DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and ocrl

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	XP_004919252.2	Gene:	ocrl / 100125214	XenbaseID:	XB-GENE-991489	Length:	909	Species:	Xenopus tropicalis

Alignment Length:	701	Identity:	235/701 - (33%)
Similarity:	368/701 - (52%)	Gaps:	71/701 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 GEVKQELKKRESEYIVYKDIIIYCATWNVNNKTCSDSNNPLRAWLACSEKPPDIYAIGLQELDTP 230
            |.:|..|.|:|::|:..|:...:..|||||.::   .:..|..||....:|||:|.||.||||..
Frog   228 GLIKHILAKKENDYVNIKNFRFFVGTWNVNGQS---PDGGLEPWLQADAEPPDVYVIGFQELDLS 289

  Fly   231 TKAMLNSTQVQAIEKQWIDKMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVA 295
            |:|.......:  |::|::.:...:|...:|:.:...|||..|:.|..:.:..:||.....:||.
Frog   290 TEAFFYFDSGK--EQEWLEAVERCLHTKAKYKNVRLIRLVGMMMLVFAKHEHFKHIREVVAESVG 352

  Fly   296 RGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRF---DDGRTISD 357
            .||...:|||||||:....:..:.||||||||||:...|.|||||..|...:.|   |....||:
Frog   353 TGIMGKMGNKGGVAVRFVFHNTSFCFVNSHLAAHVEDFERRNQDYKDICARLNFTVPDQNIPISN 417

  Fly   358 ---HDHIFWVGDLNYRIQEPPGQQRPGPL--SDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIK 417
               ||.:.|:||||||:.:....:....:  :|.||   ||:||||..:......|..:|||.|.
Frog   418 IMKHDVVIWLGDLNYRLCKFDAAEVKSLIAKNDIQT---LLKYDQLNIQREMKNVFSDFTEGTIN 479

  Fly   418 FRPTYKYDPGTDNYDSSEKQRAPAYCDRVLWKGTRIEQLAYNSIMEIRQSDHKPVYAVFQVKVKT 482
            |.||||:|..||.:|||.|.|.||:||||||:||.|.||.|.|.||::.||||||.::|.:.||.
Frog   480 FIPTYKFDAKTDRWDSSGKCRVPAWCDRVLWRGTNITQLKYRSHMELKTSDHKPVSSLFSIGVKV 544

  Fly   483 RDEVKYKRVQEEVLKAVDKRENDNQPQINVEKTVIDFGTVRFNEPSTRDFNVYNNCPLPVDFSF- 546
            .||.:|::..|::::.:|:.||:..|.:|:.:....|..|||.:.....|.:.|:..:...|||
Frog   545 VDERRYRKAFEDIVRMMDRMENEFLPSLNLSRREFVFERVRFRQLQKEKFQIKNDGQVTCHFSFI 609

  Fly   547 -KEKDIHAICEPWLHVDPRQDSLLIDSARSIRLKMNANVRTIAGLLR---KIRASDNFDILILHV 607
             |..|.. .|:|||..:|.:..|..:....|.|::..:..::..|..   ||.     |||:||:
Frog   610 PKLNDTQ-YCKPWLRAEPCEGYLEPEETVDISLEVYVSKDSVTMLNSEEDKIE-----DILVLHL 668

  Fly   608 ENGRDIFITVTGDYQPSCFGLSMETMCRTDRPLSE-------------YSQD-----QIKQLMND 654
            :.|:|.|:|::|.|..||||.|:|.:||..||:.|             :|:.     |:..|.:|
Frog   669 DRGKDYFLTISGSYLVSCFGTSLEALCRMKRPIREIPVTKLIDLGEDSFSEKEKAALQMLPLESD 733

  Fly   655 ESPEYRVTMPREFFLLIDYLYRQGSKQVGAFPSYDSRLSLGAQFNSVRDWLDTWSDDPFPANAET 719
            |:.:..:.:|:|.:||:|:||:...:|...|.:...:    .:...:.|.|||...:..|.:..:
Frog   734 ETADKPMKIPKEIWLLVDHLYKNACRQEDLFQTPGKQ----EELQQIIDCLDTSIPETIPGSNHS 794

  Fly   720 AAQALLLLLD-LPEHALLEPVVENLLECTNKSQ-AMDYISLLSPPKRNVFMHLCMFLRAGIE--- 779
            .|:|||:.|: |||..:...:.:..::|::.:: ....||.|....||||.:|..|||..::
Frog   795 VAEALLIFLEALPEPVICYELYQRCIDCSHDTRLCRQVISQLPRCHRNVFRYLMAFLRELLKYTG 859

  Fly   780 SQFYDLHQVASTFGRILLR----------STERAAWMDYHSRCIQFMRLFI 820
            ......:.:|:.|..:|||          .:||       .|.|.|:..|:
Frog   860 DNNLSANMIATVFTSLLLRPPPNLIGKQTPSER-------QRAINFILGFL 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	123/300 (41%)
		RhoGAP_OCRL1	614..823	CDD:239845	65/240 (27%)
ocrl	XP_004919252.2	OCRL_clath_bd	15..116	CDD:406996
		INPP5c_INPP5B	247..540	CDD:197327	123/300 (41%)
		RhoGAP_OCRL1	675..906	CDD:239845	65/240 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H233
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129921at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010