DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and INPP5K

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_057616.2	Gene:	INPP5K / 51763	HGNCID:	33882	Length:	448	Species:	Homo sapiens

Alignment Length:	496	Identity:	130/496 - (26%)
Similarity:	196/496 - (39%)	Gaps:	126/496 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 IYCATWNVNNKTCSDSNNPLRAWLACSEKPP----------------DIYAIGLQELDTPTKAML 235
            |:..||||                 .|..||                |||.||||||::...::|
Human    16 IHVVTWNV-----------------ASAAPPLDLSDLLQLNNRNLNLDIYVIGLQELNSGIISLL 63

  Fly   236 NSTQVQAIEKQWIDKMMDSVHPDVEYEILMSH-RLVATMLTVIVRKQLRQHIIRCRPKSVARGIF 299
            :..   |....|...:||.:.| :.: |.:|| |:...:|.|..:.|...:|.....||...|:|
Human    64 SDA---AFNDSWSSFLMDVLSP-LSF-IKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLF 123

  Fly   300 NTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGR---TISDHDHI 361
            ...||||||.|.|:|....:..:|.||..|:....:|.:.::.|:| ::..:||   .|.|||.|
Human   124 GYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFDRILE-MQNCEGRDIPNILDHDLI 187

  Fly   362 FWVGDLNYRIQEPPGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDP 426
            .|.||:|:|| |..|..........:.|..|.:.|||....:.......:.||.:.|.||||:|.
Human   188 IWFGDMNFRI-EDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDR 251

  Fly   427 GTDNYDSSEKQRAPAYCDRVLWKGTR-----------------IEQLAYNSIMEIRQSDHKPVYA 474
            .:::||:|||:|.||:.||:||:..|                 :....|:|.|....||||||..
Human   252 NSNDYDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSG 316

  Fly   475 VFQVKVKTRDEVKYKRVQEEVLKAVDKRENDNQPQINVEKTVIDFGT-----VRFNEPSTRDFNV 534
            .|.:::|.........:..|.|..|   |||.....:   :..||.:     :...:...||.|.
Human   317 TFDLELKPLVSAPLIVLMPEDLWTV---ENDMMVSYS---STSDFPSSPWDWIGLYKVGLRDVND 375

  Fly   535 YNNCPLPVDFSFKEKDIHAICEPWLHVDPRQDSLLIDSARSIRLKMNANVRTIAGLLRKIRASDN 599
            |                  :...|:.          ||                    |:..|||
Human   376 Y------------------VSYAWVG----------DS--------------------KVSCSDN 392

  Fly   600 FDILILHVENGRDIFITVTGDYQPSC-FGLSMETMCRTDRP 639
            .:.:.:.:.|     |..|.|....| :..|:.::....||
Human   393 LNQVYIDISN-----IPTTEDEFLLCYYSNSLRSVVGISRP 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	102/327 (31%)
		RhoGAP_OCRL1	614..823	CDD:239845	7/27 (26%)
INPP5K	NP_057616.2	EEP	14..320	CDD:382041	102/327 (31%)
		Catalytic. /evidence=ECO:0000255	16..318		101/325 (31%)
		Required for interaction with GPR78 and PAK1. /evidence=ECO:0000269\|PubMed:26940976	318..448		29/170 (17%)
		Required for ruffle localization	321..448		28/167 (17%)
		SKICH	331..431	CDD:375315	27/157 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810