DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbcn-3B and wdr7

DIOPT Version :9

Sequence 1:	NP_001284797.1	Gene:	Rbcn-3B / 31155	FlyBaseID:	FBgn0023510	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_017946163.1	Gene:	wdr7 / 100036723	XenbaseID:	XB-GENE-951997	Length:	1526	Species:	Xenopus tropicalis

Alignment Length:	1638	Identity:	668/1638 - (40%)
Similarity:	960/1638 - (58%)	Gaps:	225/1638 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVSTNLVVPVVLWGPTAPTHCISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLKMSPRCLLVGHS 65
            |...:||:|:||||..|||||||:|.:.||..|:||||:|||||||.:.| .|:::||.||.||:
Frog     1 MAGNSLVLPIVLWGRKAPTHCISTVLVMDDLETIVTGCHDGQICLWDLSP-ELEINPRALLFGHT 64

  Fly    66 APVLCLVRASLLPENNFLVSSSENGEMCTWDLTDGKCMEAVKLPQVHTQIQSYH--TANSEDVRL 128
            |.:.||.:||...:..::||:||:||||.||:.||:|:|..||...||.||.|.  .....:.||
Frog    65 ASITCLSKASASSDRQYIVSASESGEMCLWDVNDGRCVEFTKLACTHTGIQFYQFSIGTPREGRL 129

  Fly   129 FCIGYYAEIMVMDPFSLEVIYVLSSKVKPDWISAIHVLRPMRRKDDVVLAITTTGTVKVWTLTGN 193
            .|.|:|.|::|||..||:|:|.|.||:.|||||::.::|..|.::|.|:|::.||.:|||.:|..
Frog   130 LCHGHYPEVLVMDASSLDVLYSLVSKISPDWISSMSIIRSHRTQEDTVVAVSVTGILKVWIITAE 194

  Fly   194 ENK--HAEPIYENESKEIRCLNAITMNCCAQNQRTVLLVCTKYWQIYDAGDFTVLCSVIAPARER 256
            .::  ..||::|.|||.|.|.|..:::.||..||::|:||:|||:::||||:::||||.:...:.
Frog   195 VHRMQDTEPVFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSVPSEEGQT 259

  Fly   257 WQGGDFITSDRVMLWTDEGKGYLYKLPANCIPDNKEFH---SKSVVRDAPYLYY----------- 307
            |.|||||::|:|::||::|:.::|||||:|||.:..|.   .|::....|.|.|
Frog   260 WTGGDFISADKVIVWTEDGQSFIYKLPASCIPASDTFRIDVGKAIENSIPPLLYSVMPKEDTQES 324

  Fly   308 ---------------------------VLQHA---GDKVLSCPPAMKLLQGAGGQ-HNLL-RGDS 340
                                       .|.|.   |..:|.|||..:...|.... |.|| :|||
Frog   325 HDVEALVQVPANEHPEQTITLGLYTPRTLFHTRPLGAILLICPPVTRFFYGRRKSFHKLLIQGDS 389

  Fly   341 EGYISVWNVPEVPLDNISILQAKQMPPRPLKPHVCTSLVEAWSIMDPPPVGILDQLSRITES--P 403
            .|.:.:|:||||    :...:.||    .|.....|||.||:..:.|.|.||:||||.:..|  |
Frog   390 SGRLCIWSVPEV----LEQPENKQ----GLGVTTTTSLQEAFDKLQPLPAGIIDQLSIMPNSKEP 446

  Fly   404 VKLTSSIYLPQQSRLVIGREDGSIVIVPATQTVMMQLLVGIKQNFSDWPSHQILYGHRGRVNCLL 468
            :|:|:|:|:|...|||.|||||||||||||||.::|||.|.......||.|:.|.|||.:|.|||
Frog   447 LKVTASVYIPSHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLL 511

  Fly   469 CPSMIHSRYEKSHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPESCSPRILKCICSV 533
            .|..:.|||::.:|:|||:||:|.:||::||.:.|.||||.||||||||||::||.|:..|||||
Frog   512 YPHQVSSRYDQRYLISGGVDFSVIVWDIFSGEMKHIFCVHGGEITQLLVPPDNCSTRVQHCICSV 576

  Fly   534 ASDHSVTLVSLQERKCVTLASRHLFPVVTIKWRPLDDFLIVGCSDGSVYVWQMETGHLDRVLHGM 598
            .|||||.::||:||||:.||||||||:..|||||.||:|:|||||||||||||:||.|||.:.|:
Frog   577 GSDHSVGILSLRERKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGI 641

  Fly   599 LAEEVLSACDEQAEDGGSGGGGGSNGASASEMGMANPAVHFFRGLKSRNMNAIR----HATQRGI 659
            .|.|:|:||||              ...|:...:::|||:..:.:..|::.|::    |..|...
Frog   642 TAVEILNACDE--------------AVPAAVDSLSHPAVNLKQAMTRRSLAALKTVAHHKLQTLA 692

  Fly   660 TQLQQLQGHNQGNFDFLMKHRSNPLVIQGLRTNPKDAESHILFFDIEGLIFELHSEEYAQMTPAT 724
            |.|...:..::||   |.|:..|.|.:|.::||..|::.|:||||:|.||.:|.:||.::...|.
Frog   693 TNLLASEASDKGN---LPKYSHNSLTVQAIKTNVTDSDIHLLFFDVEALIIQLLTEEASRPNTAL 754

  Fly   725 LESLGVHLQNPKDGKSMHLDASKKIGDFFNKVKNKAVDVEKILKDKDKHGLVQKFKEKTEIVEKK 789
            .....:...:....|.....|.|:....|.:||       :.:|:..|..|:....|..|.:.
Frog   755 TSPESLQKASGSSDKGGSFLAGKRAAVLFQQVK-------ETIKENIKEHLLDDEDEDEEAMR-- 810

  Fly   790 VQAKVESLQKAVEPHEEQQDLKSKIASKMEVTHVMEVAQLLLSLLHSWGLDPHLDKMCETRLGLL 854
                    ||..|...|.:..|||..:.:|....|:.|:|.:|.||:|||:..||.:|..|||:|
Frog   811 --------QKRDESDPEYRTSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNSALDDVCLERLGML 867

  Fly   855 RPIVPISYGVLSKAGYMSLLLPTW-QNNY-AIPPGIQLPSSSKKRPLPEELQRLEHLTAVFTSRL 917
            :|..|:|:|:||:.|:|||:||.: |..| |:...:.:   .:|..:.|.|           .:.
Frog   868 KPHCPVSFGLLSRGGHMSLMLPRFNQPVYKALDGNVGV---GRKMSVSEGL-----------GKG 918

  Fly   918 HWELSTTLTTNHILALVAMSNTLLSMSAASFL----------------PDSEKHK--------KL 958
            .:.:|..:||.|::::::::|||:||:.|:|:                |||.|.|        .:
Frog   919 TYGVSRAVTTQHLMSIISLANTLMSMTNATFIGDHMKKAPNRPPRSGSPDSMKGKASAQASSSMI 983

  Fly   959 Q---RLAQRTDSTLSNEEER--EELMAHHISQIKHAWSLLATHHCFLLPDKIEALEPKKFKRPQV 1018
            |   :.|...|::.|.|.:.  .:...|....:...||.||..||.:|||   .|...||:.|.:
Frog   984 QSQIKQAVAPDASASTEADHSASDRTLHSCFSVNEGWSQLAAMHCVMLPD---LLGLDKFRPPLL 1045

  Fly  1019 EMMVKRWQHHCIEIREAAQQILLGELTRMGKKGRKQLVESWAQYLPLYTHTEPIVGAQQQLALIS 1083
            ||:.:|||..|:|:|||||.:||.||.|:|::|||:.::|||.|||||..|            |.
Frog  1046 EMLARRWQDRCLEVREAAQALLLAELRRIGQEGRKETIDSWAPYLPLYVDT------------IM 1098

  Fly  1084 QPASGGAGSGSGGNGGVGVGVSGGGGAGSGSGPGGSVPGGDAHQDEDYEEEEEEI---------- 1138
            .|            |.....:..|..:...:|....|      |:|:.:..:::|
Frog  1099 SP------------GVTAENIQAGNASPDSAGSEAKV------QEEEQDLVDDDITAGCLSNVPP 1145

  Fly  1139 IRKPSSLSELKRKQTTAVILLGVIGAEFGQDISQESPNHRGSISMATGANLTSGVAGGERRKSSV 1203
            ::|.|...|.:|||.||::||.|||||||.:|  |.|.                :....|..|.:
Frog  1146 LKKASPSYEERRKQATAIVLLAVIGAEFGAEI--EPPK----------------LLTRPRSSSQI 1192

  Fly  1204 VEGFGIAN-----NLARLTSMALAHLLYAPPSPKLPQYTPLRRAAIDLLGRGFTVWEPYLDVSKV 1263
            .||||:.:     :|||.|..||..||..|||||||.::.:||.||||:||||||||||:|||.|
Frog  1193 PEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAV 1257

  Fly  1264 LLGLLEISCEG-KAVPNLNYKLPLTPQADACRTARHALRLIATARPAAFITTMAREVARYNTMQQ 1327
            |:||||:..:. |.:.|:...|||:|.||:.|:|||||.|||||||.|||||:|:||.|:..:..
Frog  1258 LMGLLELCADAEKQLANITIGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAA 1322

  Fly  1328 NAQS---INTPLTQSVLHKAKGEILQCVEMLIDKMQSEIAGLLVEVMDIALHCVDGNELKNRGLA 1389
            |.||   |:|    :.|.:||||||:.||:||:||.|::..||||||||.::|::|:.||.:||.
Frog  1323 NTQSQQNIHT----TALARAKGEILRVVEILIEKMPSDVVDLLVEVMDIIMYCLEGSLLKKKGLQ 1383

  Fly  1390 ELCPAICKFNQISHCAQTRRIAVGANSGNLAIYELRQNKCQMIPAHTHPITSLAFSPDGKYLVSY 1454
            |..|:||||..:|:|.::.||||||..|.:|:|::|..|||.|..|..||||::|:|||:||.:|
Frog  1384 ECFPSICKFYMVSYCERSHRIAVGARIGTVALYDIRTGKCQNIHGHKGPITSVSFAPDGRYLATY 1448

  Fly  1455 SCAENRLSFWQTSTGMFG-LGQ----SQTRCTKGYSTAPIPDVS--RLNPMRLAKLVWINNRTVT 1512
            |..::.:||||.:|.:.| :|.    .|.||.|.|...|:...|  .||.::||:|:|.:||.|.
Frog  1449 SNKDSHISFWQMNTSLLGSIGMLNSAPQLRCIKTYQVPPVQPASPGSLNALKLARLIWTSNRNVI 1513

  Fly  1513 LMLADGSETRFNV 1525
            ||..||.|.||.|
Frog  1514 LMAHDGKEHRFMV 1526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbcn-3B	NP_001284797.1	WD40	<11..>204	CDD:225201	94/196 (48%)
		WD40 repeat	20..63	CDD:293791	25/42 (60%)
		WD40	<22..202	CDD:295369	85/183 (46%)
		WD40 repeat	68..107	CDD:293791	18/38 (47%)
		WD40 repeat	118..152	CDD:293791	14/35 (40%)
		WD40 repeat	160..204	CDD:293791	15/45 (33%)
		WD40 repeat	212..251	CDD:293791	19/38 (50%)
		WD40 repeat	406..459	CDD:293791	30/52 (58%)
		WD40	<449..>607	CDD:225201	98/157 (62%)
		WD40	453..>597	CDD:295369	92/143 (64%)
		WD40 repeat	513..555	CDD:293791	28/41 (68%)
		WD40 repeat	560..596	CDD:293791	26/35 (74%)
		WD40	<1395..>1469	CDD:225201	37/73 (51%)
		WD40	<1399..1495	CDD:295369	43/102 (42%)
		WD40 repeat	1439..1466	CDD:293791	14/26 (54%)
wdr7	XP_017946163.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	482	1.000	Domainoid score	I405
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11408
Inparanoid	1	1.050	1161	1.000	Inparanoid score	I205
OMA	1	1.010	-	-		QHG55878
OrthoDB	1	1.010	-	-		D331603at33208
OrthoFinder	1	1.000	-	-		FOG0002541
OrthoInspector	1	1.000	-	-		oto104845
Panther	1	1.100	-	-	LDO	PTHR44099
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4239
SonicParanoid	1	1.000	-	-		X4954
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110