DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bepsilon and eif-2Bepsilon

DIOPT Version :9

Sequence 1:	NP_569961.2	Gene:	eIF2Bepsilon / 31156	FlyBaseID:	FBgn0023512	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_495841.1	Gene:	eif-2Bepsilon / 174387	WormBaseID:	WBGene00008428	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	760	Identity:	171/760 - (22%)
Similarity:	307/760 - (40%)	Gaps:	204/760 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EKEIVQAVLIADNNVWNFKPLSDE----GSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYR 65
            |:..:.|::|.|.....|.|..:.    |:   :|:.||..:::||..|.|:.|:.|.:..|
Worm    15 EEHPLVAIVILDAFDQRFAPTHESYPCFGT---IPICNVPAINFALSWLMRTEVKNVMLVVS--- 73

  Fly    66 SSIREHIRAGIATDAAWSF---------KMTVHVIGGEGCRCFGDAMRDLDNKALIRGHFILLGA 121
                     |:..|.|.|.         :.||.|.  :|....||.||::.|:.||.|.|:|:..
Worm    74 ---------GLNADHATSVQREWRLAFDEFTVVVC--DGASSVGDCMREIHNRELITGDFMLISN 127

  Fly   122 DT-VTNADLRPVLEQHKRQAKFDKGTAATLVFKECANNVRTGNEVLIAVDRRNDRL------HYH 179
            .| |.::.|...:.:.:::.:.:.....||::    :|......:::.::....:|      :..
Worm   128 PTAVVSSTLSAQISEFRKRRRENPDNVMTLLY----SNRENPEHLVLGINSETSKLMLFPAANSL 188

  Fly   180 QRLRMHHKENRYQLPLDVFLGNSCVALHHNLLDPQIAIGSPSMLSLFNDNFDFQTRDDFVRGLLI 244
            .:|:...|:         |...  |.:..:|....||..|..:.:.|:|||||...||.||.:|.
Worm   189 NQLKASKKD---------FYDE--VDIRRDLTPTGIAFCSRLIATQFSDNFDFVGIDDVVREILS 242

  Fly   245 NEELLDSRIYVALLPAAQYAHKVNNWPAYQLVSRDIINRWAYPFVPDIG----LYKLQQEYVFHK 305
            .:::|...::|.:|...:.|....::.:..|::..::.||.||.||:..    .:......::.:
Worm   243 KDDILGMSVHVEVLSPKERAFCAYDYESLILLNILMLERWFYPLVPENSDPSRYFSANPRNLYLE 307

  Fly   306 DN-------------------IYKSPEAHVSKVALLQNVVIEAGSHVDSGSVISDSVIGANCRIG 351
            :|                   :....:..::..|.::|..|.|.:.:.|.:.|:.|:||.||:||
Worm   308 ENGDEISIKANTWILNNNCSTVCLGVKTDIAYDAFIRNSCIGAHTEISSKTRITSSMIGKNCKIG 372

  Fly   352 KNCRLTNAFLMADVTVMDNCRL-EHCVVGEGAIINEDCDVSAGCVLGAKSVLPAKKTLAKTLITR 415
            :||.:..||:..||.:.:...: :..::|.|.:..::              ||.        |..
Worm   373 ENCVIEYAFIGDDVVIPNGAHIPKESIIGNGVMYPKE--------------LPN--------IQN 415

  Fly   416 TPSRRRSDDEVVVELKSIGPHAYI-VSDLTTGDP----------------EDSECEDLLPQQPLS 463
            |...:.:.:|...|..|..|...: ||....|.|                :|||
Worm   416 TAIFKNAINEETFEKLSSQPIGNVHVSKFRNGGPFWRRSVNGKTNFALEEDDSE----------- 469

  Fly   464 IPKMGDLLAPLDEISYCSDFSEDDEDASRAVTPLPDD-----TNIFLGEVIDSLTRGFR-EKSNP 522
                             |::||.:|:         ||     |.:|..||::|:.:... |.|..
Worm   470 -----------------SEYSESEEE---------DDGVGNSTKMFHDEVLESMQKILESENSLM 508

  Fly   523 DFLVLEINSSRYAYNMSLKEVNFNVVKAVFGMQSIVEPANDNVLVAINAAFKQL-------GPVV 580
            ..|:||||||:.|.|:::.||..||..|...::.             |..|.::       .|:.
Worm   509 RNLILEINSSKLACNVTMDEVARNVFAAFMKLKH-------------NQDFNKMKELIVKWQPLF 560

  Fly   581 SNY---------IKSEDS-----------MMDCLKALEDVYEENHLVRGKISQIVHYLY-DKDFV 624
            .||         :||.|.           .:..|.|:||.::.:.....|...:||||| :.|.:
Worm   561 LNYYKTSAESLKVKSADQKRFELDLKRRCQIQLLLAIEDKFDRDESFGVKAQALVHYLYQEADIL 625

  Fly   625 SESAIQAWYAQLDEEEHAHLRQSLAKLVAWLDQSSEEDDDEEDDD 669
            .|.:|..|...:.||  :.|:..:.|:|.||   .|:||:||.:|
Worm   626 DEDSIIEWAGSIAEE--SKLKGLMKKIVDWL---QEDDDEEESED 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	49/233 (21%)
		GCD1	22..409	CDD:224129	92/430 (21%)
		LbetaH	326..397	CDD:294107	19/71 (27%)
		W2_eIF2B_epsilon	499..659	CDD:211396	52/193 (27%)
eif-2Bepsilon	NP_495841.1	Glyco_tranf_GTA_type	19..218	CDD:386096	48/230 (21%)
		LbetaH	331..404	CDD:381831	20/72 (28%)
		W2_eIF2B_epsilon	484..655	CDD:211396	50/188 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159705
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	139	1.000	Inparanoid score	I3090
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54474
OrthoDB	1	1.010	-	-		D239597at33208
OrthoFinder	1	1.000	-	-		FOG0003779
OrthoInspector	1	1.000	-	-		oto19098
orthoMCL	1	0.900	-	-		OOG6_101778
Panther	1	1.100	-	-	LDO	PTHR45887
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R374
SonicParanoid	1	1.000	-	-		X2634
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.800