DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF2Bepsilon and GCD1

DIOPT Version :9

Sequence 1:	NP_569961.2	Gene:	eIF2Bepsilon / 31156	FlyBaseID:	FBgn0023512	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_014903.1	Gene:	GCD1 / 854434	SGDID:	S000005786	Length:	578	Species:	Saccharomyces cerevisiae

Alignment Length:	563	Identity:	118/563 - (20%)
Similarity:	202/563 - (35%)	Gaps:	158/563 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EIVQAVLIADNNVWN-FKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEV------------- 57
            |:|.:.|  |:.|.| |...|.....||||:.|..|::|.|...:::..:|:
Yeast    43 ELVNSAL--DSTVINEFMQHSTRLPKALLPIGNRPMIEYVLDWCDQADFKEISVVAPVDEIELIE 105

  Fly    58 ---------------FVYTSLYRSSIREHIRAGIATDAAWSFKMTVHVIGGEGCRCFGDAMRDLD 107
                           .:|.:|..|:...|::.          ...::.|..: ....|::::
Yeast   106 SGLTSFLSLRKQQFELIYKALSNSNHSHHLQD----------PKKINFIPSK-ANSTGESLQ--- 156

  Fly   108 NKAL---IRGHFILLGADTVTNADLRPVLEQHKRQAKFDKGTAATLVFKECANNVRTGNEVLIAV 169
             |.|   |.|.|::|..|.||:...:.:::|.:.  :.|...|.|:.:|         |.:..::
Yeast   157 -KELLPRINGDFVILPCDFVTDIPPQVLVDQFRN--RDDNNLAMTIYYK---------NSLDSSI 209

  Fly   170 DRRNDRLHYHQRLRMHHKEN----RYQLPLDVF-----------------------------LGN 201
            |::..:....|:....:.||    |..:.|||:                             |.|
Yeast   210 DKKQQQKQKQQQFFTVYSENEDSERQPILLDVYSQRDVTKTKYLQIRSHLLWNYPNLTVSTKLLN 274

  Fly   202 S---------CVALHHNLLDPQIAIGSPSMLSLFNDNFDFQ----TRDDFVRGLLINEELLDSRI 253
            |         |..|.   |.||......|....|..|...|    |.||..|    |.:  |...
Yeast   275 SFIYFCSFELCQLLK---LGPQSMSRQASFKDPFTGNQQQQNPPTTDDDEDR----NHD--DDDD 330

  Fly   254 YVALLPAAQ--YAHKVNNW--------PAYQLVSRDIINR-WAY--PFVPDIGLYKLQQEYVF-- 303
            |.....:.|  |..|.|:.        .:...|.||:..| |.:  |..| ||::.|..|.:|
Yeast   331 YKPSATSIQPTYFKKKNDLILDPINCNKSLSKVFRDLSRRSWQHSKPREP-IGIFILPNETLFIR 394

  Fly   304 -HKDNIYKSPEAHVSKV---------------ALLQNVVIEAGSHVDSGSVISDSVIGANCRIGK 352
             :..|.|......|.|:               |:..:.:::....:.:.|.:..||:|....||.
Yeast   395 ANNLNAYMDANRFVLKIKSQTMFTKNIQIQSAAIGADAIVDPKCQISAHSNVKMSVLGTQANIGS 459

  Fly   353 NCRLTNAFLMADVTVMDNCRLEHCVVGEGAIINEDCDVSAGCVLGAKSVLPAK-----KTLAKTL 412
            .||:..:.|...|.:.|...||:|::|..|.|...|.:| .|.:....|:..|     :|||...
Yeast   460 RCRVAGSLLFPGVHLGDEVILENCIIGPMAKIGSKCKLS-NCYIEGHYVVEPKNNFKGETLANVY 523

  Fly   413 ITRTPSRRRSDDEVVVELKSIGPHAYIVSDLTTGDPEDSECED 455
            :...     .:||::.:...|...:.|..:..:.|..|.:.:|
Yeast   524 LDED-----EEDELIYDDSVIAGESEIAEETDSDDRSDEDSDD 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	54/287 (19%)
		GCD1	22..409	CDD:224129	103/499 (21%)
		LbetaH	326..397	CDD:294107	20/70 (29%)
		W2_eIF2B_epsilon	499..659	CDD:211396
GCD1	NP_014903.1	eIF-2B_gamma_N	3..285	CDD:133041	49/269 (18%)
GCD1	NP_014903.1	LbH_eIF2B_gamma_C	433..513	CDD:100057	22/80 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810