Protein Alignment eIF2Bepsilon and eif2b3

DIOPT Version :9

• Sequence 1: NP_569961.2
• Gene: eIF2Bepsilon / 31156
• FlyBaseID: FBgn0023512
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_957368.1
• Gene: eif2b3 / 394049
• ZFINID: ZDB-GENE-040426-1039
• Length: 453
• Species: Danio rerio
• Alignment Length: 486
• Identity: 105/486 - (21%)
• Similarity: 170/486 - (34%)
• Gaps: 155/486 - (31%)

  Fly     9 VQAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIREHIR 73
            :||||:|.........|:......|||:.|..::.|.|..|.|.|.|||.|.|:       :.::
Zfish     3 LQAVLMAAGGGSRMMDLTYNTPKPLLPVGNKPLIWYPLNLLERVGFEEVIVITT-------KEVQ 60

  Fly    74 AGIATDAAW----SFKMTVHVIGGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRPVLE 134
            ..::||...    ..|:.|..|..|......||:|.:..|  |:...::|..|.:|:..|..|::
Zfish    61 KALSTDQRLKTDVKMKLDVVCIQEEADMGTADALRHIQQK--IKTDILVLSCDLITDVALHEVVD 123

  Fly   135 QHKRQAKFDKGTAATLVFK--ECANNV-------RTGNE-VLIAVDRRNDRLHYHQRLRMHHKEN 189
            ..:..    ..|.:.|:.|  |....|       :.|.: ..:.||....||.:        ..|
Zfish   124 LFRAH----NATLSMLMSKVHEFTETVPGQKGKKKAGEQRDFVGVDVTGKRLLF--------MAN 176

  Fly   190 RYQLPLDVFLGNSCVALH------HNLLDPQI----------AIGSPSMLSLFNDNFDFQTRDDF 238
            ...|...:.|..|.:..|      ..|||..:          .:.:.|:.|:..:...:..|..|
Zfish   177 EADLEEGLVLRKSIMRKHPRMFIKTGLLDAHLYCLKRSVVDFLVHNKSVTSIRGELVPYLVRKQF 241

  Fly   239 VRGL------------------LINEELLDSRIYVALLPAAQ----------------------- 262
            .:.|                  .||.:||.:....|||..|:
Zfish   242 SKSLNSQHVTEDSEKNQKQQEAHINMDLLSTSKDEALLQLARERSCWNDHRGDMSEAYHGGKIRC 306

  Fly   263 YAH--------KVNNWPAYQLVSRDIINRWAYPFVPDIGLYKLQQEYVFHKDNIYKSPEAHVSKV 319
            |.|        :||...||...:|         .||     ||.:|...|       |.|.||:.
Zfish   307 YVHIMEDGMCYRVNTLAAYIEANR---------VVP-----KLFEEPPIH-------PTAVVSER 350

  Fly   320 ALLQNVVIEAGSHVDSGSVISDSVIGANCRIG-----------------KNCRLTNAFLMADVTV 367
            :|                |.|||:||.:|:|.                 :..::||:.:|..||:
Zfish   351 SL----------------VGSDSIIGPSCQISDKTSIKRSNVGTSTVIKEKVKITNSIIMNGVTI 399

  Fly   368 MDNCRLEHCVVGEGAIINEDCDVSAGCVLGA 398
            .:.|.::..|:...|:|....|:.. |::|:
Zfish   400 EEGCNIQGSVICSHAVIGRGADIKY-CLVGS 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	55/243 (23%)
		GCD1	22..409	CDD:224129	100/473 (21%)
		LbetaH	326..397	CDD:294107	19/87 (22%)
		W2_eIF2B_epsilon	499..659	CDD:211396
eif2b3	NP_957368.1	GCD1	2..430	CDD:224129	105/486 (22%)
		eIF-2B_gamma_N	3..216	CDD:133041	54/233 (23%)
		LbH_eIF2B_gamma_C	358..438	CDD:100057	16/73 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810