DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ocrl and Synj1

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	XP_011244377.1	Gene:	Synj1 / 104015	MGIID:	1354961	Length:	1714	Species:	Mus musculus

Alignment Length:	369	Identity:	117/369 - (31%)
Similarity:	178/369 - (48%)	Gaps:	64/369 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 EYIVYKDIIIYCATWNVNN----KTCSDSNNPLRAWLACS-------------EKPPDIYAIGLQ 225
            :|...|.|.:...|||||.    ::.:..|..|..||..:             .||.||:|||.:
Mouse   673 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFE 737

  Fly   226 EL-DTPTKAMLNSTQVQAIEKQWIDKMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRC 289
            |: :.....::|::...  :|.|..::..::..|.:|.:|.|.:||...|.|.:|.|....|...
Mouse   738 EMVELNAGNIVNASTTN--QKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDV 800

  Fly   290 RPKSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRT 354
            ...:|..|:....||||.|||.:..:..::|||.||.||....|:|||:|:..|...:.|..||.
Mouse   801 AVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFVEIARKLSFPMGRM 865

  Fly   355 ISDHDHIFWVGDLNYRIQEPPGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFR 419
            :..||::||.||.||||..|  .:....|...|.::.|:..|||..:...|:.|.|:.||::.|.
Mouse   866 LFSHDYVFWCGDFNYRIDLP--NEEVKELIRQQNWDSLIAGDQLINQKNAGQIFRGFLEGKVTFA 928

  Fly   420 PTYKYDPGTDNYDSSEKQRAPAYCDRVLWK--------------------------------GTR 452
            ||||||..:::||:|||.|.||:.|||||:                                ||
Mouse   929 PTYKYDLFSEDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGT- 992

  Fly   453 IEQLAYNSIMEIRQSDHKPVYA-----VFQVKVKTRDEVKYKRV 491
               |.:....|::.|||:||.|     :|:|:.:.|.:: ||.|
Mouse   993 ---LLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQKI-YKEV 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	110/347 (32%)
		RhoGAP_OCRL1	614..823	CDD:239845
Synj1	XP_011244377.1	COG5329	204..627	CDD:227637
		INPP5c_Synj1	680..1015	CDD:197332	109/342 (32%)
		RRM_SF	1014..1155	CDD:388407	6/20 (30%)
		PHA03247	<1207..1609	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810