Protein Alignment Ocrl and INPP5J

DIOPT Version :10

• Sequence 1: NP_569962.2
• Gene: Ocrl / 31157
• FlyBaseID: FBgn0023508
• Length: 850
• Species: Drosophila melanogaster
• Sequence 2: NP_001271214.1
• Gene: INPP5J / 27124
• HGNCID: 8956
• Length: 1006
• Species: Homo sapiens
• Alignment Length: 340
• Identity: 102/340 - (30%)
• Similarity: 156/340 - (45%)
• Gaps: 54/340 - (15%)

  Fly   187 IYCATWNVNNKTCSDS-NNPLRAWLACSEKPPDIYAIGLQELDTPTKAMLNSTQVQAI-EKQWID 249
            |...||||......|. .:.|...........|:.||||||::    :|||.....|: ..||.:
Human   425 ITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVN----SMLNKRLKDALFTDQWSE 485

  Fly   250 KMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQL 314
            ..||::.| ..:.::.|.|:...:|.:..:......:...:......|:....||||||::.|..
Human   486 LFMDALGP-FNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAA 549

  Fly   315 NEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFD--DGRTISDHDHIFWVGDLNYRIQEPPGQ 377
            ....:||:|.||.|||...|:|..::..|:...:|.  ..:.|.|||.:||.||||:||
Human   550 FGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFWFGDLNFRI------ 608

  Fly   378 QRPGPLSDAQTYEL--------------LLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGT 428
                     ::|:|              |.:.|||..........:|:.||.:.|.||:|:|.||
Human   609 ---------ESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGT 664

  Fly   429 DNYDSSEKQRAPAYCDRVLWK----------------GTRIEQLAYNSIMEIRQSDHKPVYAVFQ 477
            :.||:|.|:|.||:.||:|||                ..::.|.:|.|.||...||||||.|.|.
Human   665 NKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQFL 729

  Fly   478 VKVKTRDEVKYKRVQ 492
            ::...||::...|::
Human   730 LQFAFRDDMPLVRLE 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_569962.2	INPP5B_PH	23..160	CDD:465268
		INPP5c_INPP5B	185..478	CDD:197327	99/324 (31%)
		RhoGAP_OCRL1	614..823	CDD:239845
INPP5J	NP_001271214.1	PHA03247	<3..396	CDD:223021
		INPP5c_INPP5J-like	423..730	CDD:197328	99/324 (31%)
		SKICH	741..839	CDD:465482	1/4 (25%)