DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbcn-3B and Wdr61

DIOPT Version :9

Sequence 1:	NP_001284797.1	Gene:	Rbcn-3B / 31155	FlyBaseID:	FBgn0023510	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001020914.1	Gene:	Wdr61 / 363064	RGDID:	1308228	Length:	305	Species:	Rattus norvegicus

Alignment Length:	286	Identity:	62/286 - (21%)
Similarity:	101/286 - (35%)	Gaps:	60/286 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 LRGDSEGYISVWNVPEVPLDNISILQAKQMPPRPLKPHVCTSLVEAWSIMDPPPVGILDQLSRIT 400
            |.|...|.:||.....:|:...|.|.|.               :..|.:.:.      .|:..|.
  Rat    60 LEGHQLGVVSVDISHTLPIAASSSLDAH---------------IRLWDLENG------KQMKSID 103

  Fly   401 ESPVKLTSSIYLPQQSRLVIGREDGSIVIVPATQTVMMQLLVGIKQNFSDWPSHQILYGHRGRVN 465
            ..||...:..:.|....|..|...|.:.|.....        |.|:...|.....||
  Rat   104 AGPVDAWTLAFSPDSQHLATGTHMGKVNIFGVES--------GKKEYSLDTRGKFIL-------- 152

  Fly   466 CLLCPSMIHSRYEKSHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPESCSPRILKCI 530
                 |:.:|. :..:|.||.||..:.::|:.:|.|||....||..|..|...|:|      :.:
  Rat   153 -----SIAYSP-DGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDS------QLL 205

  Fly   531 CSVASDHSVTLVSLQERKCVTLASRHLFPVVTIKWRPLDDFLIVGCSDGSVYVWQMET------- 588
            .:.:.|..:.:..:|........|.|...|:.:.:.|.|...:...||.||.||.:.|
  Rat   206 VTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCIHTF 270

  Fly   589 -GHLDR---VLHGMLAEEVLSACDEQ 610
             .|.|:   |.:.....:::|..|:|
  Rat   271 FDHQDQVWGVKYNGNGSKIVSVGDDQ 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbcn-3B	NP_001284797.1	WD40	<11..>204	CDD:225201
		WD40 repeat	20..63	CDD:293791
		WD40	<22..202	CDD:295369
		WD40 repeat	68..107	CDD:293791
		WD40 repeat	118..152	CDD:293791
		WD40 repeat	160..204	CDD:293791
		WD40 repeat	212..251	CDD:293791
		WD40 repeat	406..459	CDD:293791	10/52 (19%)
		WD40	<449..>607	CDD:225201	39/168 (23%)
		WD40	453..>597	CDD:295369	37/154 (24%)
		WD40 repeat	513..555	CDD:293791	5/41 (12%)
		WD40 repeat	560..596	CDD:293791	13/46 (28%)
		WD40	<1395..>1469	CDD:225201
		WD40	<1399..1495	CDD:295369
		WD40 repeat	1439..1466	CDD:293791
Wdr61	NP_001020914.1	WD40	13..302	CDD:238121	62/286 (22%)
		WD 1	14..57
		WD40 repeat	19..62	CDD:293791	1/1 (100%)
		WD 2	62..101		10/59 (17%)
		WD40 repeat	68..105	CDD:293791	9/57 (16%)
		WD 3	104..143		9/46 (20%)
		WD40 repeat	110..146	CDD:293791	7/43 (16%)
		WD 4	146..187		14/54 (26%)
		WD40 repeat	152..188	CDD:293791	13/49 (27%)
		WD 5	188..227		8/44 (18%)
		WD40 repeat	193..229	CDD:293791	6/41 (15%)
		WD 6	230..269		11/38 (29%)
		WD40 repeat	236..271	CDD:293791	9/34 (26%)
		WD 7	272..305		6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900