Protein Alignment Edem1 and Man1a2

DIOPT Version :10

• Sequence 1: NP_001259152.1
• Gene: Edem1 / 31154
• FlyBaseID: FBgn0023511
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: NP_034893.1
• Gene: Man1a2 / 17156
• MGIID: 104676
• Length: 641
• Species: Mus musculus
• Alignment Length: 506
• Identity: 168/506 - (33%)
• Similarity: 248/506 - (49%)
• Gaps: 82/506 - (16%)

  Fly    26 GVSGQKQYSKARKLEL---REDVRRMFQHAYDGYLRHASNYDELRPLTCDGHDT--WGSYSL--T 83
            ||||    .....:|:   |:.::.|.:||:|.|..:...::||||:...||.|  :||..:  |
Mouse   166 GVSG----GDPEDMEIKKKRDKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSTNIFGSSQMGAT 226

  Fly    84 LIDALDTLATMGNFTEFRRAARLLEEKMDFDRDINVSVFETNIRIVGGLLSAHLLSKRAGVELEP 148
            ::||||||..||...||....|.:||.:||..:..|||||.|||.:||||:|:.||   |.|:
Mouse   227 IVDALDTLYIMGLHDEFMDGQRWIEENLDFSVNSEVSVFEVNIRFIGGLLAAYYLS---GEEI-- 286

  Fly   149 GWPCKGPLLRLAEDVARRLLPAFVTNTGMPYGTVNLRYGVPK----GETSITCTAGVGTFLIEFG 209
               .|...::|||    :|||||.|.||:|:..|||:.||.:    .....:..|..||..:||.
Mouse   287 ---FKTKAVQLAE----KLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFV 344

  Fly   210 TLSRLTGKTIYEDVAMKAVHALWAYRSPIGLFGNHIDVQSGRWTALDSGIGAGVDSLFEYLVKAS 274
            .||.|||...|.:..|.....|.....|.||:.|:::.::|||....:.:|...||.:|||:||.
Mouse   345 HLSYLTGDLTYYNKVMHIRKLLQKMERPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAW 409

  Fly   275 VLLNRPELLELFHEAR-------AAIDKYMRKED--WYVWVGMNKGRVTLPVFQSLEAFWPGILS 330
            ::.::.:     ||||       .||:|::.|:.  ..|::|..|..........|..|..|:.:
Mouse   410 LMSDKTD-----HEARRMYDDAVEAIEKHLIKKSRGGLVFIGEWKNGHLERKMGHLACFAGGMFA 469

  Fly   331 IIGD--------------TEPALRTISRYIGVWKKYGFLPEFYNI-AAGEASPNREV---YPLRP 377
            :..|              .|.|......|.....|.|  ||.:.. .|.||...|:.   |.|||
Mouse   470 LGADGSRKDKAGHYLELGAEIARTCHESYDRTALKLG--PESFKFDGAVEAVAVRQAEKYYILRP 532

  Fly   378 ELIESAMYLYRATGNEYLLEFGEHMLETLEFSAKTKCGYATIRNVV--THEKENRMESFFLAETS 440
            |:||:..||:|.|.:....::|......:|.|.:...|::.:::|.  |...::..:|||||||.
Mouse   533 EVIETYWYLWRFTHDPRYRQWGWEAALAIEKSCRVSGGFSGVKDVYAPTPVHDDVQQSFFLAETL 597

  Fly   441 KYLYLLFDEENFLHNDGSGGELLSTEDDVCVVQAGAYIFNTEAHPMDMSAL 491
            |||||||          ||.:||..:.         ::|||||||:.:..|
Mouse   598 KYLYLLF----------SGDDLLPLDH---------WVFNTEAHPLPVLRL 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Edem1	NP_001259152.1	Glyco_hydro_47	48..486	CDD:460241	160/474 (34%)
Man1a2	NP_034893.1	PTZ00121	<109..208	CDD:173412	14/45 (31%)
		Glyco_hydro_47	187..626	CDD:460241	161/476 (34%)