Protein Alignment Edem1 and MNL2

DIOPT Version :10

• Sequence 1: NP_001259152.1
• Gene: Edem1 / 31154
• FlyBaseID: FBgn0023511
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: NP_013158.1
• Gene: MNL2 / 850746
• SGDID: S000004047
• Length: 849
• Species: Saccharomyces cerevisiae
• Alignment Length: 833
• Identity: 162/833 - (19%)
• Similarity: 295/833 - (35%)
• Gaps: 267/833 - (32%)

  Fly    25 TGVSGQKQYSKARKLELREDVRRMFQHAYDGYLRHASNYDELRPLTCDGHDTWGSYSLTLIDALD 89
            |.:|....:.....::|..|| .|.:...|.:::..:....|.........||   .:.|||:||
Yeast   142 TSISQNDVHKIQPAMQLPPDV-DMIKQIKDIFMKSWNQEQLLLKSNLRRESTW---PIDLIDSLD 202

  Fly    90 TLATMGNFTEFRRAARLLEEKMDFDRDIN------VSVFETNIRIVGGLLSAHLLS--KRAGVEL 146
            ||...|....|:.:..::|   |||..:.      :.:.:...|::.|||||:.||  ||
Yeast   203 TLYLCGETKLFQDSVNIIE---DFDFRVPPLAMEVIDIPDITTRVLEGLLSAYELSMDKR----- 259

  Fly   147 EPGWPCKGPLLRLAEDVARRLLPAFVTNTGMPYGTVNLRY-------------GVPKGETSITCT 198
                     ||..|:.||..:|.:|.|...:|.    |:|             .||.|:.:
Yeast   260 ---------LLNKAKHVADFILRSFDTPNRIPI----LKYFWKSDLRNRFPDRTVPSGQLT---- 307

  Fly   199 AGVGTFLIEFGTLSRLTGKTIYEDVAMKAVHALWAYRSPIGLFGNHIDVQSGRWTALDSGIGAGV 263
                |..:.|..||:||....|.|    ||..::   :.|....|..|::......:|:   :|.
Yeast   308 ----TMALAFIRLSQLTRLNKYFD----AVERVF---TTIRQSYNEFDMEFMLPDVVDA---SGC 358

  Fly   264 DSLFEYLVKASVLLNRPELLELFHEARAAI--------------DKYMRKEDWYVWVGMNKGRVT 314
            ..|.:..::....|....:::..:|....:              |..::::..|....:|:  .|
Yeast   359 QLLTQEEIENGAHLKGSSIMKSINENFKFVHCQQLGKFLNPPIDDNSLQEQSQYQAYRINE--KT 421

  Fly   315 LPVFQSLEAFWPGILSIIGDTEPALRTISRYIGVWKKYGFLPEFYNIAAGEASPNREVYPLRPEL 379
            :|:.::|                           :|........|:|..| :|.|.....:.|.:
Yeast   422 VPILENL---------------------------FKINDLFQSSYDILDG-SSKNANAATMDPSI 458

  Fly   380 IESAMYLYRATGNEYLLEFGEHMLETLEFSAKTKCGYATIRNVVTHEKENRMESFFLAETSK-YL 443
                       |:|  :|..:.::|...|...||  ..:.:|.|..:.....::|.....|. :.
Yeast   459 -----------GSE--VEAVDEIIEKRNFKDGTK--KDSTKNTVGDKSLIDSQTFLTNSISNIFK 508

  Fly   444 YLLF----------DEENFLHNDGSGGELLSTEDDVCVVQAGAYIFNTEAHPMDMSALHCCH--- 495
            ::.|          .:.|||::..:..:.:.|.:::.|....:|         |:| |:.|.
Yeast   509 FMTFRPMLPKQTENKKFNFLNSILTKSQFMPTTNELDVTIRKSY---------DVS-LYSCRLGG 563

  Fly   496 --------AHNEDIYTSLDLQRFSPRAILERSK---KRQVAVQEQW---VPQ------CHPENNE 540
                    .|...:.|...|    |.::||.|:   :....:.|::   :||      |..|.|.
Yeast   564 ILGLSSRVPHRGGVNTKYIL----PSSLLEMSEIITESCFMLMEEFDGLLPQKFELDPCTDETNG 624

  Fly   541 --FFNKEDESVQAQDSEKEQEREQSGTSTTMAVDIEVFDEFQQPAGDLLVSNFEQIREERELNES 603
              .||.|.:|....:.|.|          |...|::|         .:.|||:.:...:::..
Yeast   625 NCEFNGETKSRMIANGEYE----------TFENDLDV---------GIKVSNYGKGGNDQKAK-- 668

  Fly   604 LHRNVVARNQLT---------------VSDLD-EFFAQRRESFASASEALNYVKT--FMG----- 645
              |||::::.:|               ::::| :...|.|..|....:...::.|  .||
Yeast   669 --RNVLSKDGITETQNIKGDTVGSSKSIAEIDGDEVTQIRRVFTLGKDIKPHITTDDTMGSQWKN 731

  Fly   646 --NYTMDVAFIRGLQLYDTNMSSVLG-----TGAQK-----------------EYESRMRTLWQL 686
              ::...|..:...:|.|:|:...:.     :|.||                 |..|..:.|||:
Yeast   732 HPDWPFWVNKVESRRLLDSNIIESIFYMYRISGEQKWRSMGKQSFGILMQELMELNSGAKGLWQI 796

  Fly   687 YELQQQYVANIRVIQGLG-----------LLTFPADGDRIPSHLTEVLDSLDK 728
            .|.   |....:|...|.           ||.| :|||::         ||||
Yeast   797 KEF---YENGEKVNNDLPSYWFSRTLKYYLLLF-SDGDKV---------SLDK 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Edem1	NP_001259152.1	Glyco_hydro_47	48..486	CDD:460241	91/483 (19%)
MNL2	NP_013158.1	Glyco_hydro_47	197..848	CDD:460241	152/774 (20%)