DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bepsilon and GMPPB

DIOPT Version :9

Sequence 1:	NP_569961.2	Gene:	eIF2Bepsilon / 31156	FlyBaseID:	FBgn0023512	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_037466.3	Gene:	GMPPB / 29925	HGNCID:	22932	Length:	387	Species:	Homo sapiens

Alignment Length:	469	Identity:	88/469 - (18%)
Similarity:	166/469 - (35%)	Gaps:	131/469 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIRE--- 70
            ::|:::........:||:......|:...|..:|.:.:.||..:||:.|.:..| |.|.:.|
Human     1 MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVS-YMSQVLEKEM 64

  Fly    71 ---HIRAGIATDAAWSFKMTVHVIGGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRPV 132
               ..|.||..    |.......:|..|.....   |||.::.  ...|.:|.:|.:.:...:.:
Human    65 KAQEQRLGIRI----SMSHEEEPLGTAGPLALA---RDLLSET--ADPFFVLNSDVICDFPFQAM 120

  Fly   133 LEQHKRQAKFDKGTAATLVFKECANNVRTGNEVLIAVDRRNDRLHYHQRLRMHHKENRYQLPLDV 197
            ::.|:..     |...:::..:.....:.|   ::..:....|:|            |:.....|
Human   121 VQFHRHH-----GQEGSILVTKVEEPSKYG---VVVCEADTGRIH------------RFVEKPQV 165

  Fly   198 FLGNSCVALHHNLLDPQIAIGSPSMLSLFNDNFDFQTRDDFVRGLLINEELLDSRIYVALLPAAQ 262
            |:.|.        ::..:.|.||::|                :.:.:....::..::..:....|
Human   166 FVSNK--------INAGMYILSPAVL----------------QRIQLQPTSIEKEVFPIMAKEGQ 206

  Fly   263 -YAHKVNNWPAYQLVSRDIINRWAYPFVPDIGLYK--LQQEYVFHKDNIYKSPEAHVSKVALLQN 324
             ||.::..:             |.     |||..|  |....:|.:....|.||...|...::.|
Human   207 LYAMELQGF-------------WM-----DIGQPKDFLTGMCLFLQSLRQKQPERLCSGPGIVGN 253

  Fly   325 VVIEAGSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMAD------VTVMDNCR------LEHCV 377
            |:::..:.           ||.||.||.|..|....::.|      .||:.:.|      ||.|:
Human   254 VLVDPSAR-----------IGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCI 307

  Fly   378 VGEGAIINEDCDVSAGCVLGAK-----SVLPAK------------KTLAKTLITRTPSRRRSDDE 425
            ||....:.:...:.||  ||.:     :.||.|            ..|.:.:|.        :||
Human   308 VGWRCRVGQWVSLWAG--LGGERGGECACLPDKAYPLLEVRMENVTVLGEDVIV--------NDE 362

  Fly   426 VVVELKSIGPHAYI 439
            :.:...|:.||..|
Human   363 LYLNGASVLPHKSI 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	39/219 (18%)
		GCD1	22..409	CDD:224129	79/424 (19%)
		LbetaH	326..397	CDD:294107	19/82 (23%)
		W2_eIF2B_epsilon	499..659	CDD:211396
GMPPB	NP_037466.3	M1P_guanylylT_B_like_N	1..233	CDD:133047	49/303 (16%)
GMPPB	NP_037466.3	LbetaH	255..361	CDD:412191	26/126 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810