DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ocrl and INPP5J

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001271214.1	Gene:	INPP5J / 27124	HGNCID:	8956	Length:	1006	Species:	Homo sapiens

Alignment Length:	340	Identity:	102/340 - (30%)
Similarity:	156/340 - (45%)	Gaps:	54/340 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 IYCATWNVNNKTCSDS-NNPLRAWLACSEKPPDIYAIGLQELDTPTKAMLNSTQVQAI-EKQWID 249
            |...||||......|. .:.|...........|:.||||||::    :|||.....|: ..||.:
Human   425 ITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVN----SMLNKRLKDALFTDQWSE 485

  Fly   250 KMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQL 314
            ..||::.| ..:.::.|.|:...:|.:..:......:...:......|:....||||||::.|..
Human   486 LFMDALGP-FNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAA 549

  Fly   315 NEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFD--DGRTISDHDHIFWVGDLNYRIQEPPGQ 377
            ....:||:|.||.|||...|:|..::..|:...:|.  ..:.|.|||.:||.||||:||
Human   550 FGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFWFGDLNFRI------ 608

  Fly   378 QRPGPLSDAQTYEL--------------LLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGT 428
                     ::|:|              |.:.|||..........:|:.||.:.|.||:|:|.||
Human   609 ---------ESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGT 664

  Fly   429 DNYDSSEKQRAPAYCDRVLWK----------------GTRIEQLAYNSIMEIRQSDHKPVYAVFQ 477
            :.||:|.|:|.||:.||:|||                ..::.|.:|.|.||...||||||.|.|.
Human   665 NKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQFL 729

  Fly   478 VKVKTRDEVKYKRVQ 492
            ::...||::...|::
Human   730 LQFAFRDDMPLVRLE 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	99/324 (31%)
		RhoGAP_OCRL1	614..823	CDD:239845
INPP5J	NP_001271214.1	INPP5c_INPP5J-like	423..730	CDD:197328	99/324 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810