Protein Alignment Ocrl and inppl1a

DIOPT Version :10

• Sequence 1: NP_569962.2
• Gene: Ocrl / 31157
• FlyBaseID: FBgn0023508
• Length: 850
• Species: Drosophila melanogaster
• Sequence 2: XP_073778854.1
• Gene: inppl1a / 325179
• ZFINID: ZDB-GENE-030131-3904
• Length: 1274
• Species: Danio rerio
• Alignment Length: 875
• Identity: 205/875 - (23%)
• Similarity: 346/875 - (39%)
• Gaps: 235/875 - (26%)

  Fly     1 MDTLSEAVANGTATAATRTTKDIVKERFKE--DETIEYIFEAYQIKGPEYSN---RLLALVSSQS 60
            ::.||:.....:|:..:|    ::::...:  |:.:|::.....|.....|:   :.|..:...|
Zfish   221 LEILSKVFDQQSASMVSR----MIQQSMSQGGDQELEHLVTKLAILKDLLSSIEKKALKALQDMS 281

  Fly    61 GGTFAIIAFSYLRTPLSSANELIINKVFAIDHNFQLRQDSKSSITT-----QQFDLST-AEDGPI 119
            ..|.||       :||.|    |.|||..: ..|:::.|...:..|     |::.||. .|.|.:
Zfish   282 SSTPAI-------SPLLS----IRNKVIPV-QTFEVKLDVYLADLTKIGKSQKYSLSVDVEGGKL 334

  Fly   120 KYYYYATESHHYEEFVAKVISFKSTMAQHDPETVLNFRWLNDYRQ----------IGEV--KQEL 172
                              |:..|...||.|..|..:    :..||          :|.|  |::.
Zfish   335 ------------------VVMKKMKDAQEDWNTFTH----DKIRQLIKSQRVQNKLGIVFEKEKD 377

  Fly   173 KKRESEYI---------------VYKD----------IIIYCATWNVNNKTCSDSNNPLRAWL-- 210
            |.:..::|               :.|:          |.|:..|||:.:   ..:..||.:|:
Zfish   378 KSQRKDFIFASAKKREAFCQLLQLMKNKHSNQDEPDMISIFIGTWNMGS---VPAPKPLGSWILS 439

  Fly   211 -----ACSEK----PPDIYAIGLQELDTPTKAMLNSTQVQAIEKQWIDKMMDSV--HPDVEYEIL 264
                 ...|.    |.|||..|.||         ||    ..:|:|::.:..|:  :.|:||:.:
Zfish   440 RGLGKTLDEMAVTIPHDIYVFGTQE---------NS----VCDKEWVETLRCSLKEYTDMEYKPI 491

  Fly   265 MSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAH 329
            ....|....:.|:|:.:....|......||..||.|||||||.|.:|...|..:..|||.||.:.
Zfish   492 AVQTLWNIKIVVLVKAEHENRISHVGMSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSG 556

  Fly   330 MGYVEERNQDYNAIVEGIRFDDGRTISDHD------HIFWVGDLNYR----IQEPPGQQRPGPLS 384
            ...:..|||:|..|:..:...| :.::..|      |:||.||||||    |||...      ..
Zfish   557 NEKIHRRNQNYLDILRQLSLGD-KQLNSFDISLRFTHLFWFGDLNYRLDMDIQEILN------YI 614

  Fly   385 DAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRA-------PAY 442
            :.:.::.||:.|||..|..:.|.|..:.|.||.:.|||:|:.|:.:....:||:|       |::
Zfish   615 NRKEFDPLLKVDQLNLEREKNKIFLRFAEEEISYPPTYRYERGSRDTYVWQKQKATGMRTNVPSW 679

  Fly   443 CDRVLWKG---TRIEQLAYNSIMEIRQSDHKPVYAVFQVKVKTR----------DEVKYKRVQEE 494
            |||:|||.   |.|...:|....:|..|||.||:..|:|.|.::          .|..|  ::.|
Zfish   680 CDRILWKSYPETHIVCNSYGCTDDIVTSDHSPVFGTFEVGVTSQFVSKKGLPKSSEQAY--IEFE 742

  Fly   495 VLKAVDKRENDNQPQINVEKTVIDFGTVRFNEPSTRDFNVYNNCP-LPVDFSFKEKDIHAICEPW 558
            .::|:.|..:..:..|....|.::    .|.:....|....:|.. |.|.:|.|:.   ...:|.
Zfish   743 NIEAIVKTASRTKFFIEFYSTCLE----EFKKSYENDTQSSDNVNFLRVGWSSKQL---TTLKPI 800

  Fly   559 L-HVDPRQDSLLIDSARSIR---------LKMNANVRTIAGLLRKIRASDNFDILILHVENGRDI 613
            | .::..||..|:.:.:|:.         |.:.:.:.:.|         ..|...:.|  .|.:
Zfish   801 LSDIEYLQDQHLLLTVKSLDGYESYGECVLALKSMIGSTA---------QQFHTYLSH--RGEE- 853

  Fly   614 FITVTGDYQPSC-FGLSMETMCRTDRPLSEYSQDQIKQLMNDE--SPEYRVTMPREFFLLIDY-- 673
                ||:.:.|. ..:..|.|...:|.....|.|:      |:  .|:.|...||...   ||
Zfish   854 ----TGNIRGSMRVRVPSERMGTRERLYEWISVDK------DDMGGPKGRTLPPRSSH---DYVK 905

  Fly   674 -------LYRQGSKQVGAFPSYDSRLSLGAQFNSVRDWLDTWSD--------DPFPANAETAAQA 723
                   :.:.||.::       ||:|...:.:|......|..:        |||.::|.|...:
Zfish   906 PTSSSSSIRKHGSAEL-------SRVSEEGEKSSTSRHTHTKEENTHNRGKQDPFESDATTCKNS 963

  Fly   724 LLLLLDLPEHALLEPVVENLLECTNKSQAM 753
                .:.|.:.:||.|       .|:|.|:
Zfish   964 ----FNNPAYYILEGV-------PNQSAAL 982

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_569962.2	INPP5B_PH	23..160	CDD:465268	30/147 (20%)
		INPP5c_INPP5B	185..478	CDD:197327	102/325 (31%)
		RhoGAP_OCRL1	614..823	CDD:239845	34/160 (21%)
inppl1a	XP_073778854.1	None