DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF2Bepsilon and Eif2b5

DIOPT Version :9

Sequence 1:	NP_569961.2	Gene:	eIF2Bepsilon / 31156	FlyBaseID:	FBgn0023512	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_758469.1	Gene:	Eif2b5 / 224045	MGIID:	2446176	Length:	717	Species:	Mus musculus

Alignment Length:	704	Identity:	226/704 - (32%)
Similarity:	363/704 - (51%)	Gaps:	69/704 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIREHIR 73
            :||||:||:....|.|:|.:....||||.||.::||.|..|..:||:|.||:.....:.|:||::
Mouse    39 LQAVLVADSFNRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAAQIKEHLQ 103

  Fly    74 AGIATDAAWSFKMT---VHVIGGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRPVLEQ 135
                 .:.|....:   |.:|..|..|..||.:||:|.|||:|..|:|:..|.::|.::...||:
Mouse   104 -----KSKWCHPTSPNVVRIITSELYRSLGDVLRDVDAKALVRSDFLLIYGDVISNINICRALEE 163

  Fly   136 HKRQAKFDKGTAA-TLVFKECANNVRT---GNEVLIAVDRRNDR-LHYH--QRLRMHHKENRYQL 193
            |:.:.|.:|..:. |:||||.:.:..|   .:.|::|||...:| ||:.  |.||      |:..
Mouse   164 HRLRRKLEKNVSVMTMVFKESSPSHPTRCHEDNVVMAVDSATNRVLHFQKTQGLR------RFSF 222

  Fly   194 PLDVFLGN-SCVALHHNLLDPQIAIGSPSMLSLFNDNFDFQTRDDFVRGLLINEELLDSRIYVAL 257
            ||.:|.|: ..|.:.::|||..|:|.||.:..||.||||:|||||||||:|:|||:|.::|::.
Mouse   223 PLSLFQGSGDGVEIRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGILMNEEVLGNQIHLH- 286

  Fly   258 LPAAQYAHKVNNWPAYQLVSRDIINRWAYPFVPDIGLY-KLQQEYVFHKDNIYKSPEAHVSKVAL 321
            :...:|..:|:|...|..|..|:|.||.||..|::... ...|.|...:.|||:.||..:...::
Mouse   287 VTTREYGARVSNLHMYSAVCADVIRRWVYPLTPEVNFTDSTTQSYTHSRHNIYRGPEVSLGHGSV 351

  Fly   322 L-QNVVIEAGSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHCVVGEGAIIN 385
            | :||::.||:.:.|...|::||||.||.||.|..|..|:|...|.|....::...::.:.|.:.
Mouse   352 LEENVLLGAGTVIGSNCSITNSVIGPNCHIGDNVVLDQAYLWQGVRVAAGAQIHQSLLCDRAEVK 416

  Fly   386 EDCDVSAGCVLGAKSVLPAKKTLAK-TLITRTPSRRRSDDE--------------VVVELKSIGP 435
            |...:...|||.::.|:....||.: ::|:..|.....|::              ..|:||...|
Mouse   417 ERVKLKPYCVLTSQVVVGPDITLPEGSVISLHPPDAEEDEDDGQFSDDSGADQEKEKVKLKGYNP 481

  Fly   436 -------HAYIVSDLTTGDPEDSECEDLLPQQPLSIPKMGDLLAPLDEISYCSDFSEDDEDA-SR 492
                   ..|:.........||.|....|         .|.::...:|....|:.|.|.|:. ||
Mouse   482 AEVGLEGQGYLWKAEGVNSKEDEELRQSL---------WGLMIKTEEESETESEGSVDPEELDSR 537

  Fly   493 AVTPLPDDTNIFLGEVIDSLTRGFREKSNPDFLVLEINSSRYAYNMSLKEVN--FNVVKAVFGMQ 555
            |.:|..||..:|..||:.:|.||..|..:.:.|||||||.::|||:|||||.  ..:|...|.:|
Mouse   538 AGSPQLDDIRVFQNEVLGTLQRGREENISCENLVLEINSLKHAYNISLKEVMQVLTLVVLEFPLQ 602

  Fly   556 SI---VEPANDNVLVAINAAFKQLGPVVSNYIKSEDSMMDCLKALEDVYEENHLVRGKISQIVHY 617
            .:   ::|  :.....:....|...||:.||||.....::.|.|:||.:.|:..:...:::::..
Mouse   603 QVDGLLDP--NRYCALLLPLLKAWSPVLRNYIKRAADHLEALAAIEDFFLEHETLVTSMAKVLMA 665

  Fly   618 LYDKDFVSESAIQAWYAQ---LDEEEHAHLRQSLAKLVAWLDQSSEEDDDEEDD 668
            .|..:.::|..|.:|::|   .||.:.....|.|.:.:.||.::.||  ..|||
Mouse   666 FYQLEILAEETILSWFSQRDTTDEGQQLRKNQQLQRFIQWLREAEEE--SSEDD 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	79/224 (35%)
		GCD1	22..409	CDD:224129	141/399 (35%)
		LbetaH	326..397	CDD:294107	22/70 (31%)
		W2_eIF2B_epsilon	499..659	CDD:211396	51/167 (31%)
Eif2b5	NP_758469.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		GCD1	38..434	CDD:224129	146/406 (36%)
		eIF-2B_epsilon_N	39..253	CDD:133040	79/224 (35%)
		LbH_eIF2B_epsilon	357..435	CDD:100061	24/77 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..479		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..538		6/20 (30%)
		W2_eIF2B_epsilon	544..707	CDD:211396	50/164 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837802
Domainoid	1	1.000	117	1.000	Domainoid score	I5910
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2903
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2527
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54474
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003779
OrthoInspector	1	1.000	-	-		oto92594
orthoMCL	1	0.900	-	-		OOG6_101778
Panther	1	1.100	-	-	LDO	PTHR45887
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R374
SonicParanoid	1	1.000	-	-		X2634
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790