DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edem1 and si:ch211-282j22.3

DIOPT Version :9

Sequence 1:	NP_001259152.1	Gene:	Edem1 / 31154	FlyBaseID:	FBgn0023511	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_003200881.1	Gene:	si:ch211-282j22.3 / 562939	ZFINID:	ZDB-GENE-091113-49	Length:	837	Species:	Danio rerio

Alignment Length:	534	Identity:	209/534 - (39%)
Similarity:	296/534 - (55%)	Gaps:	67/534 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TLICAVLLVLLS-----------TGVSGQKQYSKARKLELREDVRRMFQHAYDGYLRHASNYDEL 66
            |..|..|:|.|:           :|..||.. :...|.|:|:.:..||.|||:.|:.:|...|||
Zfish    10 TRACGGLVVTLAALVISCPLAEVSGHDGQAM-TPEEKSEIRDQILEMFDHAYNSYMDYAYPADEL 73

  Fly    67 RPLTCDGH------------DTWGSYSLTLIDALDTLATMGNFTEFRRAARLLEEKMDFDRDINV 119
            .||:|.|.            |:.|.:||||||.||||..:....||..|.:.:...:..|.||.|
Zfish    74 MPLSCRGRVRGLEPNRGDVDDSLGKFSLTLIDTLDTLVLLNKLDEFEEAVKKIMRDVRLDNDIVV 138

  Fly   120 SVFETNIRIVGGLLSAHLLS---KRAGVELEPGWPCKGPLLRLAEDVARRLLPAFVTNTGMPYGT 181
            ||||||||::||||.||:::   |:.|..::  | .:..||.:|:::..||||||.|.:|:||..
Zfish   139 SVFETNIRVLGGLLGAHVMADVLKQRGQRMQ--W-YRDELLHMAKELGYRLLPAFNTTSGLPYPR 200

  Fly   182 VNLRYGVPK-----GETSITCTAGVGTFLIEFGTLSRLTGKTIYEDVAMKAVHALWAYRS-PIGL 240
            |||||||..     |..|.||||..||.::||..|||::|.||:|:.|.||:..||..|. ...|
Zfish   201 VNLRYGVVNPLSRTGTESDTCTACAGTLILEFAALSRMSGDTIFEEHARKAMDVLWEKRQRGSDL 265

  Fly   241 FGNHIDVQSGRWTALDSGIGAGVDSLFEYLVKASVLLNRPELLELFHEARAAIDKYMRKEDWYVW 305
            .|..|::.:|.|...|||:|||:||.:|||:||.:||.....||.|:...:||.||:.:....:.
Zfish   266 VGTVINIHNGDWVRRDSGVGAGIDSYYEYLMKAYILLGDKVYLERFNTHYSAIMKYISQPPLLLN 330

  Fly   306 VGMNKGRVTLPVF-QSLEAFWPGILSIIGDTEPALRTISRYIGVWKKYGFLPEFYNIAAGEASPN 369
            |.|:...|.:..: .||.||:||:..:.||.:||:.|......|.|::.||||.:..   |...:
Zfish   331 VHMHNPTVNVRSWMDSLLAFFPGLQVLRGDLKPAIETHEMLYQVTKQHNFLPEAFTT---EFRVH 392

  Fly   370 REVYPLRPELIESAMYLYRATGNEYLLEFGEHMLETLEFSAKTKCGYATIRNVVTHEKENRMESF 434
            ...:|||||..||..:||:|||:.|.|:.|:.::|.|...|:..||:|.:::|.|...|:||:||
Zfish   393 WGQHPLRPEFAESTYFLYKATGDPYYLKVGQSIVEKLNAHARVPCGFAAVQDVRTGTHEDRMDSF 457

  Fly   435 FLAETSKYLYLLFDEENFLHNDGSGGELLSTEDDVCVVQAGAYIFNTEAH--PMDMSALH--CC- 494
            ||||..|||||||.|::.|..|         .||        |||.||||  |:.:|...  |.
Zfish   458 FLAEMFKYLYLLFSEKSQLPID---------IDD--------YIFTTEAHLLPVSLSTTQPSCLT 505

  Fly   495 -----HAHNEDIYT 503
                 .||.:|:::
Zfish   506 NGTEPPAHQDDLFS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem1	NP_001259152.1	Glyco_hydro_47	48..486	CDD:279825	192/461 (42%)
si:ch211-282j22.3	XP_003200881.1	Glyco_hydro_47	55..494	CDD:279825	192/461 (42%)
si:ch211-282j22.3	XP_003200881.1	PA_EDEM3_like	642..768	CDD:239041
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D253774at33208
OrthoFinder	1	1.000	-	-		FOG0000713
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920