DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edem1 and EDEM2

DIOPT Version :9

Sequence 1:	NP_001259152.1	Gene:	Edem1 / 31154	FlyBaseID:	FBgn0023511	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_060687.2	Gene:	EDEM2 / 55741	HGNCID:	15877	Length:	578	Species:	Homo sapiens

Alignment Length:	561	Identity:	308/561 - (54%)
Similarity:	391/561 - (69%)	Gaps:	30/561 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PRNNGYPGTLICAVLLVLLSTGVSGQKQYSKARKLELREDVRRMFQHAYDGYLRHASNYDELRPL 69
            |:::|.||                  ...|.......||.|:.||.||||.||.:|..:||||||
Human    17 PQHHGAPG------------------PDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDELRPL 63

  Fly    70 TCDGHDTWGSYSLTLIDALDTLATMGNFTEFRRAARLLEEKMDFDRDINVSVFETNIRIVGGLLS 134
            ||||||||||:|||||||||||..:||.:||:|...:|::.:|||.|:|.||||||||:||||||
Human    64 TCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLS 128

  Fly   135 AHLLSKRAGVELEPGWPCKGPLLRLAEDVARRLLPAFVTNTGMPYGTVNLRYGVPKGETSITCTA 199
            ||||||:||||:|.||||.|||||:||:.||:|||||.|.||||||||||.:||..|||.:||||
Human   129 AHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTA 193

  Fly   200 GVGTFLIEFGTLSRLTGKTIYEDVAMKAVHALWAYRSPIGLFGNHIDVQSGRWTALDSGIGAGVD 264
            |:|||::||.|||.|||..::||||..|:..||..||.|||.||||||.:|:|.|.|:|||||||
Human   194 GIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVD 258

  Fly   265 SLFEYLVKASVLLNRPELLELFHEARAAIDKYMRKEDWYVWVGMNKGRVTLPVFQSLEAFWPGIL 329
            |.||||||.::||...:|:.:|.|...||..|.|.:|||:||.|.||.|::||||||||:|||:.
Human   259 SYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQ 323

  Fly   330 SIIGDTEPALRTISRYIGVWKKYGFLPEFYNIAAGEASPNREVYPLRPELIESAMYLYRATGNEY 394
            |:|||.:.|:||...|..|||::|.|||||||..|.....||.|||||||||||||||||||:..
Human   324 SLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPT 388

  Fly   395 LLEFGEHMLETLEFSAKTKCGYATIRNVVTHEKENRMESFFLAETSKYLYLLFDEENFLHNDGSG 459
            |||.|...:|::|..:|.:||:|||:::..|:.:|||||||||||.||||||||..||:||:||.
Human   389 LLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGST 453

  Fly   460 GELLSTEDDVCVVQAGAYIFNTEAHPMDMSALHCCHAHNEDIYTSLDLQR--FSPRAILERSK-- 520
            .:.:.|....|::.||.|||||||||:|.:|||||....|:.:...||.|  :|    |:||:
Human   454 FDAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYS----LKRSRSK 514

  Fly   521 -KRQVAVQEQWVPQCHPENNEFFNKEDESVQAQDSEKEQER 560
             ::.......|.|...|  ...|:.|:.. ||::.:..:::
Human   515 FQKNTVSSGPWEPPARP--GTLFSPENHD-QARERKPAKQK 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem1	NP_001259152.1	Glyco_hydro_47	48..486	CDD:279825	278/437 (64%)
EDEM2	NP_060687.2	Glyco_hydro_47	42..480	CDD:279825	278/437 (64%)
EDEM2	NP_060687.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..557		7/39 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	584	1.000	Domainoid score	I207
eggNOG	1	0.900	-	-		E1_KOG2429
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H10075
Inparanoid	1	1.050	611	1.000	Inparanoid score	I919
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D253774at33208
OrthoFinder	1	1.000	-	-		FOG0000713
OrthoInspector	1	1.000	-	-		oto88348
orthoMCL	1	0.900	-	-		OOG6_101442
Panther	1	1.100	-	-	LDO	PTHR45679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3607
SonicParanoid	1	1.000	-	-		X4562
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860