Protein Alignment eIF2Bepsilon and eif2b5

DIOPT Version :10

• Sequence 1: NP_569961.2
• Gene: eIF2Bepsilon / 31156
• FlyBaseID: FBgn0023512
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001107069.1
• Gene: eif2b5 / 563613
• ZFINID: ZDB-GENE-030131-5364
• Length: 703
• Species: Danio rerio
• Alignment Length: 707
• Identity: 215/707 - (30%)
• Similarity: 353/707 - (49%)
• Gaps: 70/707 - (9%)

  Fly     5 EKEIVQAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIR 69
            |::.:||||:||:....|.|::.:...|||||.||.|:||.|..|..:||:|.||:.....|.|:
Zfish    21 EEQPLQAVLVADSFNRRFFPITKDQPRALLPLANVSMIDYTLEFLTSTGVQETFVFCCWMSSKIK 85

  Fly    70 EHIRAGIATDAAW---SFKMTVHVIGGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRP 131
            ||:     ..:.|   :....||:|..:..|..||.:||:|.|:|:|..|:|:..|.|:|.|:..
Zfish    86 EHL-----LKSKWCRPTSPNVVHIITSDLYRSLGDVLRDVDAKSLVRSDFLLVYGDVVSNVDVSQ 145

  Fly   132 VLEQHKRQAKFDKGTAA-TLVFKECANNVRT---GNEVLIAVDRRNDRLHYHQRLRMHHKENRYQ 192
            .|::|:::.|.:|..:. |::|||.:...:|   ..::::|:|.::.|:.::||.:   ...|.|
Zfish   146 ALQEHRQRRKMEKNVSVMTMIFKESSPGHKTRCEEEDMIMAIDSKSKRILHYQRAQ---ALKRLQ 207

  Fly   193 LPLDVFLGNSC-VALHHNLLDPQIAIGSPSMLSLFNDNFDFQTRDDFVRGLLINEELLDSRIYVA 256
            .|:::|...|. ..:..:|||..|:|.||.:..||.||||:||::|||||:|::||:|.::|::.
Zfish   208 FPMNIFHSASDEFEIRFDLLDCHISICSPQVAELFTDNFDYQTKNDFVRGILVSEEILGNQIHMH 272

  Fly   257 LLPAAQYAHKVNNWPAYQLVSRDIINRWAYPFVPDIGLYKLQQEYVFH-KDNIYKSPE---AHVS 317
            :.... |..:|:|...|..:|.|:|.||.||..||........:...| :.|:|:.|.   .|.|
Zfish   273 VTKDG-YGARVSNLLMYDTISSDMIRRWIYPITPDANFADQDGQSCTHSRHNVYREPGVSLGHGS 336

  Fly   318 KVALLQNVVIEAGSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHCV----- 377
            ::.  :||:|...:.:.:...||::||||||.||.|..|..|::...|.:.:|.:::..|
Zfish   337 QME--ENVLIGRNTVIGANCSISNTVIGANCVIGDNVTLERAYIWNRVHIANNVKVKQSVICDGV 399

  Fly   378 -VGEGAIINEDCDVSAGCVLGAKSVLPAKKTLAKTLITRTPSRR--RSDDEVV------------ 427
             |..|.::||.|.::...|:|....|||...::    ...|...  ..|||.:
Zfish   400 EVKHGVVLNEQCVLAYNVVVGPDIALPAGTVVS----MHHPDEEDDEDDDEFLSDDNDVSHNKDK 460

  Fly   428 VELKSIGP-------HAYIVSDLTTGDPEDSECEDLLPQQPLSIPKMGDLLAPLDEISYCSDFSE 485
            ::.|...|       ..|.....:..|.|:.|..:.:         .|..|.|..|....|:.||
Zfish   461 IKQKVFNPAEVGSEGKGYRWKSSSLDDTEEDELAECI---------WGLALNPDPESDSESEVSE 516

  Fly   486 DDED-ASRAVTPLPDDTNIFLGEVIDSLTRGFREKSNPDFLVLEINSSRYAYNMSLKEVNFNVVK 549
            ...| .|...:|..||..:|..||..:|.||..|....|.|||||||.:||||::||||...:::
Zfish   517 GSHDPGSHPPSPELDDVKVFQNEVHGTLQRGLDENIGCDNLVLEINSLKYAYNITLKEVMQILMR 581

  Fly   550 AVFGM---QSIVEPANDNVLVAINAAFKQLGPVVSNYIKSEDSMMDCLKALEDVYEENHLVRGKI 611
            .|...   |..||.........:....|:..||..||:|.....||||.::|:|:.|.......:
Zfish   582 VVLEFPLHQQGVEITTAQYSAHLLPLLKKWAPVFKNYVKRPQDQMDCLTSMEEVFLEQDTHWAAL 646

  Fly   612 SQIVHYLYDKDFVSESAIQAWYAQ---LDEEEHAHLRQSLAKLVAWLDQSSEEDDDE 665
            .:::..:|..:.:.|..|..|:.|   .|:.:.......|.|.:.||:::.|..|::
Zfish   647 VKVLMNMYQLEILEEDVIMRWFTQSSTTDKSQKLRTNAGLLKFIQWLEEAEESSDED 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	74/221 (33%)
		LbetaH	326..397	CDD:469633	23/76 (30%)
		W2_eIF2B_epsilon	499..659	CDD:211396	52/165 (32%)
eif2b5	NP_001107069.1	eIF-2B_epsilon_N	25..239	CDD:133040	74/221 (33%)
		LbetaH	<302..>370	CDD:469633	22/69 (32%)
		LbH_eIF2B_epsilon	343..421	CDD:100061	23/77 (30%)
		W2_eIF2B_epsilon	531..693	CDD:211396	50/161 (31%)