DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ocrl and INPP5E

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001261753.1	Gene:	INPP5E / 39404	FlyBaseID:	FBgn0036273	Length:	747	Species:	Drosophila melanogaster

Alignment Length:	355	Identity:	109/355 - (30%)
Similarity:	159/355 - (44%)	Gaps:	80/355 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 SEYIVYKDIIIYCATWNVNN----KTCSDSNNPLRAWLACSEKPPDIYAIGLQELDTPTKAMLNS 237
            |..:..|:|.::..|||:|.    |..:|...|     |..|..|||..:|.|| .||.:.
  Fly   383 SRVLPQKEITVFVGTWNMNGHSPPKQLNDFVLP-----ANVEHVPDIVVMGTQE-STPDRF---- 437

  Fly   238 TQVQAIEKQWIDKMMDSVHPDVEYEILMSHRLVATM-LTVIVRKQLRQHIIRCR-PKSVARGI-- 298
                    :|...:.:::.|.   .:|.....:.|: |.|.:|:.|   |..|. |:..:..:
  Fly   438 --------EWEVTIQETLGPS---HVLFHATTLGTLHLAVYMRRDL---IWYCSVPEDASMSVRT 488

  Fly   299 ---FNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGI---------RFDD 351
               |.|   ||.||||..|...::.||.|||.||...|:||..|...|:..:         |..:
  Fly   489 GSAFRT---KGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKN 550

  Fly   352 GRTISDHDHIFWVGDLNYRIQEP--------PGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCF 408
            .....:.|::||.||||:|:.||        ...:.|.|......|   :..|||...:..|..|
  Fly   551 KDVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGY---MHTDQLTSVLADGAAF 612

  Fly   409 EGYTEGEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRVLWK----------------------GT 451
            .|:.|..|.|.||||||||:.|:|:|.|||||||.||:|:|                      ..
  Fly   613 RGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQP 677

  Fly   452 RIEQLAYNSIMEIRQSDHKPVYAVFQVKVK 481
            .::.|.|:|:..|..||||||:|:|:..::
  Fly   678 HVQCLLYDSVPSITTSDHKPVWALFRTLIR 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	107/342 (31%)
		RhoGAP_OCRL1	614..823	CDD:239845
INPP5E	NP_001261753.1	EEP	387..703	CDD:321002	107/345 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1399831at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750