Protein Alignment Ocrl and INPPL1

DIOPT Version :9

• Sequence 1: NP_001259153.1
• Gene: Ocrl / 31157
• FlyBaseID: FBgn0023508
• Length: 850
• Species: Drosophila melanogaster
• Sequence 2: XP_024304269.1
• Gene: INPPL1 / 3636
• HGNCID: 6080
• Length: 1324
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 113/465 - (24%)
• Similarity: 176/465 - (37%)
• Gaps: 154/465 - (33%)

  Fly   167 EVKQELKKRESEYIVYKDIIIYCATWNVNN-----------------KTCSDSNNPLRAWLACSE 214
            ::.|.:|.:.|:......|.::..|||:.:                 ||..:....:
Human   428 QLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTI-------- 484

  Fly   215 KPPDIYAIGLQELDTPTKAMLNSTQVQAIEKQWIDKMMDSVH--PDVEYEILMSHRLVATMLTVI 277
             |.|||..|.||         ||..    :::|:|.:...:.  .|::|..:....|....:.|:
Human   485 -PHDIYVFGTQE---------NSVG----DREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVL 535

  Fly   278 VRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNA 342
            |:.:....|......||..||.|||||||.|.:|...|..:..|||.||.:.......|||:|..
Human   536 VKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLD 600

  Fly   343 IVEGIRFDDGRTISDHD------HIFWVGDLNYRIQEPPGQQRPGPLSDAQ---------TYELL 392
            |:..:...| |.::..|      |:||.||||||:.           .|.|         .:|.|
Human   601 ILRLLSLGD-RQLNAFDISLRFTHLFWFGDLNYRLD-----------MDIQEILNYISRKEFEPL 653

  Fly   393 LQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQR-------APAYCDRVLWKG 450
            |:.|||..|..:.|.|..::|.||.|.|||:|:.|:.:..:..||:       .|::|||:|||.
Human   654 LRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKS 718

  Fly   451 TRIEQLAYNS--------IM---------------------------------------EIRQSD 468
            .....:..||        :|                                       :|..||
Human   719 YPETHIICNSYGQSLPDRVMGDLGWSPSGLCPNLGRWEPRVGIFPLSPHSYPLSPGCTDDIVTSD 783

  Fly   469 HKPVYAVFQVKV-----------KTRDE--VKYKRVQEEVLKAVDKR------------------ 502
            |.||:..|:|.|           ||.|:  ::::.: |.::|...:.
Human   784 HSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESI-EAIVKTASRTKFFIEFYSTCLEEYKKSF 847

  Fly   503 ENDNQPQINV 512
            |||.|...|:
Human   848 ENDAQSSDNI 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	98/380 (26%)
		RhoGAP_OCRL1	614..823	CDD:239845
INPPL1	XP_024304269.1	SH2_SHIP	17..119	CDD:198206
		EEP	446..793	CDD:321002	98/380 (26%)
		Atrophin-1	<965..1280	CDD:331285
		SAM_Ship2	1260..1322	CDD:188890

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810