DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and ocrl-1

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001361846.1	Gene:	ocrl-1 / 172822	WormBaseID:	WBGene00007620	Length:	712	Species:	Caenorhabditis elegans

Alignment Length:	702	Identity:	226/702 - (32%)
Similarity:	351/702 - (50%)	Gaps:	109/702 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 EVKQELKKRESEYIVYKDIIIYCATWNVNNKTCSDSNNPLR---AWLACSEKPPDI---YAIGLQ 225
            :|.:.:::...::..::|:.|..:|:|||.:      :||.   .|.  |:||.||   ||:|||
Worm    21 KVDEVMREWMHKFCTFQDVKICVSTFNVNGR------SPLSVFPTWF--SQKPEDIAEFYAVGLQ 77

  Fly   226 ELD--TPTKAMLNSTQVQAIEKQWIDKMMDSVHPDV-----EYEILMSHRLVATMLTVIVRKQLR 283
            |:|  ..|..:.|:.:::.    |:    |::|..:     ::.::.|.|||...:.|......:
Worm    78 EMDLSVGTYIIDNTKKMEG----WV----DAIHCSLPGGRTQFNVVGSMRLVGIFVIVFQAVNSK 134

  Fly   284 QHIIRCRPKSVARGI---FNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQD----YN 341
            ..:.....|.||.||   .|.||||||.|:|:::|:..:||||:|.||....:|.||||    ||
Worm   135 VRVSDVNVKYVATGISVLVNKLGNKGGTAVSMKMNDTWVCFVNAHFAAGNNELERRNQDFRDIYN 199

  Fly   342 AIV-------EGIRFDDGRTIS-------DHDHIFWVGDLNYRIQEPP---GQQRPGPLSDAQTY 389
            .:|       ||:|   .|.:.       |||.:||.||||||:....   .......::.:..:
Worm   200 DMVFYPRSQQEGLR---DRPLEVPIMCLYDHDVVFWFGDLNYRLNTDMYGISNDEVRRIASSDKF 261

  Fly   390 ELLLQYDQLRQEMRRGKCFEGYTE-GEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRVL-WKGTR 452
            ..|||:.|||::|.||..|:.:.| ..:.||||||||.||:.:|:|||.|.||:.||:| :|  :
Worm   262 ADLLQHCQLREQMARGTVFKDFEEPSTLPFRPTYKYDCGTNTWDTSEKGRVPAWTDRILTFK--K 324

  Fly   453 IEQLAYNSIM------EIRQSDHKPVYAVFQVKVKTRDEVKYKRVQEEVLKAVDKRENDNQPQIN 511
            ..|:...||.      .|..||||||.|:|.:|||..:|.....|.||.::..|:|.|:..||:.
Worm   325 YPQVGLESIRPMVSIDTITISDHKPVRAMFNLKVKKINESGANNVYEEAIREADRRANEELPQVQ 389

  Fly   512 VEKTVIDFGTVRFNEPSTRDFNVYNNCPLPVDFSFK----EKDIHAICEPWLHVDPRQDSLLIDS 572
            :....:|||.|.:.||.||...|.|.....|.||||    .::...|||.||.|.|....:...|
Worm   390 LSLNEVDFGIVNYLEPKTRSVIVQNVGKSKVRFSFKVRPNARNNQEICEKWLMVTPTHYQIPQGS 454

  Fly   573 ARSIRLKMNAN---VRTIAGLLRKIRASDNFDILILHVENGRDIFITVTGDYQPSCFGLSMETMC 634
            :..|.|.::.:   ||.|..|:|..:..   :||:||:|||||.||.:|..|..||||.::|.:.
Worm   455 SMEISLTVSISTDIVRRIQDLIRNGQLQ---EILVLHLENGRDYFIPITAVYNNSCFGSTLEKLL 516

  Fly   635 RTDRPLSEYS----QDQIKQLMNDESPEYRVTMPREFFLLIDYLYRQGSKQVGAFPSYDSRLSLG 695
             :.||..|.:    .|..:..::|..|.   .:||..:.|:..|..:|:.|:......|:.:
Worm   517 -SMRPKKEVNLIDFGDFSENSLSDNCPP---NVPRVIYRLVMALRTRGAVQLNIEEEQDNEV--- 574

  Fly   696 AQFNSVRDWLDTWSDDPFP--ANAETAAQALLLLLDLPEHALLEPVV-ENLLECTNKSQAMDY-- 755
              ||.:|..|::...|...  |::.....||:.|||    :|.||:: |.:.:..:| :.:.|
Worm   575 --FNRIRSALESGQPDDLSQLASSYMLYSALIRLLD----SLDEPIILEGMFKIIHK-EMIKYRT 632

  Fly   756 -------ISLLSPPKRN--VFMHLCMFLRAGIESQFYDLHQVASTFGRILLR 798
                   :...|.||:|  |...:|:.||. ..||.|:|....|.:..:|.|
Worm   633 DARQLWTVVRSSLPKQNQAVLELICLMLRE-FFSQKYELKDQLSLWATVLFR 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	119/337 (35%)
		RhoGAP_OCRL1	614..823	CDD:239845	54/203 (27%)
ocrl-1	NP_001361846.1	INPP5c	39..356	CDD:197308	119/337 (35%)
ocrl-1	NP_001361846.1	RhoGAP_OCRL1	496..705	CDD:239845	54/203 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156637
Domainoid	1	1.000	129	1.000	Domainoid score	I3269
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I1795
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54104
OrthoDB	1	1.010	-	-		D129921at33208
OrthoFinder	1	1.000	-	-		FOG0002633
OrthoInspector	1	1.000	-	-		oto19561
orthoMCL	1	0.900	-	-		OOG6_101357
Panther	1	1.100	-	-	LDO	PTHR11200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3488
SonicParanoid	1	1.000	-	-		X494
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.940