DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bepsilon and AT3G02270

DIOPT Version :9

Sequence 1:	NP_569961.2	Gene:	eIF2Bepsilon / 31156	FlyBaseID:	FBgn0023512	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_186876.1	Gene:	AT3G02270 / 821200	AraportID:	AT3G02270	Length:	676	Species:	Arabidopsis thaliana

Alignment Length:	705	Identity:	200/705 - (28%)
Similarity:	346/705 - (49%)	Gaps:	92/705 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QFEKEIVQAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSS 67
            |..::.:||:|:||:......||:.|....||||||:.|:||.|..|..:|:|||||:.|:   .
plant    19 QSRRQRLQAILLADSFATKLLPLTLERPNVLLPLVNIPMIDYTLAWLESAGIEEVFVFCSM---Q 80

  Fly    68 IREHIRAGIATDAAW-SFK-MTVHVI-GGEGCRCFGDAMRDLDNKAL----IRGHFILLGADTVT 125
            :.:::     .::.| |.| .||..| ..:.....|||:|.:..:.:    |:|.|:|:....|:
plant    81 VIDYL-----NNSDWYSHKDFTVKTIESPQNSTSAGDALRYIYEQQIETSQIQGDFVLVNGCIVS 140

  Fly   126 NADLRPVLEQHKRQAKFDKGTAATLVFKECANNVRTGNEVLIAVDRRNDRLHYHQRLRMHHKENR 190
            |..|..::::|:.:.|.|:....|:|.::   ::.|.:::.|||:....:|.|:.       |:.
plant   141 NMPLTQLIQEHRDRKKKDEKAIMTMVIRQ---SLITDHQLFIAVNPLTKQLLYYD-------EDN 195

  Fly   191 YQLPLDVFLGNSCVALHHNLLDPQIAIGSPSMLSLFNDNFDFQ-TRDDFVRGLLINEELLDSRIY 254
            ......:...|..|.|..::.|..|.|.|..:||||.||||:| .|.|||.|:|. ::::..:|:
plant   196 ICFDKSLLDRNPSVLLCSDMQDCYIDICSLEVLSLFVDNFDYQHMRCDFVEGVLA-DDIIGYKIF 259

  Fly   255 VALLPAAQYAHKVNNWPAYQLVSRDIINRWAYPFVPDIGL-----YKLQQEYVFHKDNIYKSPEA 314
            ...:.:. ||.::.|:.:|.:||:|||.|..:|:|||:..     .||:::.::...:..:.|.|
plant   260 THEISSC-YASRIENFRSYDMVSKDIIQRRTFPYVPDMKFSGNRTLKLERQGIYKASDATQLPSA 323

  Fly   315 HVSKVALLQNVVIEAGSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHCVVG 379
            ||.     .:.||...:::.||:.|.:||||..|.||.|..:..:::..:|||.|.|.:.:.:|.
plant   324 HVG-----ASYVIGHATNIGSGTKILNSVIGNGCSIGSNVVIQGSYIWNNVTVEDGCEIRNAIVC 383

  Fly   380 E------GAIINEDCDVSAGCVLGAKSVLPAKKTLAKTLITRTPSRRRSDDE-----VVVELKS- 432
            :      |||:.....:|...|:|...|:||   .::..:.|.|....||:|     |.::::|
plant   384 DEVKVCAGAIVKPGVVLSFKVVVGRDFVVPA---YSQVSLLRQPMEEDSDEENLLSGVDLQMESK 445

  Fly   433 --IGPHAYIVSDLTTGDPEDSECEDLLPQQPLSIPKMGDLLAPLDEISYCSDFSEDDED----AS 491
              :....||..         ..|||........|||  |.||.:  |....|...|||.    :.
plant   446 LGLDGAGYIWR---------QACEDEWKHSVPPIPK--DKLAEI--IKAIDDDDTDDESVVTTSG 497

  Fly   492 RAVTPLPDDTNIFLGEVIDSLTRGFREKSNPDFLVLEINSSRYAYNMSLKEVNFNVVKAVFGMQS 556
            .|.|.:.:|...|..||..:..|...|....|..||||||.|.:|||.    :.:...|:|  .|
plant   498 DANTSINNDLFDFEREVDGTFLRAVEENIVADLAVLEINSLRLSYNME----SAHCAGAIF--YS 556

  Fly   557 IVEPANDNVLVAINAAFKQLGPVVSN-------YIKSEDSMMDCLKALEDVYEEN-HLVRGKISQ 613
            :::.|......:||..::....:::.       |:|..|..::.:..||::.||: |.:....:.
plant   557 MMKLAVSTPHSSINDLYRNASSIITRWKGLLGFYVKKSDEQIEVISRLEEMCEESAHELGTLFAH 621

  Fly   614 IVHYLYDK--DFVSESAIQAW---YAQLDEEEHAHLRQSLAKLVAWLDQSSEEDD 663
            |:.|:|::  |.:.|.||..|   .|..||.:..:|:| ....:.||.::|:::|
plant   622 ILRYMYEEENDLLQEVAILRWSDEKAGADESDKVYLKQ-CEPFITWLKETSDDED 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	62/220 (28%)
		GCD1	22..409	CDD:224129	121/405 (30%)
		LbetaH	326..397	CDD:294107	24/76 (32%)
		W2_eIF2B_epsilon	499..659	CDD:211396	46/172 (27%)
AT3G02270	NP_186876.1	eIF-2B_epsilon_N	25..228	CDD:133040	62/220 (28%)
		GCD1	26..407	CDD:224129	122/405 (30%)
		LbH_eIF2B_epsilon	330..408	CDD:100061	24/77 (31%)
		W2_eIF2B_epsilon	509..675	CDD:211396	46/172 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	86	1.000	Domainoid score	I2784
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2903
Inparanoid	1	1.050	255	1.000	Inparanoid score	I1005
OMA	1	1.010	-	-		QHG54474
OrthoDB	1	1.010	-	-		D369837at2759
OrthoFinder	1	1.000	-	-		FOG0003779
OrthoInspector	1	1.000	-	-		otm2874
orthoMCL	1	0.900	-	-		OOG6_101778
Panther	1	1.100	-	-	O	PTHR45887
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2634
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840