DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbcn-3B and SKI8

DIOPT Version :9

Sequence 1:	NP_001284797.1	Gene:	Rbcn-3B / 31155	FlyBaseID:	FBgn0023510	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_011302.1	Gene:	SKI8 / 852659	SGDID:	S000003181	Length:	397	Species:	Saccharomyces cerevisiae

Alignment Length:	252	Identity:	48/252 - (19%)
Similarity:	78/252 - (30%)	Gaps:	92/252 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1240 RRAAIDLLGRGFTVWE--PYLDVSKVLLGLLEISCEGKAVPNLNY----------KLPLTPQADA 1292
            |..|.|:.|..: :|:  |:.|.|..|              .||:          :.|:||...|
Yeast   140 RLVATDVKGTTY-IWKFHPFADESNSL--------------TLNWSPTLELQGTVESPMTPSQFA 189

  Fly  1293 CRTARHALRLIATA--RPAAFITTMAREVARYNTMQQNAQSINTPLTQSVLHKAKGEILQ----- 1350
            .........||||.  .....|:.::.....||...|::...|:...:||....:|.:|.
Yeast   190 TSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDS 254

  Fly  1351 ----CVEMLIDKMQSEIAGLLVEVMDIALHCVDGNELKNRGLAELCPAICKFNQISHCAQTRRIA 1411
                |:.:...:....|..|.|.                                :|.:|
Yeast   255 NSFGCITLYETEFGERIGSLSVP--------------------------------THSSQ----- 282

  Fly  1412 VGANSGNLAIYELRQNKCQMIPAHTHPITSLAFSPDGKYLVSYSCAENRLSFWQTST 1468
              |:.|..              ||:..:.||:|:..|:.|.|... :.:|.||...|
Yeast   283 --ASLGEF--------------AHSSWVMSLSFNDSGETLCSAGW-DGKLRFWDVKT 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbcn-3B	NP_001284797.1	WD40	<11..>204	CDD:225201
		WD40 repeat	20..63	CDD:293791
		WD40	<22..202	CDD:295369
		WD40 repeat	68..107	CDD:293791
		WD40 repeat	118..152	CDD:293791
		WD40 repeat	160..204	CDD:293791
		WD40 repeat	212..251	CDD:293791
		WD40 repeat	406..459	CDD:293791
		WD40	<449..>607	CDD:225201
		WD40	453..>597	CDD:295369
		WD40 repeat	513..555	CDD:293791
		WD40 repeat	560..596	CDD:293791
		WD40	<1395..>1469	CDD:225201	16/74 (22%)
		WD40	<1399..1495	CDD:295369	16/70 (23%)
		WD40 repeat	1439..1466	CDD:293791	9/26 (35%)
SKI8	NP_011302.1	WD40	13..351	CDD:421866	48/252 (19%)
		WD40 repeat	19..60	CDD:293791
		WD40 repeat	66..119	CDD:293791
		WD40 repeat	124..180	CDD:293791	11/54 (20%)
		WD40 repeat	190..224	CDD:293791	7/33 (21%)
		WD40 repeat	236..275	CDD:293791	6/38 (16%)
		WD40 repeat	294..330	CDD:293791	10/30 (33%)
		WD40 repeat	357..391	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900