DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and Inpp5d

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	XP_006529212.1	Gene:	Inpp5d / 16331	MGIID:	107357	Length:	1196	Species:	Mus musculus

Alignment Length:	560	Identity:	142/560 - (25%)
Similarity:	241/560 - (43%)	Gaps:	136/560 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ETIEYIFEAYQIKG----PEYSNRLLALVSSQSGGTFAIIAFSYLRTPLSSANELIINKVFAIDH 92
            |:::.:|:.....|    |:        |..::.....:...|.|.:.|||    |.:||.::.|
Mouse   235 ESLQRLFDQQLSPGLRPRPQ--------VPGEASPITMVAKLSQLTSLLSS----IEDKVKSLLH 287

  Fly    93 ---------------NFQLRQDS---------KSSITTQQFDLSTAEDGPIKYYYYATESH---- 129
                           .|:::.:|         |..:.:.:..:..::||....:|    ||
Mouse   288 EGSESTNRRSLIPPVTFEVKSESLGIPQKMHLKVDVESGKLIVKKSKDGSEDKFY----SHKKIL 348

  Fly   130 ---HYEEFVAKVISFKSTMAQHDPETVL--NFRWLNDYRQIG--EVKQELKKRESEYIVYKDIII 187
               ..::|:.|::    .:.:.:.|.:|  .:.:.:..::.|  ::.|::|.:.||......|.|
Mouse   349 QLIKSQKFLNKLV----ILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITI 409

  Fly   188 YCATWNVNN-----------------KTCSDSNNPLRAWLACSEKPPDIYAIGLQELDTPTKAML 235
            :..|||:.|                 ||..||.:.:         |.|||.||.||  .|..
Mouse   410 FIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYI---------PHDIYVIGTQE--DPLG--- 460

  Fly   236 NSTQVQAIEKQWIDKMMDSVH--PDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGI 298
                    ||:|::.:..|:.  ..:.::.:..|.|....:.|:.:.:....|......:|..||
Mouse   461 --------EKEWLELLRHSLQEVTSMTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGI 517

  Fly   299 FNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRTISDHD---- 359
            .|||||||.|.:|...|..::.||||||.:.......|||:|..|:..:...| :.:|..:
Mouse   518 ANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGD-KKLSPFNITHR 581

  Fly   360 --HIFWVGDLNYRIQEPPGQQRPGPLSDA-------QTYELLLQYDQLRQEMRRGKCFEGYTEGE 415
              |:||:||||||::.|..:      ::|       |.|..||.:|||..|.:..|.|..:.|.|
Mouse   582 FTHLFWLGDLNYRVELPTWE------AEAIIQKIKQQQYSDLLAHDQLLLERKDQKVFLHFEEEE 640

  Fly   416 IKFRPTYKYDPGTDNYDSSEKQRA-------PAYCDRVLWKGTRIEQL---AYNSIMEIRQSDHK 470
            |.|.|||:::..|.:..:..||:|       |::|||||||...:..:   :|.|..:|..|||.
Mouse   641 ITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHS 705

  Fly   471 PVYAVFQVKVKTRDEVKYKRVQEEVLKAVDKRENDNQPQI 510
            ||:|.|:..|.:      :.|.:.|..|......|:|.||
Mouse   706 PVFATFEAGVTS------QFVSKNVSHAPGPGTVDSQGQI 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	26/167 (16%)
		INPP5c_INPP5B	185..478	CDD:197327	103/334 (31%)
		RhoGAP_OCRL1	614..823	CDD:239845
Inpp5d	XP_006529212.1	SH2_SHIP	4..105	CDD:198206
Inpp5d	XP_006529212.1	INPP5c_SHIP1-INPP5D	407..713	CDD:197334	103/334 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810