DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbcn-3B and AT4G11270

DIOPT Version :9

Sequence 1:	NP_001284797.1	Gene:	Rbcn-3B / 31155	FlyBaseID:	FBgn0023510	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001329550.1	Gene:	AT4G11270 / 826729	AraportID:	AT4G11270	Length:	1446	Species:	Arabidopsis thaliana

Alignment Length:	1764	Identity:	358/1764 - (20%)
Similarity:	587/1764 - (33%)	Gaps:	583/1764 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LWGPTAPTHCISSVFLSDDQFTLVTGCYDGQICLWQVEPTT----------LKMSPRCLLVGHSA 66
            ||....|:|.:::.....:..||.||..||.|..|.:..::          .::.|..:|.||::
plant     9 LWSRAPPSHRVTATASLTNPPTLYTGGSDGSIIWWSISSSSESNSVTRLPHHEIKPIAMLCGHTS 73

  Fly    67 PV--LCLVRASLLPENNF----------------LVSSSENGEMCTWDLTDGKCMEAVKLPQVHT 113
            |:  |.:...::|..|..                |:|:..:|.:|.|..:.|:|.:..|||....
plant    74 PIVDLAICDPTILSSNGVVASDNGNADPFVNCCALISACTDGVLCVWSRSSGQCRKRRKLPPWVG 138

  Fly   114 QIQSYHTANSEDVRLFCIGYYAEIMVMDPFSLEVIYVLSSKVKPDWISAIHVLRPMRRKDDVVLA 178
            ......|..||. |..|:|                   .|.:..|....:......:.:..||:.
plant   139 SPSILSTLPSEP-RYVCVG-------------------CSYIDVDGAETLADTDFQKSRCTVVVV 183

  Fly   179 ITTTGTVKVWTLTGNENKHAEPIYENESKEIRCLNAITMNCCAQNQRTVLLVCTKYWQI------ 237
            .|.|.|:......||             ..|.|||  .|.....:::..||:...:.::
plant   184 DTYTLTIVHTVFHGN-------------LSIGCLN--FMGVVQLDEQESLLMADSFGRLQLVSVS 233

  Fly   238 ---------------YDAGDFTVLCSVIAPARERWQGGD---FITSDRVMLW---TDEGKGYLYK 281
                           ...|:..|  |||.       .||   |.:..|.:.|   .:|..|.:
plant   234 EKSEPSKGSLVSRNWLSEGEIAV--SVIT-------RGDLVAFFSKSRCVFWLLNREEAIGEI-- 287

  Fly   282 LPANCIPDNKEFHSKS-VVRDAPYLYYVLQH-AGDKVLSCPPAMKLLQGAGGQHNLLRGDSEGYI 344
               :.:.|:   ||.: :.::|..||..... .|||..|......|..|:|..........:|..
plant   288 ---SFVDDS---HSSNFLFKEAMILYSSTSTIEGDKDDSISETFVLWDGSGSAVLFTMSYIDGEF 346

  Fly   345 SVWNVPEV---PLDNISI------LQAKQ------------MPPRPLKPHV-----C-------- 375
            :..|..|:   |.|..|:      :|.:|            ..|...:||:     |
plant   347 TYKNFGEIVTAPDDKRSVKSTFCFVQLRQNLLRVESSCCDVEQPSQWRPHITIWSLCLGNGKEKE 411

  Fly   376 --------TSLVEAW---SIMDPPP---------------------VGILDQLSRITESPVKLTS 408
                    :|....|   |.:||..                     ...:....:...|.:.::.
plant   412 LQRKVLGESSYFADWISSSCLDPKGSVSAETGTSQSGSQCSAKNDLQSFVSDNGQCVSSSMVISE 476

  Fly   409 SIYLPQQSRLVIGREDGSIVIVPATQTVMMQLLVGIKQNFSDWPS-------HQILYGHRGRVNC 466
            ::|:|.  .:|.|...|.|.|      .....|.||....|...|       .|.|.||.|.|.|
plant   477 NMYVPY--AVVYGFFSGEIEI------AKFDFLHGIDSPASSPRSDTDPLVYKQRLLGHTGSVLC 533

  Fly   467 LLCPSMI--HSRYEKSH-LLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPESCSPRILK 528
            |....|.  .:....|| |:||.:|..:.:|||.||:::.....|...:.|:::.|........|
plant   534 LAAHRMFGDANGCNSSHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAPTKRPWSK 598

  Fly   529 CICSVASDHSVTLVSLQERKCVTLASRHLFP-----VVTIKWRPLDDFLIVGC--------SD-- 578
            |..||..|..|.|.||:     ||....:||     ...:.|.....:  :.|        ||
plant   599 CFLSVGDDSCVALSSLE-----TLRVERMFPGHPNYPTKVVWDGTRGY--IACLFRSLSRKSDPI 656

  Fly   579 GSVYVWQMETGHLDRVLHGMLAEEVLS-ACDEQAEDGGSGGG-GGSNGASASEMGMANPAVHFFR 641
            ..:|:|.::||..:|||||..:..:.. .|...:|...||.. .|:...|:....:......|:
plant   657 DVLYIWDVKTGARERVLHGAASHSMFDHFCAGISEKSHSGTVLNGNTSVSSLLFPVDEERKPFY- 720

  Fly   642 GLKSRNMNAIRHATQRGITQLQQLQGHNQGNFDFLMKHRSNPLVIQGLR------TNPKDAESHI 700
             ||:.. .|...:|.:..:..::.:..:.....||          |.:|      |.|
plant   721 -LKNYE-RAASLSTSKPSSSQEKTREESSTASSFL----------QSIRYPSIKCTCP------- 766

  Fly   701 LFFDIEGLIFELHSEEYAQMTPATLESLGVHLQNPKDGKSMHLDASKKIGDFFNKVKNKAVDVEK 765
             |..|..|||:             |.||.|:.|..:|.                       |:.|
plant   767 -FPGISTLIFD-------------LSSLAVYCQTHEDS-----------------------DMHK 794

  Fly   766 ILKDK-DKHGLVQK-FKEKTEIVEKKVQAKVESLQKAVEPHEEQQDLKSKIASKMEVTHVMEVAQ 828
            :|::| ||....|| .|:|:.:            ||.::.|.|...:...|...:        .:
plant   795 MLEEKSDKATAQQKTSKDKSPV------------QKTLDNHAEVVHMDKAIGEYL--------IR 839

  Fly   829 LLLSLLHSWGLDPHLDKMCETRLGLLRPIVPISYGVLSKAGYMSLLLPTWQNNYAIPPGIQLPSS 893
            ..||.||.||:|..||:|....|.|.||                       .::.:..|:|....
plant   840 FSLSFLHLWGIDFELDQMLVAHLKLKRP-----------------------ESFIVTSGLQGDKG 881

  Fly   894 SKKRPLPEELQRLEHLTAVFTSRLHWELSTTLTTNHILALVAMSNTLLSMSAASFLPDSEKHKKL 958
            |.....|.....||          .|:.|:..|....:.:|:::..::|:|
plant   882 SLTLAFPGLNATLE----------LWKSSSEFTALRSVIMVSLAQCMISLS-------------- 922

  Fly   959 QRLAQRTDSTLSNEEEREELMAHHISQIKHAWSLLATHHCFLLPDKIEALEPKKFKRPQVEMMVK 1023
                 .:.:|.|                    |.||..:...|.:|...|:|     |.::::|.
plant   923 -----HSTATYS--------------------SNLAAFYTRNLAEKYPDLKP-----PLLQLLVT 957

  Fly  1024 RWQHHCIEIREAAQQILLGELTRMGKKGRKQLVESWAQYLPLYT-----HTEPIVGAQQQLALIS 1083
            .||.:..::|.||:.:.             ....|.|..|||.:     |.| :|.:...::| :
plant   958 FWQDNSEQVRMAARSLF-------------HHTASLAIPLPLCSDHASEHAE-LVRSLSGISL-N 1007

  Fly  1084 QPASGGAGSGSGGNGGVGVGVSGGGGAGSGSGPGGSVPGGDAHQDEDYEE-EEEEIIRKPSSLSE 1147
            :|.....|.                     ..|..|:.....||.:...: ||.||:   |.|..
plant  1008 EPKVLSTGE---------------------EYPTNSLDSEHIHQAQRLSQAEESEIL---SWLES 1048

  Fly  1148 LKRKQTTAVILLGVIGAEFGQDISQESPNHRGSISMATGANLTSGVAGGERRKSSVVEGFGIANN 1212
            .:.:.     .:..:|               |:...|..|::....|......|.|..|
plant  1049 FEMQD-----WISCVG---------------GTSQDAMAAHIIVAAALSIWYPSLVKPG------ 1087

  Fly  1213 LARLTSMALAHLLYAPPSPKLPQYTPLRRAAIDLLGRGF-TVWEPYL--DVSKVLLGL-LEISCE 1273
            ||.|....|.:|:.|...    :|:   ..|.:||..|. |.|:.::  |:.:::..: .:|.|.
plant  1088 LAMLVVHKLLNLVMAMSE----KYS---STAAELLSEGMETTWKTWIGPDIPRIVSDIFFQIECV 1145

  Fly  1274 G------KAVPN------LNYKLPLTPQAD---------------ACRTARHALRL-----IATA 1306
            .      :.||:      :...||....||               |..:..|.:.|     |..|
plant  1146 SSSVGAYQVVPSSIKETLVEVLLPSLAMADVLGFLSIIESQIWSTASDSPVHVVSLRTLIRIIRA 1210

  Fly  1307 RPAAFITTMAREVARYNTMQQNAQSINTPLTQSVLHKAKG---EILQCVEMLI---DKMQSEIAG 1365
            .|...:..:.:.|   |.:.|.....||.:.::.|..:..   |:::...|:|   ...:..|..
plant  1211 APRNLVLHLEKAV---NFVLQTMDPSNTVMRKTCLQTSMATLREVVRVFPMVILNDSSTRLAIGD 1272

  Fly  1366 LLVEVMDIALHCVDGNEL-KNRGL-AELCPAICKFNQISHCAQTRRIAVGANSGNLAIYELRQNK 1428
            ::.|:.:..:|..|...: |.|.| |...|.:..|.:            ||:..
plant  1273 VITEINNACIHIYDMRSMTKIRVLDASGPPGLPNFLR------------GASES----------- 1314

  Fly  1429 CQMIPAHTHPITSLAFSPDGKYLVSYSCAENRLSFWQTSTGMF---GLGQSQT--RCTK------ 1482
                 |.|..|::|:|||||:.||::|  ||.|.....|.|..   .|.||.|  :|||
plant  1315 -----AVTTAISALSFSPDGEGLVAFS--ENGLMIRWWSLGSVWWEKLSQSLTPIQCTKLIFIHP 1372

  Fly  1483 --GYSTA-----------------PIPDVSR--LNPMRLAKLV----------WINNRTVTLMLA 1516
              |:|::                 |:.:.::  .:..||.:||          |.:.|.|.|
plant  1373 WDGFSSSSSRTSVISSISNDEQELPLQETAKNISHVERLKQLVQHLDLSYRLEWASERKVVL--- 1434

  Fly  1517 DGSETRFNV 1525
                ||.||
plant  1435 ----TRHNV 1439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbcn-3B	NP_001284797.1	WD40	<11..>204	CDD:225201	45/219 (21%)
		WD40 repeat	20..63	CDD:293791	11/52 (21%)
		WD40	<22..202	CDD:295369	41/207 (20%)
		WD40 repeat	68..107	CDD:293791	10/56 (18%)
		WD40 repeat	118..152	CDD:293791	6/33 (18%)
		WD40 repeat	160..204	CDD:293791	7/43 (16%)
		WD40 repeat	212..251	CDD:293791	9/59 (15%)
		WD40 repeat	406..459	CDD:293791	14/59 (24%)
		WD40	<449..>607	CDD:225201	51/183 (28%)
		WD40	453..>597	CDD:295369	48/168 (29%)
		WD40 repeat	513..555	CDD:293791	13/41 (32%)
		WD40 repeat	560..596	CDD:293791	10/45 (22%)
		WD40	<1395..>1469	CDD:225201	19/73 (26%)
		WD40	<1399..1495	CDD:295369	29/127 (23%)
		WD40 repeat	1439..1466	CDD:293791	13/26 (50%)
AT4G11270	NP_001329550.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I1994
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D84170at2759
OrthoFinder	1	1.000	-	-		FOG0002541
OrthoInspector	1	1.000	-	-		oto3122
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR44099
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060