DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbcn-3B and APAF1

DIOPT Version :9

Sequence 1:	NP_001284797.1	Gene:	Rbcn-3B / 31155	FlyBaseID:	FBgn0023510	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_863651.1	Gene:	APAF1 / 317	HGNCID:	576	Length:	1248	Species:	Homo sapiens

Alignment Length:	648	Identity:	114/648 - (17%)
Similarity:	198/648 - (30%)	Gaps:	234/648 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SDDQFTLVTGCYDGQICLWQVEPTTLKMSPRCLLVGHSAPVLCLVRASLLPENNFLVSSSENGEM 92
            |.....|.||..|..:.||.:.    :...|..:.||:..|   ......|::..|.|.|.:|.:
Human   710 SSHHLLLATGSSDCFLKLWDLN----QKECRNTMFGHTNSV---NHCRFSPDDKLLASCSADGTL 767

  Fly    93 CTWDLTDGKCMEAVKLPQVHTQIQSYHTANSEDVRLF--CIGYYAEIMVMDPFSLEVIYVLSSKV 155
            ..||.|.....:::.:.|....::.    ..||:.:.  |..:.|:       ...::....:|:
Human   768 KLWDATSANERKSINVKQFFLNLED----PQEDMEVIVKCCSWSAD-------GARIMVAAKNKI 821

  Fly   156 KPDWISAIHVLRPMRRKDDVVLAITTTGTVKVWTLTGNENKHAEPIYENESKEIRCLNAITMNCC 220
               ::..||                |:|      |.|               ||...:..|:..|
Human   822 ---FLFDIH----------------TSG------LLG---------------EIHTGHHSTIQYC 846

  Fly   221 ---AQNQRTVLLV---CTKYWQIYDAGDFTVLCSVIAPARER--W--------QGGDFITS---D 266
               .||...|:.:   |.:.|.       |...|.:|..|..  |        .|..|:||   .
Human   847 DFSPQNHLAVVALSQYCVELWN-------TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQ 904

  Fly   267 RVMLWTDEGKGYLYKLPANCIPDNKEFHSKSVVRDAPYLYYVLQHAGDKVLSCP--PAMKLLQGA 329
            .:.||                 :.|:....|.|.....:..|.|.....||:..  ..::|:.|.
Human   905 TIRLW-----------------ETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGR 952

  Fly   330 GGQHNLLR------------------GDSEGYISVWNVPEVPLDNISILQAKQMPPRPLKPHVCT 376
            .||.:.|.                  ||..|.|.:     :.|.|..|.|::....:.:
Human   953 TGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEI-----LELVNNRIFQSRFQHKKTV------ 1006

  Fly   377 SLVEAWSIMDPPPVGILDQLSRITESPVKLTSSIYLPQQSRLVIGREDGSIVIVPATQTVMMQLL 441
                 |.|.                         :...:..|:...:|..|.:
Human  1007 -----WHIQ-------------------------FTADEKTLISSSDDAEIQV------------ 1029

  Fly   442 VGIKQNFSDWPSHQILY--GHRGRVN--CLLCPSMIHSRYEKSHLLSGGIDFAVCLWDLYSGSLL 502
                   .:|...:.::  ||:..|.  .||         :.|.|||...|..|.:|::.:|:..
Human  1030 -------WNWQLDKCIFLRGHQETVKDFRLL---------KNSRLLSWSFDGTVKVWNIITGNKE 1078

  Fly   503 HRFCVHAGEITQLLVPPESCSPRILKCICSVASDHSV------TLVSLQERK----CVTLASRHL 557
            ..|..|.|.:....:..::..      ..|.::|.:.      .|:.|.|.:    ||..::
Human  1079 KDFVCHQGTVLSCDISHDATK------FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA--- 1134

  Fly   558 FPVVTIKWRPLDDFLIVGCSDGSVYVWQMETGHLDRVLHGMLAEEVLSACDEQAEDGGSGGGG 620
            |.|.:       ..|..|..:|.:.:|.:..|            |:|..|...:|:|.:..||
Human  1135 FSVDS-------TLLATGDDNGEIRIWNVSNG------------ELLHLCAPLSEEGAATHGG 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbcn-3B	NP_001284797.1	WD40	<11..>204	CDD:225201	31/177 (18%)
		WD40 repeat	20..63	CDD:293791	8/34 (24%)
		WD40	<22..202	CDD:295369	31/175 (18%)
		WD40 repeat	68..107	CDD:293791	9/38 (24%)
		WD40 repeat	118..152	CDD:293791	4/35 (11%)
		WD40 repeat	160..204	CDD:293791	6/43 (14%)
		WD40 repeat	212..251	CDD:293791	9/44 (20%)
		WD40 repeat	406..459	CDD:293791	4/54 (7%)
		WD40	<449..>607	CDD:225201	33/171 (19%)
		WD40	453..>597	CDD:295369	30/157 (19%)
		WD40 repeat	513..555	CDD:293791	7/51 (14%)
		WD40 repeat	560..596	CDD:293791	6/35 (17%)
		WD40	<1395..>1469	CDD:225201
		WD40	<1399..1495	CDD:295369
		WD40 repeat	1439..1466	CDD:293791
APAF1	NP_863651.1	CARD_APAF1	7..92	CDD:260034
		NB-ARC	129..374	CDD:395745
		APAF1_C	453..587	CDD:407760
		WD40	607..910	CDD:238121	51/281 (18%)
		WD 1-1	613..652
		WD40 repeat	623..655	CDD:293791
		WD 1-2	655..694
		WD40 repeat	660..697	CDD:293791
		WD 1-3	697..738		8/31 (26%)
		WD40 repeat	703..741	CDD:293791	8/34 (24%)
		WD 1-4	741..780		11/41 (27%)
		WD40 repeat	746..791	CDD:293791	10/47 (21%)
		WD 1-5	796..836		11/86 (13%)
		WD40 repeat	802..870	CDD:293791	18/121 (15%)
		WD 1-6	838..877		9/45 (20%)
		WD 1-7	880..910		7/46 (15%)
		WD40 repeat	885..939	CDD:293791	12/70 (17%)
		Interpropeller linker. /evidence=ECO:0000250	910..921		2/10 (20%)
		WD 2-1	922..958		8/35 (23%)
		WD 2-2	959..998		8/43 (19%)
		WD40	961..1234	CDD:238121	51/315 (16%)
		WD40 repeat	964..990	CDD:293791	4/30 (13%)
		WD 2-3	1001..1040		6/93 (6%)
		WD40 repeat	1006..1030	CDD:293791	5/78 (6%)
		WD 2-4	1042..1080		13/46 (28%)
		WD40 repeat	1047..1082	CDD:293791	11/43 (26%)
		WD 2-5	1083..1122		6/44 (14%)
		WD40 repeat	1089..1124	CDD:293791	5/40 (13%)
		WD 2-6	1125..1164		11/60 (18%)
		WD40 repeat	1130..1172	CDD:293791	12/63 (19%)
		WD 2-7	1175..1212		2/4 (50%)
		WD40 repeat	1180..1213	CDD:293791
		WD 2-8	1213..1248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900