Protein Alignment eIF2Bepsilon and eIF2Bepsilon

DIOPT Version :10

• Sequence 1: NP_569961.2
• Gene: eIF2Bepsilon / 31156
• FlyBaseID: FBgn0023512
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: XP_001687758.2
• Gene: eIF2Bepsilon / 5666778
• VectorBaseID: AGAMI1_012238
• Length: 673
• Species: Anopheles gambiae
• Alignment Length: 666
• Identity: 298/666 - (44%)
• Similarity: 412/666 - (61%)
• Gaps: 10/666 - (1%)

  Fly     6 KEIVQAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIRE 70
            ||||||::|||:...||:|.:.....||||:.||.:::|.|..|||:|||||.|:.|.:...::.
Mosquito    10 KEIVQAIVIADSYNDNFQPFTSTKPLALLPVANVPLIEYTLETLNRNGVEEVIVFCSSHIDQVKR 74

  Fly    71 HIRAGIATDAAWSFKMTVHVIGGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRPVLEQ 135
            ||....|....||..|.|.::..|.||..|:|:||||.:..|||..:|||.::||||||..:||:
Mosquito    75 HIADRQAARCTWSTGMRVSIVSSEACRSIGEAIRDLDARNTIRGSVLLLGVESVTNADLAALLEE 139

  Fly   136 HKRQAKFDKGTAATLVFKECANNVRTGNEVLIAVDRRNDRLHYHQRLRMHHKENRYQLPLDVFLG 200
            |||.||.|:|...|:|:||....:|||||||:|.|....||.|||||..|.:|..::||||:||.
Mosquito   140 HKRLAKVDRGAVMTVVYKEGLRRMRTGNEVLVAHDPTTRRLLYHQRLAQHERERSFELPLDLFLA 204

  Fly   201 NSCVALHHNLLDPQIAIGSPSMLSLFNDNFDFQTRDDFVRGLLINEELLDSRIYVALLPAAQYAH 265
            |..||:.|.|||||||:.|.:.|.||.|||||.||||||||:|||||:|:||||||.|...:||.
Mosquito   205 NRDVAVCHGLLDPQIAVCSQAALPLFADNFDFLTRDDFVRGVLINEEILNSRIYVAKLAREEYAM 269

  Fly   266 KVNNWPAYQLVSRDIINRWAYPFVPDIGLYKLQQEYVFHKDNIYKSPEAHVSKVALLQ-NVVIEA 329
            :||||.:|.|||.|:||||.||.|||..:.:.:|:|...::|:|:.....:|:...|. ::|:..
Mosquito   270 RVNNWQSYHLVSLDVINRWVYPLVPDTAISEFRQQYKHFRNNVYRHRNVRLSRSCELDGDLVVGE 334

  Fly   330 GSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHCVVGEGAIINEDCDVSAGC 394
            ...:..|:.:..||:|..||||:|||:.|:||:..|||.|...|.|||:.....:...|.:..|.
Mosquito   335 ECEIREGTYLRQSVVGRGCRIGRNCRIVNSFLLEGVTVGDGTVLSHCVLERAVTVGSRCTIEPGT 399

  Fly   395 VLGAKSVLPAKKTLAKTLITRTPSRRRSDDEVVVELKSIGPHAYIVSDLTTGDPEDSECEDLLPQ 459
            |||....:|...|::..|:  ..|...:|:.....::.|...||.:..|...|.:..|.|....|
Mosquito   400 VLGEGVEIPDGLTVSGLLL--QASEPAADEWGTTPVEKIADRAYTIPVLDEEDSDSDEEEGGSGQ 462

  Fly   460 QPLSIPKMGDLLAPLDEISYCSDFSEDDEDA-SRAVTPLPDDTNIFLGEVIDSLTRGFREKSNPD 523
            ..|:.|   ..:|||.|....|.:...||:. |...:|:|:|.||||.||::||.||..||||.:
Mosquito   463 PALNQP---HAIAPLPERYPASVYEPSDEECDSGPASPVPEDANIFLSEVVESLKRGLAEKSNAE 524

  Fly   524 FLVLEINSSRYAYNMSLKEVNFNVVKAVFGMQSIVEPANDNVLVAINAAFKQLGPVVSNYIKSED 588
            :|:||||||||||||:|.|||:.||||:..:....:....|.:..:.......|.|..|||:..|
Mosquito   525 YLILEINSSRYAYNMALCEVNYYVVKAILQIMLQQDGVATNTVGTLRRLLAYFGVVFRNYIRDRD 589

  Fly   589 SMMDCLKALEDVYEENHLVRGKISQIVHYLYDKDFVSESAIQAWYAQLDEEEHAHLRQSLAKLVA 653
            :|||||||||::...:..||.|:.|:|||||:.|.:.|..|..||..|.:   |.|:.:|:|||.
Mosquito   590 AMMDCLKALEEMCPASETVRAKLPQLVHYLYEADLIGEQVIIEWYDGLAD---AGLQAALSKLVQ 651

  Fly   654 WLDQSSEEDDDEEDDD 669
            ||.:||||::|::|||
Mosquito   652 WLQESSEEEEDDDDDD 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	104/213 (49%)
		LbetaH	326..397	CDD:469633	26/70 (37%)
		W2_eIF2B_epsilon	499..659	CDD:211396	75/159 (47%)
eIF2Bepsilon	XP_001687758.2	None