DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbcn-3B and wdr7

DIOPT Version :9

Sequence 1:	NP_001284797.1	Gene:	Rbcn-3B / 31155	FlyBaseID:	FBgn0023510	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_017208486.1	Gene:	wdr7 / 572502	-ID:	-	Length:	1470	Species:	Danio rerio

Alignment Length:	1598	Identity:	650/1598 - (40%)
Similarity:	952/1598 - (59%)	Gaps:	201/1598 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVSTNLVVPVVLWGPTAPTHCISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLKMSPRCLLVGHS 65
            |...:||:|:|||...||||||||:.:.:|..|::||.:|||||:|.:.| .|:::||.||.||:
Zfish     1 MSGNSLVLPIVLWSRNAPTHCISSLLVMEDLATIITGSHDGQICIWDMTP-ELEINPRALLFGHT 64

  Fly    66 APVLCLVRASLLPENNFLVSSSENGEMCTWDLTDGKCMEAVKLPQVHTQIQSYH--TANSEDVRL 128
            |.|.||.:||...|..:|||:||:||||.||:.||:|:|..||...||.||.|.  .....:.||
Zfish    65 ASVTCLSKASAGSEKQYLVSASESGEMCLWDVNDGRCIEFTKLACAHTGIQFYQFTIGTQREGRL 129

  Fly   129 FCIGYYAEIMVMDPFSLEVIYVLSSKVKPDWISAIHVLRPMRRKDDVVLAITTTGTVKVWTLTGN 193
            .|.|:|.||:|||..||||:|.|.||:.|||||::.::|..|.::|.|:|::.||.:|||.:|.:
Zfish   130 LCHGHYPEILVMDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVAVSVTGILKVWIITAD 194

  Fly   194 ENK--HAEPIYENESKEIRCLNAITMNCCAQNQRTVLLVCTKYWQIYDAGDFTVLCSVIAPARER 256
            .::  ..:|::|.|||.|.|....:::.|...|.::|:||:|||:::|||||::||||.:...:.
Zfish   195 VSRMQDLDPVFEEESKPIYCQGCQSISFCTFTQLSLLVVCSKYWRVFDAGDFSLLCSVSSENNQS 259

  Fly   257 WQGGDFITSDRVMLWTDEGKGYLYKLPANCIPDNKEFHS----KSVVRDAPYLYYVLQHAGDKVL 317
            |.||:||.:|:|::||::|..|:|||||:|:|.::.|.|    ||.....|.:|.:...|..::|
Zfish   260 WAGGEFIAADKVIIWTEDGCSYIYKLPASCLPASEHFRSNVGKKSEGSIPPLVYSIADQADKQLL 324

  Fly   318 SCPPAMKLLQGAGGQ-HNLL-RGDSEGYISVWNVPEV--PLDNISILQAKQMPPRPLKPHVCTSL 378
            .|||..:...|.... |.|| :|||.|.::||::|:.  |:..::       ....|:..|..||
Zfish   325 ICPPVTRFFFGRREPFHKLLMQGDSAGRLTVWSIPDASPPIQQLT-------SATELQVSVSISL 382

  Fly   379 VEAWSIMDPPPVGILDQLSRI--TESPVKLTSSIYLPQQSRLVIGREDGSIVIVPATQTVMMQLL 441
            .||:..:.|.|.||:||||.:  ...|:|:|:|:|:|.|.|||.|||||||::||||||.::|||
Zfish   383 QEAFDKLLPAPAGIIDQLSVLPGASEPIKVTASVYIPSQGRLVCGREDGSIILVPATQTAIVQLL 447

  Fly   442 VGIKQNFSDWPSHQILYGHRGRVNCLLCPSMIHSRYEKSHLLSGGIDFAVCLWDLYSGSLLHRFC 506
            .|.......||.|:.|.|||.:|.|||.|..:..||::..|:|||:||:|.:||:::|.:.|.||
Zfish   448 QGEHMLRRGWPPHRTLRGHRHKVTCLLYPHQVSPRYDQRSLVSGGVDFSVIIWDIFTGEMKHIFC 512

  Fly   507 VHAGEITQLLVPPESCSPRILKCICSVASDHSVTLVSLQERKCVTLASRHLFPVVTIKWRPLDDF 571
            ||.||||||:||||:||.|:..|:|||||||||.|:||:||||:.||||||||:..|||||.||:
Zfish   513 VHGGEITQLIVPPENCSTRVQHCVCSVASDHSVGLLSLRERKCIMLASRHLFPIQVIKWRPCDDY 577

  Fly   572 LIVGCSDGSVYVWQMETGHLDRVLHGMLAEEVLSACDEQAEDGGSGGGGGSNGASASEMGMANPA 636
            |:|||||||||||||:||.|||.:.|:.|.|:|:||||.              ..|:...:.:||
Zfish   578 LVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEV--------------VPAALDSLNHPA 628

  Fly   637 VHFFRGLKSRNMNAIR----HATQRGITQLQQLQGHNQGNFDFLMKHRSNPLVIQGLRTNPKDAE 697
            |:..:.:..|::.|::    |..|...|.|......::||   |.|:..|.||:|.::||..|.:
Zfish   629 VNLKQAMTRRSLAALKNMAQHKLQTLATNLLAADNADKGN---LPKYSHNSLVVQAMKTNMTDPD 690

  Fly   698 SHILFFDIEGLIFELHSEEYAQMTPATLESLGVHLQNPKDGKSMHLDASKKIGDFF-NKVKNKAV 761
            .|:||||:|.:|.:|.:|| ||....||.|... ||....|       :.|.|.|. ||:
Zfish   691 MHVLFFDVEAVIIQLLTEE-AQRPNPTLVSPET-LQKTPGG-------ADKGGSFLANKI----- 741

  Fly   762 DVEKILKDKDKHGLVQKFKEKTEIVEKKVQAKVESLQKAVEPHEEQQ---DLKSKIASKMEVTHV 823
                             ||:..|.:::.::   |.|....|..||:|   :.|||..|.:|....
Zfish   742 -----------------FKQVKETIKENIK---EHLLDEDEDEEEEQRRREEKSKSLSLLEYNLT 786

  Fly   824 MEVAQLLLSLLHSWGLDPHLDKMCETRLGLLRPIVPISYGVLSKAGYMSLLLPTWQNN----YAI 884
            |:.|:|.:|.||:|||:..||::|.:|||:|||..|||:|::|:.|:|||:|||::::    .|:
Zfish   787 MDTAKLFMSCLHAWGLNAELDEVCVSRLGMLRPHTPISFGLISRGGHMSLMLPTFKDSLLRALAL 851

  Fly   885 PPGIQLPSSSKKRPLPEELQRLEHLTAVFTSRLHWELSTTLTTNHILALVAMSNTLLSMSAASFL 949
            ..|   ....:|..:.|           ...:..:.:|..:||.|:|::::::|||:.|:.|:|:
Zfish   852 AQG---AVEGRKLSVSE-----------VVGKGTYGVSRAVTTQHLLSVISLANTLMGMTNATFI 902

  Fly   950 PDSEKH----------KKLQRLAQRTDSTLSNEEEREELMA---------HHISQIKHAWSLLAT 995
            .:..|.          .:.||.:....|:.:.:.:.::..|         .|...:...||.||.
Zfish   903 GEHMKKAPARPPRPGTPETQRKSSTQTSSPALQGQIKQAAAAAPSSASGVFHSPSVNEGWSQLAA 967

  Fly   996 HHCFLLPDKIEALEPKKFKRPQVEMMVKRWQHHCIEIREAAQQILLGELTRMGKKGRKQLVESWA 1060
            .||.:|||   .|...||:.|.:||:.:|||..|:|:|||||.:||.||.|:|:.|||..::.||
Zfish   968 MHCVMLPD---LLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRVGQSGRKDTIDLWA 1029

  Fly  1061 QYLPLYTHTEPIVGAQQQLALISQPASGGAGSGSGGNGGVGVGVSGGGGAGSGSGPGGSVPGGDA 1125
            .|||.|..|....|...:.|....|                              |..:.|....
Zfish  1030 PYLPQYVDTVSSPGTAPETAPQVPP------------------------------PAEAPPTETK 1064

  Fly  1126 HQDEDYEEEEEEI-----------IRKPSSLSELKRKQTTAVILLGVIGAEFGQDISQESPNHRG 1179
            ..:|:.:..:::|           .:|..:..|.:|||.||::||||||||||.:|  |.|.
Zfish  1065 VPEEEMDVTDDDITAGCLSNLPPNTKKICNSYEERRKQATAIVLLGVIGAEFGAEI--EPPK--- 1124

  Fly  1180 SISMATGANLTSGVAGGERRKSSVVEGFGIAN-----NLARLTSMALAHLLYAPPSPKLPQYTPL 1239
                         :....|..:...:|||::.     :|||.|..||..||..|||||||.::.:
Zfish  1125 -------------LPSRARTSTQAPDGFGLSTGGANYSLARHTCKALTFLLLQPPSPKLPPHSTI 1176

  Fly  1240 RRAAIDLLGRGFTVWEPYLDVSKVLLGLLEISCEG-KAVPNLNYKLPLTPQADACRTARHALRLI 1303
            ||.||||:||||||||||:|||.||:||||:..:. |.:.|::..|||:|.||:.|:|||||.||
Zfish  1177 RRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLSNISMGLPLSPAADSARSARHALSLI 1241

  Fly  1304 ATARPAAFITTMAREVARYNTMQ----QNAQSINTPLTQSVLHKAKGEILQCVEMLIDKMQSEIA 1364
            |||||.|||||:||||.|:..||    |:.|:|:|    :.|.:||.|||:.:|:||:||.|::.
Zfish  1242 ATARPPAFITTIAREVHRHTAMQSQGSQSQQNIHT----TTLARAKTEILRVIEILIEKMPSDVV 1302

  Fly  1365 GLLVEVMDIALHCVDGNELKNRGLAELCPAICKFNQISHCAQTRRIAVGANSGNLAIYELRQNKC 1429
            .||||||||.::|::|:.:|.:||:|..||||:|..:::|.::.||||||..|::|:|::|..||
Zfish  1303 DLLVEVMDIIMYCIEGSLVKKKGLSECFPAICRFYMVAYCERSYRIAVGARQGSVALYDVRTGKC 1367

  Fly  1430 QMIPAHTHPITSLAFSPDGKYLVSYSCAENRLSFWQTSTGMFG-LGQ----SQTRCTKGYSTAPI 1489
            |.|..|..|||:::|:|||:||.:||.|::.:||||.:|.:.| :|.    .|.||.|.|...|:
Zfish  1368 QHIHGHKGPITAVSFAPDGRYLATYSNADSHISFWQMNTSLLGSIGMLNSAPQLRCIKTYQVPPV 1432

  Fly  1490 PDVS--RLNPMRLAKLVWINNRTVTLMLADGSETRFNV 1525
            ...|  ..|.::||:|:|.:||.|.||..||.|.||.|
Zfish  1433 QPASPGSQNALKLARLIWTSNRNVILMAHDGKEHRFMV 1470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbcn-3B	NP_001284797.1	WD40	<11..>204	CDD:225201	93/196 (47%)
		WD40 repeat	20..63	CDD:293791	21/42 (50%)
		WD40	<22..202	CDD:295369	85/183 (46%)
		WD40 repeat	68..107	CDD:293791	21/38 (55%)
		WD40 repeat	118..152	CDD:293791	16/35 (46%)
		WD40 repeat	160..204	CDD:293791	14/45 (31%)
		WD40 repeat	212..251	CDD:293791	17/38 (45%)
		WD40 repeat	406..459	CDD:293791	29/52 (56%)
		WD40	<449..>607	CDD:225201	97/157 (62%)
		WD40	453..>597	CDD:295369	91/143 (64%)
		WD40 repeat	513..555	CDD:293791	29/41 (71%)
		WD40 repeat	560..596	CDD:293791	26/35 (74%)
		WD40	<1395..>1469	CDD:225201	35/73 (48%)
		WD40	<1399..1495	CDD:295369	42/102 (41%)
		WD40 repeat	1439..1466	CDD:293791	14/26 (54%)
wdr7	XP_017208486.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579343
Domainoid	1	1.000	347	1.000	Domainoid score	I1004
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11408
Inparanoid	1	1.050	803	1.000	Inparanoid score	I473
OMA	1	1.010	-	-		QHG55878
OrthoDB	1	1.010	-	-		D331603at33208
OrthoFinder	1	1.000	-	-		FOG0002541
OrthoInspector	1	1.000	-	-		oto41780
orthoMCL	1	0.900	-	-		OOG6_104321
Panther	1	1.100	-	-	LDO	PTHR44099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4954
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910