DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bepsilon and gmppb

DIOPT Version :9

Sequence 1:	NP_569961.2	Gene:	eIF2Bepsilon / 31156	FlyBaseID:	FBgn0023512	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001003491.2	Gene:	gmppb / 445097	ZFINID:	ZDB-GENE-040801-234	Length:	360	Species:	Danio rerio

Alignment Length:	456	Identity:	88/456 - (19%)
Similarity:	164/456 - (35%)	Gaps:	116/456 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIREHIR 73
            ::|:::........:||:......|:...|..:|.:.:.||.::||..|.:..|.....:...:|
Zfish     1 MKALILVGGYGTRLRPLTLTVPKPLVEFCNKPILLHQVEALVKAGVRHVILAVSYMSELLEREMR 65

  Fly    74 A-----GIATDAAWSFKMTVHVIGGEGCRCFGDAMRDL--DNKALIRGHFILLGADTVTNADLRP 131
            |     ||..    |.......:|..|.....   |:|  ||:.    .|.:|.:|.:.:.....
Zfish    66 AQEQRLGIKI----SLSHEKEPLGTAGPLALA---RELLTDNQE----PFFVLNSDVICDFPFDD 119

  Fly   132 VLEQHKRQAKFDKGTAATLVFKECANNVRTGNEVLIAVDRRNDRLHYHQRLRMHHKENRYQLPLD 196
            :|:.|::.     |...|:|..:.....:.|   ::..:..:.|:|            |:.....
Zfish   120 MLKFHQQH-----GREGTIVVTKVEEPSKYG---VVVYEGDSGRIH------------RFVEKPQ 164

  Fly   197 VFLGNSCVALHHNLLDPQIAIGSPSMLSLFNDNFDFQTRDDFVRGLLINEELLDSRIYVALLPAA 261
            ||:.|.        ::..:.|.||:||                |.:.:....::..|:..:....
Zfish   165 VFVSNK--------INAGMYIFSPAML----------------RRIQLQPTSIEKEIFPVMAEEG 205

  Fly   262 Q-YAHKVNNWPAYQLVSRDIINRWAYPFVPDIGLYK--LQQEYVFHKDNIYKSPEAHVSKVALLQ 323
            | ||.::..:             |.     |||..|  |....::.:....::||...:....|.
Zfish   206 QLYAMELQGF-------------WM-----DIGQPKDFLTGMCMYLQSVRQQAPERLRAGPGFLG 252

  Fly   324 NVVIEAGSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHCVVGEGAIIN--- 385
            ||:::           ..:|||.||.||.|..:.     |.|.:.|..|::.|.:.:||.|.
Zfish   253 NVLVD-----------PTAVIGQNCTIGPNVTIG-----AGVVLEDGVRVKRCTILKGAHIRSHS 301

  Fly   386 --EDCDVSAGCVLGAKSVLPAKKTLAKTLITRTPSRRRSDDEVVVELKSIGPHAYIVSDLTTGDP 448
              |.|.|.....:|....:.....|.:.:|.        :||:.:...::.||    ..:|...|
Zfish   302 WLESCIVGWSSSVGQWVRMENVTVLGEDVIV--------NDELYINGANVLPH----KSITDSVP 354

  Fly   449 E 449
            |
Zfish   355 E 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	41/220 (19%)
		GCD1	22..409	CDD:224129	78/401 (19%)
		LbetaH	326..397	CDD:294107	19/75 (25%)
		W2_eIF2B_epsilon	499..659	CDD:211396
gmppb	NP_001003491.2	GCD1	1..352	CDD:224129	86/451 (19%)
		M1P_guanylylT_B_like_N	1..233	CDD:133047	54/304 (18%)
		LbetaH	255..334	CDD:294107	22/102 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810