DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ocrl and unc-26

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001023266.1	Gene:	unc-26 / 178284	WormBaseID:	WBGene00006763	Length:	1119	Species:	Caenorhabditis elegans

Alignment Length:	446	Identity:	136/446 - (30%)
Similarity:	215/446 - (48%)	Gaps:	65/446 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 AIDHNFQLRQDSKSSITTQQFDLSTAEDGPIKYYYYATESHHYEEFVAKVISFK--STMAQHDPE 151
            |:|...:|:..|:|...|.|.:|.   ||                  ||..||.  .|.|.:||.
Worm   441 ALDGKSKLKDASRSLARTIQNNLM---DG------------------AKQESFDLFLTGAAYDPR 484

  Fly   152 ------TVLNFRWLND---YRQIGEVKQELKKRESEYIVYKDIIIYCATWNVN-----NKTCSDS 202
                  .:|....:.:   |.:..:...:|.:|..|....:.|.|:..|||||     :.....:
Worm   485 LFDRACNILPPSLIQESYYYHEYADAVSQLVERSPEIAEPQSIKIFVGTWNVNGGKNIHNVAFRN 549

  Fly   203 NNPLRAWLACS----------EKPPDIYAIGLQEL-DTPTKAMLNSTQVQAIEKQWIDKMMDSVH 256
            .:.|..|:..:          |:..||.|||::|| |.....|:.::...  ::.|.:.:..::.
Worm   550 ESSLSHWIFANSMTRLVSVEDEQLADIVAIGVEELVDLNASNMVKASTTN--QRMWCESIRKTLS 612

  Fly   257 PDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQLNEGNICF 321
            ....:.::.|.:||...|.:..|.::..::......||..|:....||||.||..:.:...:|||
Worm   613 EKAPFVLIGSEQLVGVCLFLFARPRVSPYLKDFAVASVKTGMGGATGNKGSVAFRIVVFSTSICF 677

  Fly   322 VNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRTISDHDHIFWVGDLNYRI----QEPPGQQRPGP 382
            :.||.||....:.:||:|:...::.|||..||.|..||.|||:||.||||    .|.....|.|
Worm   678 ICSHFAAGQNEIRDRNEDFATTLKKIRFPLGREIDSHDVIFWLGDFNYRINLSGDEVKNAVRNG- 741

  Fly   383 LSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRVL 447
                 .|..|::.|||.|:...|:.|.|:.||::.|.||||||..:|:||:|||.||||:.||:|
Worm   742 -----DYAKLVENDQLTQQKALGQTFVGFNEGQLTFAPTYKYDTFSDDYDTSEKCRAPAWTDRIL 801

  Fly   448 WKGTR----IEQLAYNSIMEIRQSDHKPVYAVFQVKVKTRDEVKYKRVQEEVLKAV 499
            ||..|    .:.|:|:. .|::.|||:||.|||:|:.......|...:.|:|::::
Worm   802 WKDQRKKGKTQLLSYDR-SELKTSDHRPVGAVFKVETFKVGGRKCVELIEDVVESM 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	19/84 (23%)
		INPP5c_INPP5B	185..478	CDD:197327	109/316 (34%)
		RhoGAP_OCRL1	614..823	CDD:239845
unc-26	NP_001023266.1	Syja_N	60..336	CDD:280532
		INPP5c_Synj	527..835	CDD:197323	109/316 (34%)
		RRM_SF	850..978	CDD:302621	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910