DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bepsilon and GMPPA

DIOPT Version :9

Sequence 1:	NP_569961.2	Gene:	eIF2Bepsilon / 31156	FlyBaseID:	FBgn0023512	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001361223.1	Gene:	GMPPA / 29926	HGNCID:	22923	Length:	420	Species:	Homo sapiens

Alignment Length:	493	Identity:	101/493 - (20%)
Similarity:	176/493 - (35%)	Gaps:	134/493 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 FKPLSDEGSTALLPLVNVRMLDYALMALNR-SGVEEVFVYTSLYR--SSIREHIRAGIATDAAWS 83
            |:|||.|....|.|:..|.|:.:.:.|..: .|::|:.: ...|:  ..:.:.:.|     |...
Human    17 FRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILL-IGFYQPDEPLTQFLEA-----AQQE 75

  Fly    84 FKMTVHVI-------GGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRPVLEQHKRQAK 141
            |.:.|..:       .|.|...|.|.:.....:|     |.:|.||..::..|..:||.|:||..
Human    76 FNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEA-----FFVLNADVCSDFPLSAMLEAHRRQRH 135

  Fly   142 FDKGTAATLVFKECANNVRTGN-EVLIAVDRRNDRLHYHQRLRMHHKENRYQLPLDVFLGNSCVA 205
                  ..|:....||..::.| ..::...:.::.|||.::            | ..|:.
Human   136 ------PFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEK------------P-STFIS----- 176

  Fly   206 LHHNLLDPQIAIGSPSMLSLFNDNFDFQTRDDFVRGLLINEE---------LLDSRIYVALLPAA 261
               ::::..|.:.||..|....|.|....:|    |.|.:..         .|:..::.||....
Human   177 ---DIINCGIYLFSPEALKPLRDVFQRNQQD----GQLEDSPGLWPGAGTIRLEQDVFSALAGQG 234

  Fly   262 Q-YAHKVNN-WPAYQ------LVSRDIINRWAYPFVPDIGLYKLQQEYVFHKDNIYKSPEAHVSK 318
            | |.|..:. |...:      ..||..::|:.......:..:.....::  :.|:|..|.|.|:.
Human   235 QIYVHLTDGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWI--RGNVYIHPTAKVAP 297

  Fly   319 VALLQNVVIEAGSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHCVVGEGAI 383
            .|                      |:|.|..|||.           |||.:..||...:|..||.
Human   298 SA----------------------VLGPNVSIGKG-----------VTVGEGVRLRESIVLHGAT 329

  Fly   384 INEDCDVSAGCVLGAKSVLPAKKTLAK-TLITRTPS-------RRRSDDEVVVELKSIGPHAYIV 440
            :.|..     |||  .|::....|:.: ..:..|||       |.|.|.|.:.:...:.|...|:
Human   330 LQEHT-----CVL--HSIVGWGSTVGRWARVEGTPSDPNPNDPRARMDSESLFKDGKLLPAITIL 387

  Fly   441 SDLTTGDPEDSECEDLLPQQPLSIPKMGDLLAPLDEIS 478
            .           |...:|.:.|.   :..::.|..|:|
Human   388 G-----------CRVRIPAEVLI---LNSIVLPHKELS 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	44/211 (21%)
		GCD1	22..409	CDD:224129	86/414 (21%)
		LbetaH	326..397	CDD:294107	17/70 (24%)
		W2_eIF2B_epsilon	499..659	CDD:211396
GMPPA	NP_001361223.1	M1P_guanylylT_A_like_N	4..261	CDD:133050	59/285 (21%)
GMPPA	NP_001361223.1	LbetaH	289..355	CDD:412191	24/105 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810