DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ocrl and cil-1

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_498783.1	Gene:	cil-1 / 183643	WormBaseID:	WBGene00086546	Length:	398	Species:	Caenorhabditis elegans

Alignment Length:	327	Identity:	86/327 - (26%)
Similarity:	147/327 - (44%)	Gaps:	59/327 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 TWNVNNKTCSDS---NNPLRAWLACSEKPPDIYAIGLQEL---DTPTKAMLN-STQVQAIEKQWI 248
            |:|:..| .|||   :|.|...:   :....:.||||||:   :|...|:|. :|.:.:    |:
Worm     9 TYNLAMK-ASDSEAVHNMLNGMI---DDHTHLVAIGLQEVAHSETIGGAVLTWATTIAS----WM 65

  Fly   249 D---KMMDSVHPDVEYEILMSHRLVAT-MLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVA 309
            :   :|           :|::....|| .:.:..||||...|.|...:.....:....|:||.:.
Worm    66 NTNGRM-----------VLLAKTFQATNQVLIFGRKQLIGQIKRIDYRFQRNTMGGLTGHKGSIG 119

  Fly   310 ISLQL-NEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRTISDHDHIFWVGDLNYRIQE 373
            :.||| :..:|.||:||.........:|.:.|:. .....|.:.:::.   ..||.||.|:|::|
Worm   120 VRLQLASPYSIVFVDSHFIHGPENYGKRVEQYHT-NRNCSFPEDKSVR---AAFWFGDFNFRVEE 180

  Fly   374 PPGQQRPGPLSDAQT----------YELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGT 428
                       |..|          .|||...:||::.:.....|.|:.|..:.|.|||:...||
Worm   181 -----------DVNTVIRKIKNGTHLELLDTREQLKRALVERDAFIGFHEQPVTFEPTYRVTVGT 234

  Fly   429 DNYDSSEKQRAPAYCDRVLWKGTRIEQLAYNSIMEIRQSDHKPVYAVFQVKVKTRDEVKYKRVQE 493
            ...|.   :|.|::.||:|:||..|..|:|.:..:...|||.||.|:|:|......:.:::.:.|
Worm   235 TEQDG---KRVPSWTDRILYKGDGITGLSYTNNKKAVASDHLPVVAMFRVTAPAAPKPQWEVIFE 296

  Fly   494 EV 495
            .:
Worm   297 HL 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	84/308 (27%)
		RhoGAP_OCRL1	614..823	CDD:239845
cil-1	NP_498783.1	IPPc	1..284	CDD:214525	85/311 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810