Protein Alignment eIF2Bepsilon and Eif2b3

DIOPT Version :9

• Sequence 1: NP_569961.2
• Gene: eIF2Bepsilon / 31156
• FlyBaseID: FBgn0023512
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_598293.2
• Gene: Eif2b3 / 171145
• RGDID: 620821
• Length: 452
• Species: Rattus norvegicus
• Alignment Length: 490
• Identity: 102/490 - (20%)
• Similarity: 184/490 - (37%)
• Gaps: 120/490 - (24%)

  Fly    10 QAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIREHIRA 74
            |||::|.........|:......|||:.|..::.|.|..|.|.|.|||.|.|:       :.::.
  Rat     4 QAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTT-------KDVQK 61

  Fly    75 GIATDAAWSFKMTVHVIGGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRPVLE----- 134
            .:..:.....|..:..|..|......|::|.:..|  ::...::||.|.:|:..|..|::
  Rat    62 ALCAEFKMKLKPDIVCIPDEADMGTADSLRHIYPK--LKTDVLVLGCDLITDVALHEVVDLFRAY 124

  Fly   135 -------QHKRQAKFD-----KG---------------TAATLVFKECANNVRTGNEVLI--AVD 170
                   ..|.|...:     ||               |...|:|  .||......|::|  ::.
  Rat   125 DASLAMLMRKGQESTEPVPGQKGKKKTVEQRDFIGVDSTGKRLLF--MANEADLDEELVIKGSIL 187

  Fly   171 RRNDRLHYHQRLRMHHKENRYQLPLDVFLGNSCVALHHNLLDPQIAIGSPSMLSLFNDNFDFQTR 235
            :::.|:|:...|...|.....:..:|..:.|..:....:.|.|.:      :...|:.....|.:
  Rat   188 QKHPRIHFQTGLVDAHLYCLKKYVVDFLMENKSITSIRSELIPYL------VRKQFSSASSQQRQ 246

  Fly   236 DDFVRGLLINEELL----------------DSRIYVALLPAAQYAHKVNNWPAYQLVSRDIINRW 284
            :|       .||.|                |:.:.:|...|...|.:.:.|   :.:||..:..:
  Rat   247 ED-------KEEDLKKKEPKSLDIYSFIKKDNTLTLAPYDACWNAFRRDKW---EDLSRSQVRCY 301

  Fly   285 AYPF-------VPDIGLY--------KL-----QQEYVFHKDNIYKSPEAHVSKVALL-QNVVIE 328
            .:..       |..:|||        ||     .:|.:.|       |.|.::...|: .:.:|.
  Rat   302 VHIMKEGLCSRVSTLGLYMEANRQVPKLLSVLCPEESMIH-------PSAQIANKHLIGADSLIG 359

  Fly   329 AGSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHCVVGEGAIINEDCDVSAG 393
            :.:.|...|.|..||||::|.|.....:||..||..|||.:...:...|:...|::....:: ..
  Rat   360 SDTQVGEKSSIKRSVIGSSCVIRDRVTVTNCLLMNSVTVEEGSSIHGSVICNNAVVEAGAEI-RD 423

  Fly   394 CVLGAKSVLPAKKTLAKTLITRTPSRRRSDDEVVV 428
            |::|:...:.||   ||.:           :||:|
  Rat   424 CLIGSGQRIEAK---AKRM-----------NEVIV 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	50/246 (20%)
		GCD1	22..409	CDD:224129	93/457 (20%)
		LbetaH	326..397	CDD:294107	20/70 (29%)
		W2_eIF2B_epsilon	499..659	CDD:211396
Eif2b3	NP_598293.2	eIF-2B_gamma_N	3..212	CDD:133041	46/218 (21%)
		GCD1	4..447	CDD:224129	102/490 (21%)
		LbH_eIF2B_gamma_C	357..437	CDD:100057	23/83 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810