DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ocrl and Inpp5d

DIOPT Version :9

Sequence 1:NP_001259153.1 Gene:Ocrl / 31157 FlyBaseID:FBgn0023508 Length:850 Species:Drosophila melanogaster
Sequence 2:NP_062184.2 Gene:Inpp5d / 54259 RGDID:2914 Length:1190 Species:Rattus norvegicus


Alignment Length:726 Identity:171/726 - (23%)
Similarity:282/726 - (38%) Gaps:235/726 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 ETIEYIFEAYQIKG----PEYSNRLLALVSSQSGGTFAIIAFSYLRTPLSSANELIINKVFAIDH 92
            |:::.:|:.....|    |:        |..::.....:...|.|.:.|||    |.:||.|:.|
  Rat   234 ESLQRLFDQQLSPGLRPRPQ--------VPGEANPITMVAKLSQLTSLLSS----IEDKVKALLH 286

  Fly    93 ---------------NFQLRQDS---------KSSITTQQFDLSTAEDGPIKYYYYATESH---- 129
                           .|:::.:|         |..:.:.:..:..:.||....:|    ||    
  Rat   287 EGSESTNRRSLIPPVTFEVKSESLGIPQKMHLKVDVESGKLIIKKSRDGSEDKFY----SHKKIL 347

  Fly   130 ---HYEEFVAKVISFKSTMAQHDPETVLNFRWL-NDYRQ---IGEVKQELKKRESEYIVYKDIII 187
               ..::|:.|::    .:.:.:.|.:|...:: :|.::   ..::.|::|.:.||......|.|
  Rat   348 QLIKSQKFLNKLV----ILVETEKEKILRKEYVFSDSKKREGFCQLLQQMKNKHSEQSEPDMITI 408

  Fly   188 YCATWNVNN-----------------KTCSDSNNPLRAWLACSEKPPDIYAIGLQELDTPTKAML 235
            :..|||:.|                 ||..||.:.:         |.|||.||.||  .|..   
  Rat   409 FIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYI---------PHDIYVIGTQE--DPLG--- 459

  Fly   236 NSTQVQAIEKQWIDKMMDSVH--PDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGI 298
                    ||:|::.:..|:.  ..:.::.:..|.|....:.|:.:.:....|......:|..||
  Rat   460 --------EKEWLEILRHSLQEVTSMTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGI 516

  Fly   299 FNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRTISDHD---- 359
            .|||||||.|.:|...|..::.||||||.:.......|||:|..|:..:...| :.:|..:    
  Rat   517 ANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGD-KKLSPFNITHR 580

  Fly   360 --HIFWVGDLNYRIQEPPGQQRPGPLSDA-------QTYELLLQYDQLRQEMRRGKCFEGYTEGE 415
              |:||:||||||::.|..:      ::|       |.|..||.:|||..|.:..|.|..:.|.|
  Rat   581 FTHLFWLGDLNYRVELPTWE------AEAIIQKIKQQQYSDLLAHDQLLLERKEQKVFLHFEEEE 639

  Fly   416 IKFRPTYKYDPGTDNYDSSEKQRA-------PAYCDRVLWKGTRIEQL---AYNSIMEIRQSDHK 470
            |.|.|||:::..|.:..:..||:|       |::|||||||...:..:   :|.|..:|..|||.
  Rat   640 ITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHS 704

  Fly   471 PVYAVFQVKV----------------------------KTRDEVK-YKRVQEEVLKA-VDKREND 505
            ||:|.|:..|                            ||:.:.| |..:....|:: |..:|.:
  Rat   705 PVFATFEAGVTSQFVSKNGPGAVDSQGQIEFLACYATLKTKSQTKFYLELHSSCLESFVKSQEGE 769

  Fly   506 NQPQINVEKTVIDFG--TVRFNEPSTRDFNVYNNCPLPVDFSFKEKDIHAICEPWLHVDPRQDSL 568
            |:..        |.|  .|||.|            .||     |.|.|  |.:|         ..
  Rat   770 NEEG--------DEGELVVRFGE------------TLP-----KLKPI--ISDP---------EY 798

  Fly   569 LIDSARSIRLKMNANVRTIAGLLRKIRASDNFDILILHVENGRDIFITVTGDYQPSCFGLSMETM 633
            |:|.                .:|..|::||:.:                  .|...|..|.:|| 
  Rat   799 LLDQ----------------HILISIKSSDSDE------------------SYGEGCIALRLET- 828

  Fly   634 CRTDRPLSEYS 644
              |:..|..|:
  Rat   829 --TESQLPIYT 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OcrlNP_001259153.1 PH-like 23..163 CDD:302622 28/166 (17%)
INPP5c_INPP5B 185..478 CDD:197327 103/334 (31%)
RhoGAP_OCRL1 614..823 CDD:239845 8/31 (26%)
Inpp5dNP_062184.2 SH2_SHIP 4..105 CDD:198206
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..130
SH3-binding 1 126..131
INPP5c_SHIP1-INPP5D 406..712 CDD:197334 103/334 (31%)
NPXY motif 1 914..917
PTZ00449 <930..>1132 CDD:185628
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 946..1190
SH3-binding 2 969..974
Interaction with DAB2. /evidence=ECO:0000250 1014..1028
NPXY motif 2 1017..1020
SH3-binding 3 1038..1049
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5411
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.