Protein Alignment Ocrl and Inpp5d

DIOPT Version :10

• Sequence 1: NP_569962.2
• Gene: Ocrl / 31157
• FlyBaseID: FBgn0023508
• Length: 850
• Species: Drosophila melanogaster
• Sequence 2: XP_006529212.1
• Gene: Inpp5d / 16331
• MGIID: 107357
• Length: 1196
• Species: Mus musculus
• Alignment Length: 560
• Identity: 142/560 - (25%)
• Similarity: 241/560 - (43%)
• Gaps: 136/560 - (24%)

  Fly    32 ETIEYIFEAYQIKG----PEYSNRLLALVSSQSGGTFAIIAFSYLRTPLSSANELIINKVFAIDH 92
            |:::.:|:.....|    |:        |..::.....:...|.|.:.|||    |.:||.::.|
Mouse   235 ESLQRLFDQQLSPGLRPRPQ--------VPGEASPITMVAKLSQLTSLLSS----IEDKVKSLLH 287

  Fly    93 ---------------NFQLRQDS---------KSSITTQQFDLSTAEDGPIKYYYYATESH---- 129
                           .|:::.:|         |..:.:.:..:..::||....:|    ||
Mouse   288 EGSESTNRRSLIPPVTFEVKSESLGIPQKMHLKVDVESGKLIVKKSKDGSEDKFY----SHKKIL 348

  Fly   130 ---HYEEFVAKVISFKSTMAQHDPETVL--NFRWLNDYRQIG--EVKQELKKRESEYIVYKDIII 187
               ..::|:.|::    .:.:.:.|.:|  .:.:.:..::.|  ::.|::|.:.||......|.|
Mouse   349 QLIKSQKFLNKLV----ILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITI 409

  Fly   188 YCATWNVNN-----------------KTCSDSNNPLRAWLACSEKPPDIYAIGLQELDTPTKAML 235
            :..|||:.|                 ||..||.:.:         |.|||.||.||  .|..
Mouse   410 FIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYI---------PHDIYVIGTQE--DPLG--- 460

  Fly   236 NSTQVQAIEKQWIDKMMDSVH--PDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGI 298
                    ||:|::.:..|:.  ..:.::.:..|.|....:.|:.:.:....|......:|..||
Mouse   461 --------EKEWLELLRHSLQEVTSMTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGI 517

  Fly   299 FNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRTISDHD---- 359
            .|||||||.|.:|...|..::.||||||.:.......|||:|..|:..:...| :.:|..:
Mouse   518 ANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGD-KKLSPFNITHR 581

  Fly   360 --HIFWVGDLNYRIQEPPGQQRPGPLSDA-------QTYELLLQYDQLRQEMRRGKCFEGYTEGE 415
              |:||:||||||::.|..:      ::|       |.|..||.:|||..|.:..|.|..:.|.|
Mouse   582 FTHLFWLGDLNYRVELPTWE------AEAIIQKIKQQQYSDLLAHDQLLLERKDQKVFLHFEEEE 640

  Fly   416 IKFRPTYKYDPGTDNYDSSEKQRA-------PAYCDRVLWKGTRIEQL---AYNSIMEIRQSDHK 470
            |.|.|||:::..|.:..:..||:|       |::|||||||...:..:   :|.|..:|..|||.
Mouse   641 ITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHS 705

  Fly   471 PVYAVFQVKVKTRDEVKYKRVQEEVLKAVDKRENDNQPQI 510
            ||:|.|:..|.:      :.|.:.|..|......|:|.||
Mouse   706 PVFATFEAGVTS------QFVSKNVSHAPGPGTVDSQGQI 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_569962.2	INPP5B_PH	23..160	CDD:465268	26/164 (16%)
		INPP5c_INPP5B	185..478	CDD:197327	103/334 (31%)
		RhoGAP_OCRL1	614..823	CDD:239845
Inpp5d	XP_006529212.1	SH2_SHIP	4..105	CDD:198206
		INPP5c_SHIP1-INPP5D	407..713	CDD:197334	103/334 (31%)