Protein Alignment eIF2Bepsilon and eif2b5

DIOPT Version :10

• Sequence 1: NP_569961.2
• Gene: eIF2Bepsilon / 31156
• FlyBaseID: FBgn0023512
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: XP_002935185.3
• Gene: eif2b5 / 100487780
• XenbaseID: XB-GENE-986286
• Length: 716
• Species: Xenopus tropicalis
• Alignment Length: 702
• Identity: 213/702 - (30%)
• Similarity: 359/702 - (51%)
• Gaps: 68/702 - (9%)

  Fly     9 VQAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIREHIR 73
            :||||:||:....|.|::.:...||:||.||.::||.|..|..:||:|.||:.....:.|:||:|
 Frog    39 LQAVLVADSFNRRFYPITKDRPRALIPLANVALIDYTLEFLTATGVKETFVFCCWMANDIKEHLR 103

  Fly    74 AGIATDAAW---SFKMTVHVIGGEGCRCFGDAMRDLDNKALIRGHFILLGADTVTNADLRPVLEQ 135
                 ::.|   :....|..:..|..|..||.:||:|.|:|:|..|||:..|.|:|.::...|||
 Frog   104 -----NSKWCRPTSPNVVRFVTSELYRSLGDVLRDVDAKSLVRSDFILVTGDVVSNINIEAALEQ 163

  Fly   136 HKRQAKFDKGTAA-TLVFKECANNVRT---GNEVLIAVDRRNDRLHYHQRLRMHHKENRYQLPLD 196
            |:.:.|.:|..:. |::.||.:...||   .::|:||:|.:..|:..:|:   .....|:..|:.
 Frog   164 HRTRRKLEKNVSVMTMILKESSPGHRTRCQEDDVIIAMDSKTKRVLLYQK---SQGLTRFHFPVS 225

  Fly   197 VFLGNSC-VALHHNLLDPQIAIGSPSMLSLFNDNFDFQTRDDFVRGLLINEELLDSRIYVALLPA 260
            :|..|:. :.|.|:|||..|:|.||.:..||.||||:|||||||||:|:|||:|.::|::. :..
 Frog   226 IFQSNTDEIELRHDLLDCHISICSPQVAELFTDNFDYQTRDDFVRGILVNEEILGNQIHLH-VTQ 289

  Fly   261 AQYAHKVNNWPAYQLVSRDIINRWAYPFVPDIGLYKLQQE---YVFHKDNIYKSPEAHVSKVALL 322
            .:|..:::|...|..|:.||:.||.||..|:...  ..|:   |...:.|||:..:......::|
 Frog   290 EEYGARISNLLMYDAVTSDILRRWLYPLTPETNF--TDQDAHTYTHCRHNIYRGSDVSRGHGSIL 352

  Fly   323 -QNVVIEAGSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHCVVGEGAIINE 386
             :||:|...:.:.|...:|:|.||.||.||....|.|..:...|.:.|:..:::.::....::.:
 Frog   353 RENVLIGTNTTIGSKCSVSNSTIGRNCSIGDRVVLENVHVWDRVHIEDDVTIKNSIICNDVVVKK 417

  Fly   387 DCDVSAGCVLGAKSVL-PAKKTLAKTLIT-RTPSRRRSDDE-----------------VVVELKS 432
            ...::..|||.:|.|: |..:....|:|: ..|....:||:                 .|...|.
 Frog   418 RVQINPYCVLTSKVVIGPDIQLPESTVISLHHPEEDENDDDEFSDDAGAGKQAERMKVKVYNKKE 482

  Fly   433 IGP----HAYIVSDLTTGDPEDSECEDLLPQQPLSIPKMGDLLAPLDEISYCSDFSEDDEDASRA 493
            :|.    :.:..|:|.. :.||.|.:..|....|:..::.|     .|    |:.....:..|..
 Frog   483 VGSEGQGYLWKFSNLAE-EEEDDELQRSLWGLTLNTEEVSD-----SE----SETGSMQQSESHP 537

  Fly   494 VTPLPDDTNIFLGEVIDSLTRGFREKSNPDFLVLEINSSRYAYNMSLKEVNFNVVKAV--FGMQS 556
            .:|:.||..:|..||:.:|.||..|..:.|.|||||||.:||||:||.||...:.|.|  |.:..
 Frog   538 ASPVLDDIKVFQMEVLGTLQRGVEENISCDNLVLEINSLKYAYNISLTEVMQVLSKVVLEFPLHQ 602

  Fly   557 IVEPANDN----VLVAINAAFKQLGPVVSNYIKSEDSMMDCLKALEDVYEENHLVRGKISQIVHY 617
            :....:.|    .|:.:   .|...|:..||||.....:.||.|:|:.:.:|..:...|::::..
 Frog   603 LDGTLDVNRYCSTLIPL---LKIWTPLFKNYIKRASDHLCCLGAIEEFFLDNETLWAAIAKVLMA 664

  Fly   618 LYDKDFVSESAIQAWYAQLDEEEHA---HLRQSLAKLVAWLDQSSEEDDDEE 666
            .|.:|.::|..|..|::|.|..|..   ..:|.|.|.:.||:::.||..::|
 Frog   665 FYQQDVLAEEMILRWFSQTDVTEKGRQFRKKQVLQKFIQWLEEAEEESSEDE 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bepsilon	NP_569961.2	eIF-2B_epsilon_N	9..223	CDD:133040	75/221 (34%)
		LbetaH	326..397	CDD:469633	16/70 (23%)
		W2_eIF2B_epsilon	499..659	CDD:211396	55/168 (33%)
eif2b5	XP_002935185.3	eIF-2B_epsilon_N	39..253	CDD:133040	75/221 (34%)
		GlmU	<276..>409	CDD:440820	37/135 (27%)
		LbetaH	357..435	CDD:469633	19/77 (25%)
		W2_eIF2B_epsilon	543..706	CDD:211396	54/165 (33%)