DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bepsilon and AT4G18300

DIOPT Version :9

Sequence 1:	NP_569961.2	Gene:	eIF2Bepsilon / 31156	FlyBaseID:	FBgn0023512	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_193564.1	Gene:	AT4G18300 / 827556	AraportID:	AT4G18300	Length:	709	Species:	Arabidopsis thaliana

Alignment Length:	727	Identity:	198/727 - (27%)
Similarity:	353/727 - (48%)	Gaps:	106/727 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KEIVQAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIRE 70
            ::.:||:|:||:....|:.::.|....|||:||:.|:||.|..|..:|:|||||:...:.|.|.:
plant    21 RQRLQAILLADSFTTQFRSITLERPKVLLPIVNIPMIDYTLAWLESAGIEEVFVFCCAHSSQIID 85

  Fly    71 HIRAGIATDAAWSFK----MTVHVIGGEGCRCFGDAMRDL----DNKALIRGHFILLGADTVTNA 127
            :::     .:.|..:    :.|..|........|||:|.:    ...:.|:|.|:|:..|||:|.
plant    86 YLK-----KSEWYTRPNPNLLVRTIVSHNSTSVGDALRYIYEQQTETSQIQGDFVLVSGDTVSNM 145

  Fly   128 DLRPVLEQHKRQAKFDKGTAATLVFKECANNVRTGNEVLIAVDRRNDRLHYHQRLRMHHKENRYQ 192
            .|..:::||:.:.|.|:....|:|||:.:......:::.:|||....:|       :|::|...:
plant   146 PLADLIQQHRDRKKKDEKAIMTMVFKKQSRLGIGSDQLFVAVDPLTKQL-------LHYEECNSR 203

  Fly   193 ---LPLDVFLGNSCVALHHNLLDPQIAIGSPSMLSLFNDNFDFQ-TRDDFVRGLLINEELLDSRI 253
               ..||..|.:|.| |..::.|..|.|.||.:||||.||||:| .|..||.|||: ::::..:|
plant   204 GGDFCLDKSLLDSTV-LCSDMQDCYIDICSPEVLSLFEDNFDYQHMRRHFVNGLLV-DDIMGYKI 266

  Fly   254 YVALLPAAQYAHKVNNWPAYQLVSRDIINRWAYPFVPDIGLYKLQQEYVFHKDNIYKSPEA---H 315
            :...:.::.||.:::|..:|..||:|||.||.||:||:|. :...:.....:..||::.:|   |
plant   267 FTHEIQSSCYAARIDNLRSYDTVSKDIIQRWTYPYVPNID-FSGNRPVKLGRRGIYRASDAVQSH 330

  Fly   316 VSKVALLQNVVIEAGSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHCVVGE 380
            .:.|.  .:.||..|:.:.:|..|.:||||..|.||.|..:..:::..:||:.|.|.:.:.:|.:
plant   331 TADVG--ASTVIGYGTKIGNGGKIYNSVIGNGCCIGSNVVIQGSYIWNNVTIEDGCEIRNAIVCD 393

  Fly   381 ------GAIINEDCDVSAGCVLGAKSVLPAKKTLAKTLITRTPSRRRSDDEVVVELKSIG--PHA 437
                  ||::.....:|...|:|...|:||   .:|..:.:.|:...||:|:.....|.|  .|:
plant   394 GVKVRAGAVLQPGVVLSFSVVVGRDFVVPA---YSKVSLLQQPTTEDSDEELEYADSSSGTADHS 455

  Fly   438 YIVSDLTTGDPEDSECEDLLPQ---------------------QPLSIPKMGDLLAPLDEISYCS 481
            ..:::|..    :|:..:|.|.                     .|:.:.|:.|:...:|:
plant   456 SGLNNLQI----ESKASELGPDGAGYIWEICDSAHDEEWKHSVVPIPMDKLADITGAMDD----- 511

  Fly   482 DFSEDDEDASRAVTP----LPDDTNI-----------FLGEVIDSLTRGFREKSNPDFLVLEINS 531
            |..|||     .|.|    |..||:|           |..||.:.......:.:..|.::..|||
plant   512 DDIEDD-----IVVPPSGELKSDTDIINTDANDSYGDFEREVEEEFLSAVEKDNKADIVIPLINS 571

  Fly   532 SRYAYNMSLKEVNFNVVKAVFGMQ---SIVEPANDNVLVAINA--AFKQLGPVVSNYIKSEDSMM 591
            .|.||||.    :.:...|||...   ::..|.|....:..||  ...:...|:..|:|..|:.:
plant   572 HRLAYNMD----SADCAGAVFYSMMRLAVKSPHNSATELYRNAMGVITKWKGVLGFYLKQTDAQI 632

  Fly   592 DCLKALEDVYEENHLVRGKISQIVHYLYDKDFVSESAIQAW---YAQLDEEEHAHLRQSLAKLVA 653
            :.:...|::.:|:..:....::::.:|||||.|.|.||..|   .|..|:.:..:|.: ....:.
plant   633 EVIMKFEEMCQESEELSPLFAKLLPFLYDKDVVQEDAILRWGEEKAGADDCDKVYLNK-CESFIK 696

  Fly   654 WLDQSSEEDDDE 665
            ||.::|||::::
plant   697 WLKEASEEEEED 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	66/224 (29%)
		GCD1	22..409	CDD:224129	124/407 (30%)
		LbetaH	326..397	CDD:294107	22/76 (29%)
		W2_eIF2B_epsilon	499..659	CDD:211396	43/178 (24%)
AT4G18300	NP_193564.1	eIF-2B_epsilon_N	24..236	CDD:133040	66/224 (29%)
		LbH_eIF2B_epsilon	339..417	CDD:100061	22/77 (29%)
		W2_eIF2B_epsilon	539..702	CDD:211396	40/167 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	86	1.000	Domainoid score	I2784
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2903
Inparanoid	1	1.050	255	1.000	Inparanoid score	I1005
OMA	1	1.010	-	-		QHG54474
OrthoDB	1	1.010	-	-		D369837at2759
OrthoFinder	1	1.000	-	-		FOG0003779
OrthoInspector	1	1.000	-	-		otm2874
orthoMCL	1	0.900	-	-		OOG6_101778
Panther	1	1.100	-	-	O	PTHR45887
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2634
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840