DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and INPP5B

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001352749.1	Gene:	INPP5B / 3633	HGNCID:	6077	Length:	913	Species:	Homo sapiens

Alignment Length:	911	Identity:	278/911 - (30%)
Similarity:	443/911 - (48%)	Gaps:	166/911 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VKERFKEDETIEYIFEAYQIKGPEYSNRLLALVS---SQSGGTFAIIAFSYLRTPLSSANELIIN 85
            ::|...|.|......:....:|....:|||.||.   ...|...|:..:::.|..: :.:::.::
Human     7 IQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAI-TGDDVSLD 70

  Fly    86 KVFAIDHNFQLRQDSK--------SSITTQQFDLSTAEDGPIKYYYYATESHHYEEFVAKVI-SF 141
            ::..:..:|.|.:.|.        |.:|.|   |.|||...:....:.:::..:...||:.. .|
Human    71 QIVPVSRDFTLEEVSPDGELYILGSDVTVQ---LDTAELSLVFQLPFGSQTRMFLHEVARACPGF 132

  Fly   142 KSTMAQHDPETVLNFRWLNDYR-------------------------QIGE-------------- 167
            .|  |..|||    |.||:.||                         .||.
Human   133 DS--ATRDPE----FLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGGSNFDGLRPNGKG 191

  Fly   168 --------------------------------------------------------VKQELKKRE 176
                                                                    ||..|.::|
Human   192 VPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKE 256

  Fly   177 SEYIVYKDIIIYCATWNVNN---KTCSDSNNPLRAWLACSEKPPDIYAIGLQELDTPTKAMLNST 238
            .:|...::...:..|:|||.   |.|      ||.||:...:.||:|.:|.||||...:|.....
Human   257 EDYTYIQNFRFFAGTYNVNGQSPKEC------LRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHD 315

  Fly   239 QVQAIEKQWIDKMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLG 303
            ..:  |::|...:.:.:|||.:|..:...|||..||.:.|:::...:|.....::|..||...:|
Human   316 TPK--EEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMG 378

  Fly   304 NKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRF---DDG---RTISDHDHIF 362
            |||||||..|.:..:||.||||||||:...|.|||||..|...::|   |..   .|||:||.|.
Human   379 NKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVIL 443

  Fly   363 WVGDLNYRIQEPPGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPG 427
            |:|||||||:| ...::...|.:.:.:::|..||||:.::.....|||:||||:.|:||||||.|
Human   444 WLGDLNYRIEE-LDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTG 507

  Fly   428 TDNYDSSEKQRAPAYCDRVLWKGTRIEQLAYNSIMEIRQSDHKPVYAVFQVKVKTRDEVKYKRVQ 492
            :|::|:|||.||||:|||:||||..|.||:|.|.|.::.||||||.:||.:.|:..::..|::..
Human   508 SDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTL 572

  Fly   493 EEVLKAVDKRENDNQPQINVEKTVIDFGTVRFNEPSTRDFNVYNNCPLPVDFSFKEK-DIHAICE 556
            ||:::::||.||.|.|.:::.|....|..|::.:.....|.::|. .:|..|.|..| |..:.|:
Human   573 EEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNG-QVPCHFEFINKPDEESYCK 636

  Fly   557 PWLHVDPRQDSLLIDSARSIRLKMNANVRTIAGLLRKIRASDN--FDILILHVENGRDIFITVTG 619
            .||:.:|.:..||.||...|.|::..|..|..    |:.:.::  .|||:||::.|:|.|::|:|
Human   637 QWLNANPSRGFLLPDSDVEIDLELFVNKMTAT----KLNSGEDKIEDILVLHLDRGKDYFLSVSG 697

  Fly   620 DYQPSCFGLSMETMCRTDRPLSEYSQDQIKQLM-------ND----ESPEYRVTMPREFFLLIDY 673
            :|.|||||..:.|:|....|:.:...:.|.:|.       :|    :||   :.:|:|.::::||
Human   698 NYLPSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSP---MEIPKELWMMVDY 759

  Fly   674 LYRQGSKQVGAFPSYDSRLSLGAQFNSVRDWLDTWSDDPFPANAETAAQALLLLLD-LPEHALLE 737
            |||...:|...|    .:..|.::|..:||.|||...|...|:..:.|:||||.|: |||..:..
Human   760 LYRNAVQQEDLF----QQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICY 820

  Fly   738 PVVENLLECT-NKSQAMDYISLLSPPKRNVFMHLCMFLRAGIES---QFYDLHQVASTFGRILLR 798
            ....|.|||: |.:.:...||.|....:|||.:|..|||..:::   ...|.:.:||.||.:|||
Human   821 STYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSLLLR 885

  Fly   799 S 799
            :
Human   886 N 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	33/150 (22%)
		INPP5c_INPP5B	185..478	CDD:197327	129/301 (43%)
		RhoGAP_OCRL1	614..823	CDD:239845	67/202 (33%)
INPP5B	NP_001352749.1	INPP5B_PH	6..150	CDD:318889	35/152 (23%)
		INPP5c_INPP5B	265..558	CDD:197327	129/301 (43%)
		RhoGAP_OCRL1	692..912	CDD:239845	67/202 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141864
Domainoid	1	1.000	231	1.000	Domainoid score	I2444
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1900
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54104
OrthoDB	1	1.010	-	-		D129921at33208
OrthoFinder	1	1.000	-	-		FOG0002633
OrthoInspector	1	1.000	-	-		otm41762
orthoMCL	1	0.900	-	-		OOG6_101357
Panther	1	1.100	-	-	O	PTHR11200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3488
SonicParanoid	1	1.000	-	-		X494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800