DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and inppl1a

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001034893.1	Gene:	inppl1a / 325179	ZFINID:	ZDB-GENE-030131-3904	Length:	1266	Species:	Danio rerio

Alignment Length:	626	Identity:	159/626 - (25%)
Similarity:	250/626 - (39%)	Gaps:	178/626 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTLSEAVANGTATAATRTTKDIVKERFKE--DETIEYIFEAYQIKGPEYSN---RLLALVSSQS 60
            ::.||:.....:|:..:|    ::::...:  |:.:|::.....|.....|:   :.|..:...|
Zfish   214 LEILSKVFDQQSASMVSR----MIQQSMSQGGDQELEHLVTKLAILKDLLSSIEKKALKALQDMS 274

  Fly    61 GGTFAIIAFSYLRTPLSSANELIINKVFAIDHNFQLRQDSKSSITT-----QQFDLST-AEDGPI 119
            ..|.||       :||.|    |.|||..: ..|:::.|...:..|     |::.||. .|.|.:
Zfish   275 SSTPAI-------SPLLS----IRNKVIPV-QTFEVKLDVYLADLTKIGKSQKYSLSVDVEGGKL 327

  Fly   120 KYYYYATESHHYEEFVAKVISFKSTMAQHDPETVLNFRWLNDYRQ----------IGEV--KQEL 172
                              |:..|...||.|..|..:    :..||          :|.|  |::.
Zfish   328 ------------------VVMKKMKDAQEDWNTFTH----DKIRQLIKSQRVQNKLGIVFEKEKD 370

  Fly   173 KKRESEYI---------------VYKD----------IIIYCATWNVNNKTCSDSNNPLRAWL-- 210
            |.:..::|               :.|:          |.|:..|||:.:   ..:..||.:|:
Zfish   371 KSQRKDFIFASAKKREAFCQLLQLMKNKHSNQDEPDMISIFIGTWNMGS---VPAPKPLGSWILS 432

  Fly   211 -----ACSEK----PPDIYAIGLQELDTPTKAMLNSTQVQAIEKQWIDKMMDSV--HPDVEYEIL 264
                 ...|.    |.|||..|.||         ||    ..:|:|::.:..|:  :.|:||:.:
Zfish   433 RGLGKTLDEMAVTIPHDIYVFGTQE---------NS----VCDKEWVETLRCSLKEYTDMEYKPI 484

  Fly   265 MSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAH 329
            ....|....:.|:|:.:....|......||..||.|||||||.|.:|...|..:..|||.||.:.
Zfish   485 AVQTLWNIKIVVLVKAEHENRISHVGMSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSG 549

  Fly   330 MGYVEERNQDYNAIVEGIRFDDGRTISDHD------HIFWVGDLNYR----IQEPPGQQRPGPLS 384
            ...:..|||:|..|:..:...| :.::..|      |:||.||||||    |||...      ..
Zfish   550 NEKIHRRNQNYLDILRQLSLGD-KQLNSFDISLRFTHLFWFGDLNYRLDMDIQEILN------YI 607

  Fly   385 DAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRA-------PAY 442
            :.:.::.||:.|||..|..:.|.|..:.|.||.:.|||:|:.|:.:....:||:|       |::
Zfish   608 NRKEFDPLLKVDQLNLEREKNKIFLRFAEEEISYPPTYRYERGSRDTYVWQKQKATGMRTNVPSW 672

  Fly   443 CDRVLWKG---TRIEQLAYNSIMEIRQSDHKPVYAVFQVK------------------------- 479
            |||:|||.   |.|...:|....:|..|||.||:..|:|.
Zfish   673 CDRILWKSYPETHIVCNSYGCTDDIVTSDHSPVFGTFEVGVTSQFVSKKGLPKSSEQAYIEFENI 737

  Fly   480 ---VKTRDEVK-----YKRVQEEVLKAVDKRENDNQPQINV 512
               |||....|     |....||..|:.   |||.|...||
Zfish   738 EAIVKTASRTKFFIEFYSTCLEEFKKSY---ENDTQSSDNV 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	30/150 (20%)
		INPP5c_INPP5B	185..478	CDD:197327	102/325 (31%)
		RhoGAP_OCRL1	614..823	CDD:239845
inppl1a	NP_001034893.1	SH2_SHIP	15..113	CDD:198206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..159
		INPP5c_SHIP2-INPPL1	408..711	CDD:197335	102/325 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..951
		NPXY motif	958..961
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	986..1132
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1174
		SAM_Ship2	1204..1263	CDD:188890
		SAM	1207..1263	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910