DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and OCRL

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001305713.1	Gene:	OCRL / 4952	HGNCID:	8108	Length:	902	Species:	Homo sapiens

Alignment Length:	921	Identity:	269/921 - (29%)
Similarity:	419/921 - (45%)	Gaps:	166/921 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ETIEYIFEAYQIKGPEYSNRLLALVSSQSGGTFAIIAFSYLRTPLSSANELIINKVFAIDHNFQL 96
            :.:.:..|..::|||  .....||..:|..|.:.:|...:       ..|..:..:..|:.:|:.
Human    10 QPLAHTVEGMEMKGP--LREPCALTLAQRNGQYELIIQLH-------EKEQHVQDIIPINSHFRC 65

  Fly    97 RQDSKSSITTQQFDLSTAEDGPIKYY--------YYATESHHYEEFVAKVISFKSTMAQ------ 147
            .|:::.::.   .|:::.....|:..        :...:..|..:|::.|::.:...:|
Human    66 VQEAEETLL---IDIASNSGCKIRVQGDWIRERRFEIPDEEHCLKFLSAVLAAQKAQSQLLVPEQ 127

  Fly   148 ------------HDPETVL--------NFRWLNDYRQI--------------------------- 165
                        .|..:|.        ||..:|..::|
Human   128 KDSSSWYQKLDTKDKPSVFSGLLGFEDNFSSMNLDKKINSQNQPTGIHREPPPPPFSVNKMLPRE 192

  Fly   166 -----------------------------GEVKQELKKRESEYIVYKDIIIYCATWNVNNKTCSD 201
                                         |.:|..|.|||.||:..:....:..|||||.:: .|
Human   193 KEASNKEQPKVTNTMRKLFVPNTQSGQREGLIKHILAKREKEYVNIQTFRFFVGTWNVNGQS-PD 256

  Fly   202 SNNPLRAWLACSEKPPDIYAIGLQELDTPTKAMLNSTQVQAIEKQWIDKMMDSVHPDVEYEILMS 266
            |.  |..||.|...|||||.||.||||..|:|......|:  |::|...:...:|...:|:.:..
Human   257 SG--LEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVK--EQEWSMAVERGLHSKAKYKKVQL 317

  Fly   267 HRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMG 331
            .|||..||.:..||...::|.....::|..||...:|||||||:....:....|.||||||||:.
Human   318 VRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVE 382

  Fly   332 YVEERNQDYNAIVEGIRF-DDGRT-----ISDHDHIFWVGDLNYRIQEPPGQQRPGPLSDAQTYE 390
            ..|.|||||..|...:.| ...:|     |..|:.:.|:||||||:..|...:... |.:.:..:
Human   383 DFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKS-LINKKDLQ 446

  Fly   391 LLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRVLWKGTRIEQ 455
            .||::|||..:..:.|.|..:.||||||.||||||..||.:|||.|.|.||:|||:||:||.:.|
Human   447 RLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGTNVNQ 511

  Fly   456 LAYNSIMEIRQSDHKPVYAVFQVKVKTRDEVKYKRVQEEVLKAVDKRENDNQPQINVEKTVIDFG 520
            |.|.|.||::.||||||.|:|.:.||..||.:|::|.|:.::.:|:.|||..|.:.:.:....|.
Human   512 LNYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDSVRIMDRMENDFLPSLELSRREFVFE 576

  Fly   521 TVRFNEPSTRDFNVYNNCPLPVDFSFKEK-DIHAICEPWLHVDPRQDSLLIDSARSIRLKMNANV 584
            .|:|.:.....|.:.||..:|..|||..| :....|:|||..:|.:..|..:....|.|.:..:.
Human   577 NVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDSQYCKPWLRAEPFEGYLEPNETVDISLDVYVSK 641

  Fly   585 RTIAGLLR---KIRASDNFDILILHVENGRDIFITVTGDYQPSCFGLSMETMCRTDRPLSEYSQD 646
            .::..|..   ||.     |||:||::.|:|.|:|::|:|.|||||.|:|.:||..||:.|....
Human   642 DSVTILNSGEDKIE-----DILVLHLDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVT 701

  Fly   647 QIKQLMNDE-----------------SPEYRVTMPREFFLLIDYLYRQGSKQVGAF--PSYDSRL 692
            ::..|..|.                 :.|..:.:|:|.:||:|:|::....|...|  |.....|
Human   702 KLIDLEEDSFLEKEKSLLQMVPLDEGASERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEEL 766

  Fly   693 SLGAQFNSVRDWLDTWSDDPFPANAETAAQALLLLLDLPEHALLEPVV--ENLLECTNKSQ---- 751
                  ..:.|.|||...:..|.:..:.|:|||:.|:    ||.|||:  |....|.:.:.
Human   767 ------QQIIDCLDTSIPETIPGSNHSVAEALLIFLE----ALPEPVICYELYQRCLDSAYDPRI 821

  Fly   752 AMDYISLLSPPKRNVFMHLCMFLRAGIESQFY---DLHQVASTFGRILLRS----TERAAWMDYH 809
            ....||.|....||||.:|..|||..::...|   :.:.:|:.|..:|||.    ..|....| .
Human   822 CRQVISQLPRCHRNVFRYLMAFLRELLKFSEYNSVNANMIATLFTSLLLRPPPNLMARQTPSD-R 885

  Fly   810 SRCIQFMRLFI 820
            .|.|||:..|:
Human   886 QRAIQFLLGFL 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	24/164 (15%)
		INPP5c_INPP5B	185..478	CDD:197327	125/298 (42%)
		RhoGAP_OCRL1	614..823	CDD:239845	70/239 (29%)
OCRL	NP_001305713.1	PH_OCRL1	15..116	CDD:270182	18/112 (16%)
		Clathrin box 1	74..78		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..188		1/22 (5%)
		5-phosphatase	238..564		136/331 (41%)
		INPP5c_INPP5B	241..534	CDD:197327	125/298 (42%)
		ASH	565..679		33/118 (28%)
		RhoGAP_OCRL1	669..897	CDD:239845	70/239 (29%)
		Clathrin box 2	703..707		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I2444
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H233
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1900
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54104
OrthoDB	1	1.010	-	-		D129921at33208
OrthoFinder	1	1.000	-	-		FOG0002633
OrthoInspector	1	1.000	-	-		otm41762
orthoMCL	1	0.900	-	-		OOG6_101357
Panther	1	1.100	-	-	LDO	PTHR11200
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840