DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and syj2

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_595311.1	Gene:	syj2 / 2541098	PomBaseID:	SPBC577.13	Length:	889	Species:	Schizosaccharomyces pombe

Alignment Length:	481	Identity:	145/481 - (30%)
Similarity:	234/481 - (48%)	Gaps:	46/481 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 YQIKGPEYSNRLL---ALVSSQSGGTFAIIAFSYLRTPLSSANELI---INKVFAIDHNFQLRQD 99
            |||      :||:   ...:.|.|.||.|:  .|||...|:..:.|   |..|.:|..:...|
pombe   441 YQI------SRLVLKDIFFNLQIGVTFNIL--EYLRHLWSNNGDAIAKLITGVGSIGSSATRR-- 495

  Fly   100 SKSSITTQQFDLSTAEDGPIKYYYYATESHHYEEFVAKVISFKSTMAQHDPETVLNFRWLNDYRQ 164
            .:.||.....|:|.:........|...||.:      .::..........|  ||....::.|
pombe   496 GRKSIAGSLSDISKSFGRMYVGRYPDVESQN------AILLLLGCFPNQSP--VLISESVSSY-- 550

  Fly   165 IGEVKQELKKRESEYIVYKDIIIYCATWNVNNKTCSDSNNPLRAWLACSEKPP--DIYAIGLQEL 227
               ::..|::|.|||.|.:|..|:.:|:|.|.|..| ::...|..|...|:..  |:|.:.:||:
pombe   551 ---IQGVLRQRRSEYRVERDFSIFSSTFNANGKVPS-TDEFKRLLLPFGERTSAYDLYVVAVQEI 611

  Fly   228 DTPTKAMLNSTQVQAIEKQWIDK---MMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRC 289
            .|...:.|.|:..|.: :.|.:|   :::|...:.:|.::.|.::....|.|.:||.  .|::..
pombe   612 ITLNMSHLVSSSNQKL-RIWEEKILMILNSRDSNNKYMLISSIQMAGVFLGVFIRKD--DHLVVS 673

  Fly   290 RPKSVAR--GIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDG 352
            :.....|  |......|||.|||.:.:.:.:.|||:||.|..:..:.|||.:|.:|.:.:.|..|
pombe   674 KVTKTTRKTGFGGFSANKGAVAIEMNVCDSDFCFVSSHFAPKVNNISERNMEYTSISDNLVFPSG 738

  Fly   353 RTISDHDHIFWVGDLNYRIQEPPGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIK 417
            ..|.||.:|.|:||.||||.....:.|  .|.:....:.|..||||..||::|..|.|..|.::.
pombe   739 MKIYDHTNILWMGDFNYRIDSDNEEVR--KLVELDDLDKLASYDQLCTEMKKGTVFHGLVEPQLT 801

  Fly   418 FRPTYKYDPGTDNYDSSEKQRAPAYCDRVLWKGTR-IEQLAYNSIMEIRQSDHKPVYAVFQVKVK 481
            |.||||:|.||::||:|:|||.|::.||:|  .|: ..:..|.| .:||.|||:||:|.|.:|:.
pombe   802 FLPTYKFDNGTNDYDTSDKQRVPSWTDRIL--ATKSFTRNCYKS-CDIRCSDHRPVFATFSLKIF 863

  Fly   482 TRDEVKYKRVQEEVLKAVDKRENDNQ 507
            :....|...:..:...|..|.:|.|:
pombe   864 STCMDKKAGIIRDARIAYIKSKNSNK 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	29/127 (23%)
		INPP5c_INPP5B	185..478	CDD:197327	102/300 (34%)
		RhoGAP_OCRL1	614..823	CDD:239845
syj2	NP_595311.1	COG5329	1..552	CDD:227637	30/133 (23%)
		Syja_N	62..370	CDD:280532
		COG5411	539..>889	CDD:227698	118/365 (32%)
		EEP	569..858	CDD:294334	101/297 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3488
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840