DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbcn-3B and rig

DIOPT Version :9

Sequence 1:	NP_001284797.1	Gene:	Rbcn-3B / 31155	FlyBaseID:	FBgn0023510	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_611499.3	Gene:	rig / 37335	FlyBaseID:	FBgn0250850	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	844	Identity:	164/844 - (19%)
Similarity:	257/844 - (30%)	Gaps:	314/844 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 SLVEAWSIMDPPPVGILDQ------LSRITES-----PVKLTSSIYL----PQQSRLVIGREDGS 426
            ::.|....|:...:|..|:      :|::|.|     .|.::|::|.    |....|..|..||:
  Fly   572 AMAECPDDMNKIALGCSDRRVAFFDISKLTTSCLPIDSVYVSSNVYCLAWSPNCLELAFGTFDGT 636

  Fly   427 IVIVPATQ-TVMMQLLVGIKQNFSD--WPSHQILYGHRGR----------------VNCLLCPSM 472
            :.|:...: .|...|....|:....  |..| .:|....|                |||:..||.
  Fly   637 VGILDVERMKVKTHLRTPHKKEVYSLVWQDH-FIYFIVNRVLGFFDLRKSKIEPTIVNCISRPSY 700

  Fly   473 IHSRYEKSHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPESCSPRILKCICSVASDH 537
            :..|  .|.|..|..|..:.:.:..||.                  .:|.||.|.:.
  Fly   701 LSIR--DSFLFVGTDDGLLQIHERDSGM------------------EKSWSPFIRQS-------- 737

  Fly   538 SVTLVSLQERKCVTLASRHLFPVVTIKWRPLDD--FLIVGCSDGSVYVWQME-TGHLDRVLHGML 599
                         .|.:|:   |..|.|.|||.  |.:.| :|.||||.:.: |....:.||...
  Fly   738 -------------ALFARY---VTDIAWCPLDSNKFAVSG-NDRSVYVMEFQPTERNWKTLHTFT 785

  Fly   600 AEEVLSACDEQAEDGGSGGGGGSNGASASEMGMANPAVHFFRGLKSRNMNAIRHATQRGITQLQQ 664
            |                      |...||                              ||.::
  Fly   786 A----------------------NTEKAS------------------------------ITSMR- 797

  Fly   665 LQGHNQGNFDFLMKHRSNPLVIQGLRTNPKDAESHILFFDIEG--------------LIFELHSE 715
             ..|.|       ||.                   :|.|.|||              |....|..
  Fly   798 -WSHTQ-------KHL-------------------LLTFHIEGKVCLWNCNAPEKPPLTITYHCP 835

  Fly   716 EYAQMTPATLE--------SLGVHLQNPKDG-----KSM--HLD-------ASKKIGDFFNKV-- 756
            .:..|...|.|        :|.|.|.:.||.     ||:  .:|       |||.:...:..|
  Fly   836 MWCGMFLPTNENIIMCSGKALSVELIDIKDALEGDEKSICPKVDALLNVKWASKSLTQPYAPVLT 900

  Fly   757 -----------KNKAVDVEKILKDKDKHGLVQKFKEK-TEIVEKKVQAK------VESLQKAVEP 803
                       :..|..:|..:.:||:    :|.:|. |.:::.....|      ||.:.:|:..
  Fly   901 AAEKKRQRRDQRKAAAKLEVDVANKDQ----KKIQESVTAVIDNPTNDKCTQETPVEEMLEALSL 961

  Fly   804 HEEQQDLKSKIASKMEVTHVMEVAQLLLSLLHSWGLDPHLDKMCETRLGLLRPIVPISYGVLSKA 868
            .:||.:..:|...|.:       .|...|..||                  |..:.::...|:|:
  Fly   962 DKEQNNRSAKECPKCK-------EQSPDSFTHS------------------RTCLYLTQKELNKS 1001

  Fly   869 GYMSLLLPTWQNNYAIPPGIQLPS--SSK---KRPLPEELQRLEH---------LTAVFTSRLHW 919
            ....|.:...:::..|...:.:..  |||   |..:..||..|:|         ..|:.|.:|..
  Fly  1002 ALEKLAIVLTEDSAKIDKSVLISKLFSSKVMAKELIATELTNLKHSNTKDIAPLCLAMSTFKLRE 1066

  Fly   920 EL-----STTLTTNHILALVAMSNTLLSMSAASFLPDSEK-----HKKLQRLAQRTDST-----L 969
            ||     :.|||..|:....::|.||......::....|:     |......:|...|.     |
  Fly  1067 ELEQHIANKTLTERHVSLAPSVSFTLWQDCCRAYAKQMEEKGYIMHAATYLFSQGMQSEAIKLFL 1131

  Fly   970 SNEEEREELMAHHISQIKHAWSLLATHHCFLLPDKIEALEPKKFKRPQVEMMVKRWQHHCIEIRE 1034
            :||..:|.|:...|              |....|            |.::.::..|..|......
  Fly  1132 ANEYYKEALVHARI--------------CLPATD------------PLIKTVINNWLEHLEGTGN 1170

  Fly  1035 AAQQILLGELTRMGKKGRKQLVESWAQYLPLYTHTEP-IVGAQQQLALISQPASGGAGSGSGGN 1097
            .|...|:..|.....:|        ..||..|.:..| |.....|:..|.|  .||...|...|
  Fly  1171 FAAAALICVLDNEMLRG--------YSYLRKYRNCTPEIADLMDQIKRIGQ--LGGVLDGCAPN 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbcn-3B	NP_001284797.1	WD40	<11..>204	CDD:225201
		WD40 repeat	20..63	CDD:293791
		WD40	<22..202	CDD:295369
		WD40 repeat	68..107	CDD:293791
		WD40 repeat	118..152	CDD:293791
		WD40 repeat	160..204	CDD:293791
		WD40 repeat	212..251	CDD:293791
		WD40 repeat	406..459	CDD:293791	13/59 (22%)
		WD40	<449..>607	CDD:225201	39/178 (22%)
		WD40	453..>597	CDD:295369	36/162 (22%)
		WD40 repeat	513..555	CDD:293791	5/41 (12%)
		WD40 repeat	560..596	CDD:293791	14/38 (37%)
		WD40	<1395..>1469	CDD:225201
		WD40	<1399..1495	CDD:295369
		WD40 repeat	1439..1466	CDD:293791
rig	NP_611499.3	WD40	<80..>215	CDD:295369
		WD40	80..>215	CDD:225201
		WD40 repeat	116..160	CDD:293791
		WD40 repeat	167..204	CDD:293791
		WD40	434..821	CDD:225201	72/374 (19%)
		WD40	446..719	CDD:295369	33/149 (22%)
		WD40	613..874	CDD:295369	75/386 (19%)
		WD40 repeat	617..654	CDD:293791	9/36 (25%)
		WD40 repeat	659..691	CDD:293791	4/32 (13%)
		WD40 repeat	693..732	CDD:293791	12/58 (21%)
		WD40 repeat	744..785	CDD:293791	16/41 (39%)
		WD40 repeat	793..831	CDD:293791	12/65 (18%)
		WD40 repeat	838..861	CDD:293791	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900