Protein Alignment eIF2Bepsilon and eif-2Bgamma

DIOPT Version :10

• Sequence 1: NP_569961.2
• Gene: eIF2Bepsilon / 31156
• FlyBaseID: FBgn0023512
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_495428.1
• Gene: eif-2Bgamma / 174138
• WormBaseID: WBGene00004090
• Length: 404
• Species: Caenorhabditis elegans
• Alignment Length: 458
• Identity: 98/458 - (21%)
• Similarity: 181/458 - (39%)
• Gaps: 99/458 - (21%)

  Fly     9 VQAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIREHIR 73
            :|.:|:..........|:......|||:|.|.|..|.|.:|.|:|:.::.::       :||.::
 Worm     4 MQGILLCSGGGTRMPVLTRHVQKCLLPVVGVPMFLYPLSSLLRTGITDIKIF-------VREVLQ 61

  Fly    74 AGIATDAAWS---FKMTVHV----IGGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRP 131
            ..:..:...|   .|...|:    :..|.   ||.|....::.:.|....:::..|.:::|.|.|
 Worm    62 LTLEKEVKKSKLLEKYPAHIEYICVNQED---FGTADLLKNHHSKITKDALIVSCDFISDASLIP 123

  Fly   132 VLEQHKRQAKFDKGTAATLV---FKECANNVRTGN--------EVLIAVDRRNDRLHYHQRLRMH 185
            :::       |.:.|.:|||   ...|.|....|:        :|:..|:...       :|...
 Worm   124 LVD-------FFRATNSTLVALIADTCVNAPAPGSKSKKPKATDVMAIVESTG-------QLAFL 174

  Fly   186 HKENRYQLP------LDVFLG-------NSC--VALHHNLLDPQIAIGSPSMLSLFNDNFDFQTR 235
            ..::.:..|      |.:|..       |.|  .|:.|.:|   :.:.....:|.|        :
 Worm   175 CGDDDFDAPLVMEKSLKIFPSIKLTSKYNDCHVYAIRHKVL---LNLSKSKHISSF--------K 228

  Fly   236 DDFVRGLLINEEL---LDSRIYVALLPAAQ---YAHKVNNWPAYQLVSRDIINRWAYPFVPDIGL 294
            .||| .|||:::.   .|.:.:...||...   .|| .|...:|..|::.|...
 Worm   229 ADFV-PLLIDKQFEPDSDIKCFAYRLPHENGFVTAH-ANTLGSYFEVNKAIQKS----------- 280

  Fly   295 YKLQQEYVFHKDNI-YKSPE--AHVSKVALLQNVVIEAGSHVDSGSVISDSVIGANCRIGKNCRL 356
            :....||..:..|. ||:.:  ||.|:        ||..:.:|..|||..|.|..|||||:..:|
 Worm   281 FTRLMEYRGNGKNFNYKTDKIAAHESR--------IEESAEIDKDSVIKRSFISDNCRIGEKTKL 337

  Fly   357 TNAFLMADVTVMDNCRLEHCVVGEGAIINEDCDVSAGCVLGAKSVLPAKKTLAKTLITRTPSRRR 421
            ..:.:...|.:.:...:.:.::.:|..|.|:.||: .|::.....:|||..:...::........
 Worm   338 KESIIAKGVVIGNGASISNSIICDGVEIGENADVT-NCIVAKDQKVPAKGKVQNEVVEDGEDEEW 401

  Fly   422 SDD 424
            :||
 Worm   402 TDD 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	47/246 (19%)
		LbetaH	326..397	CDD:469633	21/70 (30%)
		W2_eIF2B_epsilon	499..659	CDD:211396
eif-2Bgamma	NP_495428.1	eIF-2B_gamma_N	4..215	CDD:133041	46/234 (20%)
		GlgC	<207..384	CDD:440217	49/209 (23%)
		LbH_G1P_AT_C_like	307..384	CDD:100046	21/85 (25%)