rerio
• Alignment Length: 899
• Identity: 272/899 - (30%)
• Similarity: 431/899 - (47%)
• Gaps: 150/899 - (16%)

  Fly    24 VKERFKEDETIEYIFEAYQIKGPEYSNRLLALVSSQSGGTFAIIAFSYLRTPLSSANELIINKVF 88
            ::|...|.|:.....|...:......::|:.||  :.....|:..:|:.|..: :..::.:.::.
Zfish     7 IQETLAEGESCTIAVECVSLLNDVRDSKLIGLV--RQNKEHALFIYSHRRMAI-TGEDVTLGQII 68

  Fly    89 AIDHNFQLRQ------------DSKSSITTQQFDLSTAEDGPIKYYYYATESHHYEEFVAKVISF 141
            .|.::|.:.:            |::..:|..:.:|.      :|..:    ..|...|:::|...
Zfish    69 PISYDFSVVEVSSPDELAVVGADTRVRVTFLEEELE------LKLPF----GSHTRLFLSEVNRA 123

  Fly   142 KSTMAQHDPETVLNFRWLNDYRQI----------------------------------------- 165
            .|.:.|..|:....|.||..||::
Zfish   124 WSDVCQQYPKEEPKFDWLTKYRKVSKGARSLRKSIGATTVKMSQMKKAERAHTANSSALKKEDES 188

  Fly   166 -------------GEVKQ-------------------------------ELKKRESEYIVYKDII 186
                         ||||.                               ||.|.|..|...::..
Zfish   189 ARGDALQSQEKVKGEVKDDLIRNSQPVLSNKAQMLGMPQFGLRDNLIKCELLKNEDAYTYIENYS 253

  Fly   187 IYCATWNVNNKTCSDSNNPLRAWLACSEKPPDIYAIGLQELDTPTKAML-NSTQVQAIEKQWIDK 250
            .:..|:|||.:|..:|.:|   |||.:..|||.|.||.||||...:|.| |.|..   |.:|:..
Zfish   254 FFLGTYNVNGQTPKESLSP---WLASTASPPDFYLIGFQELDLSKEAFLFNDTPK---EPEWMLA 312

  Fly   251 MMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQLN 315
            :...:|||.:|.::...|||..||...|:.:...||.....::|..|:...:||||.|:|..|.:
Zfish   313 VYKGLHPDAKYALVKLVRLVGIMLLFYVKAEHAPHISEVEAETVGTGVMGRMGNKGAVSIRFQFH 377

  Fly   316 EGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRF--DDGR----TISDHDHIFWVGDLNYRIQEP 374
            ..:||.||||||||....|.||||:..|...|:|  :|..    ||..|:.:.|:|||||||.:.
Zfish   378 NSDICVVNSHLAAHTEEFERRNQDFKDICRRIQFRQEDPTLPPLTILKHNIVLWLGDLNYRISDL 442

  Fly   375 PGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRA 439
            . ......|...:.:|.|..||||:::|.....|.|:|||||.|:||||||.|:|.:|:|||.|.
Zfish   443 E-VDHVKDLISKKDFETLHTYDQLKRQMDEEVVFVGFTEGEIDFQPTYKYDTGSDQWDTSEKCRV 506

  Fly   440 PAYCDRVLWKGTRIEQLAYNSIMEIRQSDHKPVYAVFQVKVKTRDEVKYKRVQEEVLKAVDKREN 504
            ||:|||:||:|..|:||.|.|.|.::.||||||.::.::.:|..:|..|||..||:::.:|:.||
Zfish   507 PAWCDRILWRGKSIKQLHYQSHMTLKTSDHKPVSSLLEIGIKVVNEESYKRTFEEIVRQIDRLEN 571

  Fly   505 DNQPQINVEKTVIDFGTVRFNEPSTRDFNVYNNCPLPVDFSFKEK-DIHAICEPWLHVDPRQDSL 568
            |..|.:::.:....|..|:|.:...|...|:|:..:|..|.|.:| |..|.|:|||..:|.:..|
Zfish   572 DCIPSVSLSEREFHFQDVKFMQHQARTVTVHNDGQVPCQFEFIQKLDEPAYCKPWLTANPAKGFL 636

  Fly   569 LIDSARSIRLKMNANVRTIAGLLRKIRASDNFDILILHVENGRDIFITVTGDYQPSCFGLSMETM 633
            ...::..|.|::..|..|...|...::..:  |||:||:|.|:|.||::||.|.|||||.|:..:
Zfish   637 AQGASVDIDLEVFVNRHTAPELNAGLQQLE--DILVLHLERGKDYFISITGSYLPSCFGSSLSAL 699

  Fly   634 CRTDRPLSEYSQDQIKQL-MNDESP-----EYRVTMPREFFLLIDYLYRQGSKQVGAFPSYDSRL 692
            |....|:.:...:.|::| :...||     :....:|:|.::::|:|:|...||...|    .:.
Zfish   700 CLLREPIQDMPLESIRELSVKSNSPVIDSADKPQEIPKEIWMMVDHLFRYAKKQEDLF----QQP 760

  Fly   693 SLGAQFNSVRDWLDTWSDDPFPANAETAAQALLLLLDLPEHALLEPVV-----ENLLE-CTNKSQ 751
            .|.::|..:||.|||...|..|.:..:.|:||||.||    ||.|||:     :..|: |::.|.
Zfish   761 GLRSEFEEIRDCLDTGCLDTLPGSNHSVAEALLLFLD----ALPEPVIPFSFYQQCLDCCSDSSH 821

  Fly   752 AMDYISLLSPPKRNVFMHLCMFLRAGIESQFY---DLHQVASTFGRILLRSTER 802
            ....||:|....:|||.:|..||:..:....|   |::.||..|..:||||.::
Zfish   822 CRQIISMLPQCHKNVFNYLTAFLQELLRHSAYNRLDVNVVAPIFAGLLLRSPDK 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_569962.2	INPP5B_PH	23..160	CDD:465268	24/147 (16%)
		INPP5c_INPP5B	185..478	CDD:197327	126/299 (42%)
		RhoGAP_OCRL1	614..823	CDD:239845	67/204 (33%)
inpp5b	XP_009290335.3	INPP5B_PH	1..143	CDD:465268	25/148 (17%)
		INPP5c_INPP5B	253..545	CDD:197327	126/298 (42%)
		PapD-like	574..>648	CDD:373355	21/73 (29%)
		RhoGAP_OCRL1	680..892	CDD:239845	67/204 (33%)