Protein Alignment eIF2Bepsilon and Eif2b3

DIOPT Version :9

• Sequence 1: NP_569961.2
• Gene: eIF2Bepsilon / 31156
• FlyBaseID: FBgn0023512
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001104747.1
• Gene: Eif2b3 / 108067
• MGIID: 1313286
• Length: 452
• Species: Mus musculus
• Alignment Length: 478
• Identity: 103/478 - (21%)
• Similarity: 184/478 - (38%)
• Gaps: 96/478 - (20%)

  Fly    10 QAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIREHIRA 74
            |||::|.........|:......|||:.|..::.|.|..|.|.|.|||.|.|:       :.::.
Mouse     4 QAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTT-------KDVQK 61

  Fly    75 GIATDAAWSFKMTVHVIGGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRPVLE----- 134
            .:..:.....|:.:..|..|......|::|.:..|  ::...::|..|.:|:..|..|::
Mouse    62 ALCAEFKMKMKLDIVCIPDEADMGTADSLRHIYPK--LKTDVLVLSCDLITDVALHEVVDLFRAY 124

  Fly   135 -------QHKRQAKFD-----KG---------------TAATLVFKECANNVRTGNEVLI--AVD 170
                   ..|.|...:     ||               |...|:|  .||......|::|  ::.
Mouse   125 DASLAMLMRKGQESIEPVPGQKGKKKPVEQRDFIGVDSTGKRLLF--MANEADLDEELVIKGSIL 187

  Fly   171 RRNDRLHYHQRLRMHHKENRYQLPLDVFLGNSCVALHHNLLDPQIAIGSPSMLSLFNDNFDFQTR 235
            :::.|:|:|..|...|.....:..:|..:.|..:....:.|.|.:      :...|:.....|.:
Mouse   188 QKHPRIHFHTGLVDAHLYCLKKYVVDFLMENRSITSIRSELIPYL------VRKQFSSASSQQRQ 246

  Fly   236 DDFVRGLLINEELLDSRIY--------VALLP--AAQYAHKVNNWPAYQLVSRDIINRWAYPF-- 288
            :|....|. .:||....||        :.|.|  |...|.:.:.|   :.:||..:..:.:..
Mouse   247 EDKEEDLK-KKELKSLDIYSFIKKDDTLTLAPYDACWNAFRGDKW---EDLSRSQVRCYVHIMKE 307

  Fly   289 -----VPDIGLY--------KLQQEYVFHKDNIYKSPEAHVSKVALLQNVVIEAGSHVDSGSVIS 340
                 |..:|||        ||.......:..|:.|.:. |:|..:..:.:|...:.:...|.|.
Mouse   308 GLCSRVSTLGLYMEANRQVPKLLSVLCPEESMIHSSAQI-VNKHLIGADSLIGPDTQIGEKSSIK 371

  Fly   341 DSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHCVVGEGAIINEDCDVSAGCVLGAKSVLPAK 405
            .||||::|.|.....:||..||..|||.:...:...|:...|:|....::. .|::|:...:.||
Mouse   372 HSVIGSSCVIRDRTSITNCLLMNSVTVEEGSSIHGSVICNNAVIETGAEIK-NCLVGSGQRIEAK 435

  Fly   406 KTLAKTLITRTPSRRRSDDEVVV 428
               ||.:           :||:|
Mouse   436 ---AKRM-----------NEVIV 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	50/246 (20%)
		GCD1	22..409	CDD:224129	94/445 (21%)
		LbetaH	326..397	CDD:294107	20/70 (29%)
		W2_eIF2B_epsilon	499..659	CDD:211396
Eif2b3	NP_001104747.1	eIF-2B_gamma_N	3..212	CDD:133041	46/218 (21%)
		GCD1	4..447	CDD:224129	103/478 (22%)
		LbH_eIF2B_gamma_C	357..437	CDD:100057	23/83 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810