DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edem1 and alpha-Man-Ic

DIOPT Version :9

Sequence 1:	NP_001259152.1	Gene:	Edem1 / 31154	FlyBaseID:	FBgn0023511	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_733331.1	Gene:	alpha-Man-Ic / 318624	FlyBaseID:	FBgn0051202	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	134/509 - (26%)
Similarity:	226/509 - (44%)	Gaps:	105/509 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ELREDVRRMFQHAYDGYLRHASNYDELRPLTCDGH--DTWGSYSL--TLIDALDTLATMGNFTEF 100
            ::|..::.|..||:..|.|.....:|.||::...|  ..:.:|.|  |:|::||||..||...|.
  Fly    70 DMRAKIKEMMMHAWRNYARVVWGTNEFRPISRRVHFGGDFATYKLGATIIESLDTLHLMGLNKEL 134

  Fly   101 RRAARLLEEKMDFDR-DINVSVFETNIRIVGGLLSAHLLSKRAGVELEPGWPCKGPLLRL--AED 162
            ||:...:|:....|| |..:||:|...|::..:|:.:.|:              |..|.:  |..
  Fly   135 RRSRDWIEKSFHLDRVDEALSVYELTSRLLCPMLTLYSLT--------------GDSLYMDKAIH 185

  Fly   163 VARRLLPAFVTNTGMPYGTVNLRYGVPK-GET------SITCTAGVGTFLIEFGTLSRLTGKTIY 220
            :|.::||||.|.||:|     .|..||| |.|      .|:.|:..|:..:||..||.::|..:|
  Fly   186 IADKILPAFDTPTGIP-----RRLVVPKEGSTLTKYLSDISRTSEFGSLHLEFYYLSEVSGYPVY 245

  Fly   221 EDVAMKAVHALWAYRS-PIGLFGNHIDVQSGRWTALDSGIGAGVDSLFEYLVKASVLLNRPEL-- 282
            .: .:.|:..:.|..: |.||:.|....:.|:|    ......:..|::.|:|:.:...|.:.
  Fly   246 RE-RVDAIREILAKTTRPNGLYPNAYCTKFGKW----ENYNCSMHRLYDTLLKSWIQSGRTDTQN 305

  Fly   283 LELFHEARAAIDKYMRKEDWYVWVGMNKGRVT-LPVFQSLEAF--------WPGILSIIGDTEPA 338
            .:.|.||..|:.:.:        |.:|...|| :..|::...|        :.|.|.::|..|..
  Fly   306 ADTFKEAMLAVAQNL--------VVINPEDVTYVSTFRNGTLFHRMRHSDCFAGGLFVLGAAETQ 362

  Fly   339 LRTISRY--IGV----------WKK--------YGFLPEFYNIAAGEASP-NREVYPLRPELIES 382
            ::...:|  ||:          |..        :.|..|    :..|..| .|..|.||||:.|:
  Fly   363 MKHWEKYAHIGIGLTDTCHDSYWSSPTRLGPDTFAFTEE----SQQEIEPLQRNYYNLRPEVAET 423

  Fly   383 AMYLYRATGNEYLLEFGEHMLETLEFSAKTKCGYATIRNV--VTHEKENRMESFFLAETSKYLYL 445
            .:.|:|.|.:.....:|..|::.:|...:...||..:.:|  ||.|.::...||||..|.|||||
  Fly   424 YLVLWRITHHPQYRLWGLEMVQAIEKYCRMPYGYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYL 488

  Fly   446 LFDEENFLHNDGSGGELLSTEDDVCVVQAGAYIFNTEAHPMDMSALHCCH-AHN 498
            ||                 ::||  ||....::||:..|.:.:..::..: .||
  Fly   489 LF-----------------SDDD--VVSLEQWVFNSAGHFLPIKGVNPMYRQHN 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem1	NP_001259152.1	Glyco_hydro_47	48..486	CDD:279825	131/486 (27%)
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	131/488 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453090
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840