Protein Alignment eIF2Bepsilon and EIF2B3

DIOPT Version :9

• Sequence 1: NP_569961.2
• Gene: eIF2Bepsilon / 31156
• FlyBaseID: FBgn0023512
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: XP_016858234.1
• Gene: EIF2B3 / 8891
• HGNCID: 3259
• Length: 457
• Species: Homo sapiens
• Alignment Length: 421
• Identity: 89/421 - (21%)
• Similarity: 150/421 - (35%)
• Gaps: 89/421 - (21%)

  Fly    10 QAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIREHIRA 74
            |||::|.........|:......|||:.|..::.|.|..|.|.|.|||.|.|:       ..::.
Human     4 QAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTT-------RDVQK 61

  Fly    75 GIATDAAWSFKMTVHVIGGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRPVLE----- 134
            .:..:.....|..:..|..:......|::|.:..|  ::...::|..|.:|:..|..|::
Human    62 ALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPK--LKTDVLVLSCDLITDVALHEVVDLFRAY 124

  Fly   135 -------QHKRQAKFD-----KG---------------TAATLVFKECANNVRTGNEVLIAVDRR 172
                   ..|.|...:     ||               |...|:|  .||......|::|    :
Human   125 DASLAMLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLF--MANEADLDEELVI----K 183

  Fly   173 NDRLHYHQRLRMH------HKENRYQLPLDVFLGNSCVALHHNLLDPQIAIGSPSMLSLFNDNFD 231
            ...|..|.|:|.|      |.....:..:|..:.|..:....:.|.|.:.  .....|..:....
Human   184 GSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLV--RKQFSSASSQQGQ 246

  Fly   232 FQTRDDFVRGLLINEELLDSRIY----------VALLPAAQYAHKVNNWPAYQLVSRDIINRWAY 286
            .:..:|     |..:||....||          :|...|...|.:.:.|   :.:||..:..:.:
Human   247 EEKEED-----LKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRW---EDLSRSQVRCYVH 303

  Fly   287 PF-------VPDIGLY--------KLQQEYVFHKDNIYKSPEAHVSKVALLQNVVIEAGSHVDSG 336
            ..       |..:|||        ||.......:..::.|.:. |||..:..:.:|...:.:...
Human   304 IMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQI-VSKHLVGVDSLIGPETQIGEK 367

  Fly   337 SVISDSVIGANCRIGKNCRLTNAFLMADVTV 367
            |.|..||||::|.|.....:||..||..|||
Human   368 SSIKRSVIGSSCLIKDRVTITNCLLMNSVTV 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	50/250 (20%)
		GCD1	22..409	CDD:224129	85/409 (21%)
		LbetaH	326..397	CDD:294107	16/42 (38%)
		W2_eIF2B_epsilon	499..659	CDD:211396
EIF2B3	XP_016858234.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810