DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbcn-3B and TEP1

DIOPT Version :9

Sequence 1:	NP_001284797.1	Gene:	Rbcn-3B / 31155	FlyBaseID:	FBgn0023510	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_009041.2	Gene:	TEP1 / 7011	HGNCID:	11726	Length:	2627	Species:	Homo sapiens

Alignment Length:	918	Identity:	169/918 - (18%)
Similarity:	262/918 - (28%)	Gaps:	362/918 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VFLSDDQFTLVTGCYDGQICLWQVEPTTLKMSPRCLLVGHSAPVLCLVRASLLPENNFLVSSSEN 89
            :|||||  ||....:||.:.||.::       ..|.::...|....:....|.|:...|.:....
Human  1725 LFLSDD--TLFLTAFDGLLELWDLQ-------HGCRVLQTKAHQYQITGCCLSPDCRLLATVCLG 1780

  Fly    90 GEMCTWDLTDGKCMEAVKLPQVHTQIQSYHTANSEDVRLFCIGYYAEIMVMD----PFSLEVIYV 150
            |.:..||...|      :|...||..:|          |.|:.::.|..|:.    ..|:....|
Human  1781 GCLKLWDTVRG------QLAFQHTYPKS----------LNCVAFHPEGQVIATGSWAGSISFFQV 1829

  Fly   151 LSSKVKPDWISAIHVLRPMRRKDDVVLAITTTG----------TVKVWTLTGNENKHAEPIYENE 205
            ...||..|..:....:|        .||....|          .|::|.........|.|.:...
Human  1830 DGLKVTKDLGAPGASIR--------TLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGF 1886

  Fly   206 SKEIRCLNAITMNCCAQNQRTVLLVCTKYWQIYDAGDFTVLCSVIAPARERWQGGDFITSDRVML 270
            ......|:|   .|                |:..||:                      ..:|.:
Human  1887 VAAALFLHA---GC----------------QLLTAGE----------------------DGKVQV 1910

  Fly   271 WT---DEGKGYLYKLPANCIPDNKEFHSKSVVRDAPYLYYVLQHAGDKV--------LSCPPAMK 324
            |:   ...:|:|..|..                 :|.|...|...||:|        :.......
Human  1911 WSGSLGRPRGHLGSLSL-----------------SPALSVALSPDGDRVAVGYRADGIRIYKISS 1958

  Fly   325 LLQGAGGQ--------------HNLLRGDSEGYISVWNVPEVPLDNISILQAKQMPPRPLKPHVC 375
            ..|||.||              ..|:.|..:|.:..|.:.|..|.::
Human  1959 GSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSL------------------ 2005

  Fly   376 TSLVEAWSIMDPPPVGILDQLSRITESPVKLTSSIYLPQQSRLVIGREDGSIVIVPATQTVMMQL 440
                  |            .|||..:..:.|.:|     |..|....||.::.:.|      .||
Human  2006 ------W------------LLSRFQKPVLGLATS-----QELLASASEDFTVQLWP------RQL 2041

  Fly   441 LVGIKQNFSDWPSHQILYGHRGRVNC------------------LLC--------PSMIHS---- 475
            |.. .....|:|....|.||.|.|:|                  |||        |.:|||
Human  2042 LTR-PHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPAC 2105

  Fly   476 --------RYEKSHLL-SGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLL--------------- 516
                    .:.|.:|| |...|.:|.|||..||..|.:|..|...::.:.
Human  2106 HRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTL 2170

  Fly   517 ------------VPPES-----CS----PR-------------------------ILKC------ 529
                        :|..|     |:    ||                         :|.|
Human  2171 KVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLL 2235

  Fly   530 -----------------ICSVASDHSVTLVSLQERKCVTLASRHLFPVVTIKWRPLDDFLIVGCS 577
                             :.:.:.|.||.|..:.:....|...|....|..:.|.|.....:.|..
Human  2236 GHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQ 2300

  Fly   578 DGSVYVWQ--------METGHLDRVLHG-------MLAEEVLSACDEQAEDGGSGGGGGSNGASA 627
            .|.:.:||        ...||:..::..       :.|:|.:|....:...|.:.|
Human  2301 AGELILWQEAKAVATAQAPGHIGALIWSSAHTFFVLSADEKISEWQVKLRKGSAPG--------- 2356

  Fly   628 SEMGMANPAVHFFRGLKSRNMNAIRHATQRGITQLQQLQGHNQGNFDFLMKHRSNPLVIQGLRTN 692
                  |.::|..|.|            |..:..|..|.....|:|..|.|.....|.::
Human  2357 ------NLSLHLNRIL------------QEDLGVLTSLDWAPDGHFLILAKADLKLLCMK----- 2398

  Fly   693 PKDAESHILFFDIEG-LIFELHSEEYAQMTPATLESLGVHLQNPKDGKSMHLDASKKIGDFFNKV 756
            |.||.|.|.....|. :|...|.|            .|:.:..|||...:.....|:.|:|..::
Human  2399 PGDAPSEIWSSYTENPMILSTHKE------------YGIFVLQPKDPGVLSFLRQKESGEFEERL 2451

  Fly   757 KNKAVDVE 764
             |..:::|
Human  2452 -NFDINLE 2458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbcn-3B	NP_001284797.1	WD40	<11..>204	CDD:225201	41/192 (21%)
		WD40 repeat	20..63	CDD:293791	12/37 (32%)
		WD40	<22..202	CDD:295369	41/190 (22%)
		WD40 repeat	68..107	CDD:293791	7/38 (18%)
		WD40 repeat	118..152	CDD:293791	6/37 (16%)
		WD40 repeat	160..204	CDD:293791	8/53 (15%)
		WD40 repeat	212..251	CDD:293791	6/38 (16%)
		WD40 repeat	406..459	CDD:293791	13/52 (25%)
		WD40	<449..>607	CDD:225201	54/295 (18%)
		WD40	453..>597	CDD:295369	49/274 (18%)
		WD40 repeat	513..555	CDD:293791	12/125 (10%)
		WD40 repeat	560..596	CDD:293791	9/43 (21%)
		WD40	<1395..>1469	CDD:225201
		WD40	<1399..1495	CDD:295369
		WD40 repeat	1439..1466	CDD:293791
TEP1	NP_009041.2	TEP1 N-terminal 1	1..30
		TEP1_N	1..29	CDD:283129
		TEP1 N-terminal 2	31..60
		TEP1_N	31..59	CDD:283129
		TEP1 N-terminal 3	61..90
		TEP1_N	61..89	CDD:283129
		TEP1 N-terminal 4	91..120
		TEP1_N	91..119	CDD:283129
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..214
		TROVE	226..676	CDD:283406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..402
		DUF4062	908..1008	CDD:290011
		NACHT	1162..1337	CDD:283404
		WD 1	1411..1448
		WD 2	1674..1713
		WD40	1680..1955	CDD:295369	58/320 (18%)
		WD40	<1680..1824	CDD:225201	28/123 (23%)
		WD40 repeat	1680..1716	CDD:293791
		WD 3	1716..1754		12/37 (32%)
		WD40 repeat	1722..1757	CDD:293791	12/40 (30%)
		WD 4	1757..1796		9/44 (20%)
		WD40 repeat	1762..1801	CDD:293791	10/44 (23%)
		WD 5	1798..1837		10/48 (21%)
		WD40	1799..2190	CDD:225201	91/514 (18%)
		WD40 repeat	1804..1840	CDD:293791	8/35 (23%)
		WD 6	1840..1879		6/46 (13%)
		WD40 repeat	1845..1881	CDD:293791	7/43 (16%)
		WD 7	1882..1921		8/79 (10%)
		WD40 repeat	1888..1923	CDD:293791	9/75 (12%)
		WD 8	1925..1964		9/55 (16%)
		WD 9	1967..2005		6/37 (16%)
		WD40	1972..2308	CDD:238121	67/383 (17%)
		WD40 repeat	1972..2013	CDD:293791	10/76 (13%)
		WD 10	2008..2047		13/50 (26%)
		WD40 repeat	2016..2059	CDD:293791	13/54 (24%)
		WD40	2022..2391	CDD:225201	75/402 (19%)
		WD 11	2059..2098		9/38 (24%)
		WD40 repeat	2064..2103	CDD:293791	9/38 (24%)
		WD 12	2105..2143		12/37 (32%)
		WD40 repeat	2111..2145	CDD:293791	12/33 (36%)
		WD 13	2146..2183		1/36 (3%)
		WD40 repeat	2151..2235	CDD:293791	7/83 (8%)
		WD 14	2185..2233		6/47 (13%)
		WD40	2231..>2391	CDD:295369	31/186 (17%)
		WD 15	2236..2275		4/38 (11%)
		WD40 repeat	2241..2280	CDD:293791	6/38 (16%)
		WD 16	2278..2317		8/38 (21%)
		WD40 repeat	2283..2307	CDD:293791	5/23 (22%)
		WD 17	2319..2355		6/35 (17%)
		WD40 repeat	2326..2359	CDD:293791	6/47 (13%)
		WD 18	2368..2417		13/53 (25%)
		WD40 repeat	2372..2418	CDD:293791	14/50 (28%)
		WD 19	2459..2500		169/918 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2506..2551
		WD 20	2553..2590
		WD 21	2592..2626
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900