DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bepsilon and tif225

DIOPT Version :9

Sequence 1:	NP_569961.2	Gene:	eIF2Bepsilon / 31156	FlyBaseID:	FBgn0023512	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_594285.1	Gene:	tif225 / 2542017	PomBaseID:	SPAC8C9.15c	Length:	678	Species:	Schizosaccharomyces pombe

Alignment Length:	699	Identity:	201/699 - (28%)
Similarity:	336/699 - (48%)	Gaps:	70/699 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KEIVQAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIRE 70
            |..:||::::|:..:.|:||:.:....||||.|..:::|....|..:||:||:|:...:...|||
pombe    15 KHALQAIVLSDSYNYRFRPLTLDKPRCLLPLANTPLIEYTFEFLALAGVQEVYVFCCAHAGQIRE 79

  Fly    71 HIRAGIATDAAW---SFKMTVHVIGGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRPV 132
            :|.     .:.|   |...:|:.|........|||:|:||:|.||...|||:..|.|:|..|..|
pombe    80 YIE-----KSKWNLPSSPFSVNTIVSRESLSVGDALRELDSKQLITSDFILVSGDVVSNVPLNEV 139

  Fly   133 LEQHKRQAKFDKGTAATLVFKECA----NNVRTGNEVLIAVDRRNDRLHYHQRLRMHHKENRYQL 193
            |::|:::.:.||....|:|.:|.:    ...||.:.|.:...:.:..:||....|..|   ...:
pombe   140 LKEHRKRREDDKNAIMTMVVREASPFHRTRARTESSVFVIDKKTSQCVHYQANERGKH---YVSM 201

  Fly   194 PLDVFLGNSCVALHHNLLDPQIAIGSPSMLSLFNDNFDFQ-TRDDFVRGLLINEELLDSRIYVAL 257
            ..::|..:..:.:.::|:|.||.|.|..:.:||.:|||:| .|.|||.|:| ..:||..:|: ..
pombe   202 DPEIFNEHEELEVRNDLIDCQIDICSNDVPALFTENFDYQDIRKDFVYGVL-TSDLLGKKIH-CH 264

  Fly   258 LPAAQYAHKVNNWPAYQLVSRDIINRWAYPFVPDIGLYKLQQEYVFHKDNIYKSPEAHVSKVALL 322
            :....||.:|.:...|..:|:|:::||.||||||..|  |.|.:.:.:..|||..:..:::..::
pombe   265 VAKENYAARVRSLQTYDAISKDVLSRWVYPFVPDSNL--LNQTFSYQRHQIYKEEDVVLARSCII 327

  Fly   323 Q-NVVIEAGSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHCVVGEGAIINE 386
            : ..:|.|.:.|...||:::::||.||.||.||.:.:|||..||.:.||||:...::.....|..
pombe   328 KARTLIGAYTKVGDASVVANTIIGRNCTIGSNCSIDSAFLWEDVVIGDNCRIGKAILANSVKIGN 392

  Fly   387 DCD------VSAGCVLGAKSVLPAKKTLAKTLITRTPSRRRSDDEVVVELKSIGP--HAYIVSDL 443
            :|.      |:||.|:|..:::...|.|.   ...:.|:...:|..:|.:...|.  ||
pombe   393 NCSIEDGAIVAAGVVIGDNTIIEKNKRLT---TFESHSQGTLNDPSLVGIGGRGQEYHA------ 448

  Fly   444 TTGDPEDSECEDLLPQQPLSIPKMGDLLAPLDEISYCSDFSEDD---------EDASRAVTPLPD 499
                .|||:.|....:....|....:|.....|.|..|..||:|         .|::..:.....
pombe   449 ----EEDSDDEGEFMEASGLIESTNELHLSDSESSETSSSSEEDMEFIPFSARRDSANTINSEDF 509

  Fly   500 DTNIFLGEVIDSLTRGFREKSNPDFLVLEINSSRYAYNMSLKEVNFNVVKAVFG--MQSIVEPAN 562
            |...|..|...||.|.|.|....|...||:|:.|.|.|.:..||...:|.|:..  |...|.|..
pombe   510 DEGDFNKEAQQSLERAFEENHQIDIAALELNTLRMAMNANYHEVRSAIVLALLRRIMHLDVSPKE 574

  Fly   563 DNVLVAINAAFKQLGPVVSNYIKSEDSMMDCLKALEDVYEENHLVRGKIS----QIVHYLYDKDF 623
                 |:.....:.||:::....|.:..:|.:..|     :.:.||..::    |::.|.|..:.
pombe   575 -----ALAKVMTRWGPLLAKLTFSHEEQVDNVLTL-----QKYCVRLSMTRHFLQLLGYFYQLEI 629

  Fly   624 VSESAIQAWYA--QLDEEEHAHLRQSLAK-LVAWLDQSSEEDDDEEDDD 669
            ..|:|||.||:  :..|.|.|.||.:..| .|.||:.:..|.:.||..:
pombe   630 AEENAIQEWYSDPRSSEGELAALRDAGGKQFVDWLNTAESESESEEGSE 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	64/220 (29%)
		GCD1	22..409	CDD:224129	126/401 (31%)
		LbetaH	326..397	CDD:294107	28/76 (37%)
		W2_eIF2B_epsilon	499..659	CDD:211396	48/168 (29%)
tif225	NP_594285.1	eIF-2B_epsilon_N	18..231	CDD:133040	64/220 (29%)
		LbH_eIF2B_epsilon	332..410	CDD:100061	28/77 (36%)
		lipid_A_lpxA	382..>452	CDD:188173	16/82 (20%)
		W2_eIF2B_epsilon	510..667	CDD:211396	48/166 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	78	1.000	Domainoid score	I2407
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2903
Inparanoid	1	1.050	264	1.000	Inparanoid score	I734
OMA	1	1.010	-	-		QHG54474
OrthoFinder	1	1.000	-	-		FOG0003779
OrthoInspector	1	1.000	-	-		oto100785
orthoMCL	1	0.900	-	-		OOG6_101778
Panther	1	1.100	-	-	LDO	PTHR45887
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R374
SonicParanoid	1	1.000	-	-		X2634
TreeFam	1	0.960	-	-
	14	13.860