DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ocrl and Inpp5k

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	XP_006532570.1	Gene:	Inpp5k / 19062	MGIID:	1194899	Length:	472	Species:	Mus musculus

Alignment Length:	352	Identity:	106/352 - (30%)
Similarity:	162/352 - (46%)	Gaps:	55/352 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 IYCATWNVNNKT----CSD----SNNPLRAWLACSEKPPDIYAIGLQELDTPTKAMLNSTQVQAI 243
            ::..||||.:..    .||    :|..|..         |||.|||||::....::|:..   |.
Mouse    34 VHVVTWNVASAAPTVDLSDLLQLNNQDLNL---------DIYIIGLQEMNFGIISLLSDA---AF 86

  Fly   244 EKQWIDKMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGV 308
            |..|....||.:.| :.:..:...|:...:|.|..:.|...:|.....||...|::...||||||
Mouse    87 EDPWSSLFMDMLSP-LNFVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSTPTGLYGYWGNKGGV 150

  Fly   309 AISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFD--DGRTISDHDHIFWVGDLNYRI 371
            .:.|:|....:..:|.||..||...::|.:.::.|:|.:.|:  |...|.|||.|.|.||:|:||
Mouse   151 NVCLKLYGYYVSIINCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRI 215

  Fly   372 QEPPGQQRPGPLSDAQT-----YELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNY 431
            ::      .|.|...::     |:.|.:.|||....:..:....:.||.:.|.||||:|..::||
Mouse   216 ED------FGLLFVQESITRKYYKELWEKDQLFIAKKNDQLLREFQEGPLLFPPTYKFDRHSNNY 274

  Fly   432 DSSEKQRAPAYCDRVLWKGTRIEQLA------------------YNSIMEIRQSDHKPVYAVFQV 478
            |:|||:|.||:.||:||:..|....|                  |.|.|....||||||...|.:
Mouse   275 DTSEKKRKPAWTDRILWRLKRQPSQASPLASSVPTSYFLLTLKNYVSHMAYSISDHKPVTGTFDL 339

  Fly   479 KVKTRDEVKYKRVQEEVLKAVDKREND 505
            ::.....|....:..|.|..:   |||
Mouse   340 ELNPLMSVPLITMMPEHLWTM---END 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	100/323 (31%)
		RhoGAP_OCRL1	614..823	CDD:239845
Inpp5k	XP_006532570.1	EEP	32..339	CDD:382041	100/323 (31%)
Inpp5k	XP_006532570.1	SKICH	350..454	CDD:375315	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810