DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mip130 and lin9

DIOPT Version :9

Sequence 1:	NP_569958.2	Gene:	mip130 / 31153	FlyBaseID:	FBgn0023509	Length:	986	Species:	Drosophila melanogaster
Sequence 2:	NP_001038411.1	Gene:	lin9 / 560867	ZFINID:	ZDB-GENE-030131-1747	Length:	543	Species:	Danio rerio

Alignment Length:	642	Identity:	198/642 - (30%)
Similarity:	289/642 - (45%)	Gaps:	160/642 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 NIINDDKPLRMSLAPKKTPGRPPQSAGGGSSQKIPLTPSKVLKK--------RKGVVSRYMRSSE 207
            |.:|:...|     ||.      |:..|.||.....||::..|:        .:.:.||..|.|:
Zfish    27 NTLNEKNNL-----PKS------QTTRGRSSYVSMETPTRSSKRSRLSCEDEERPIASRSPRRSQ 80

  Fly   208 QGTNSVSASNQPQLLGKHKKATPSKSQSVGSKLGSGGPKTGRGAHFIGKGTAAAVAAVAAAEEEA 272
            :.|      ..||.|  ...|||
Zfish    81 RVT------TMPQKL--TNVATP------------------------------------------ 95

  Fly   273 NQAEAAALANKRLGQSIGLRLRNLLKLPKAHKWAIAEWFYSYVDKPLFECRDEFMNHVNELAPRL 337
                     :||:.|.|||||||||||||||||.|.|||||.:|:||||..::|...:.|..|.|
Zfish    96 ---------DKRVSQKIGLRLRNLLKLPKAHKWCIYEWFYSNIDRPLFEGDNDFCLCLKESFPNL 151

  Fly   338 GTRSLIRHEWVNIRRRMGRPRRCSAKFFSEERKELDRKRQVIRTLQSRKPGEFKDSVSMLSDMPE 402
            .||.|.|.||..|||.||:|||||:.||:|||..|.:|||.:|.||.||..:    :|:..|:|:
Zfish   152 KTRKLTRVEWGTIRRLMGKPRRCSSAFFAEERMALKQKRQKMRLLQQRKITD----MSLCKDLPD 212

  Fly   403 KIPMTLPLGTKVTARLRSPQDGIFAGTVAAYDSLNAMYRVTFERIGLGTHAIPDYEIVSENFHEM 467
            :||:.|.:|||||||||...||:|.|.:.|.|:..|.|||||:|.|||||.:||||::|...||.
Zfish   213 EIPLPLVIGTKVTARLRGVHDGLFTGQIDAVDTSAATYRVTFDRNGLGTHTVPDYEVLSNEPHET 277

  Fly   468 LPLHSFTKDFRPNLMSIYQTNNLGFTTNLGFTANLTNNYLQKKEKIDGGAGAAAGAGSLYFKPQK 532
            :|:.:|.:..||.....:.|...|..|  |.|.::
Zfish   278 MPISAFAQKQRPPRFQNFLTPPRGSYT--GSTQSI------------------------------ 310

  Fly   533 HLATNNAAARNALSMKLNKSDPLLGQDSVGVSPIRQQLTRN-----RGYSTSLLEHLVRLEKYIA 592
                            |..:|||..|     ||.|.:||..     .|:....|..:.||.|.:.
Zfish   311 ----------------LMDNDPLFSQ-----SPWRSKLTGTDGETLGGFPVKFLVQVTRLSKILM 354

  Fly   593 VKADRIQRLNKMNGTAELAMGDMISHDENGDRHRRQIAVNFQRQYAFNIVTIERINAELMFELTK 657
            :|.:.|:.|.:||..||....           :...|.::.|::||..::.:|::|.:|...|.:
Zfish   355 IKKEHIKHLKEMNTEAEKLKS-----------YSMPIGLDLQKRYATTVLDLEQLNKDLNKVLHE 408

  Fly   658 VQELSSSLTRNPNVQAMISPTYLREECRAKASQTVDDIN-----KGMVKNTRMIKLLKDLTTLLI 717
            ||:....|..:..:|....|:.||..|..::...:...|     :..|:||.:.:|:..||.||:
Zfish   409 VQQFCFELAPDQGMQPADQPSELRRRCEEESQDVLRQNNTLASGEPRVQNTELTQLISRLTALLL 473

  Fly   718 VTQNL--GGDCEVSEVNEVLEGCLEEVRSNLICSENREVFQMSVQGRLEYIAMDISR 772
            ..:.|  |||....|...:.:. |.:::|: |...|...||.:|:..:.:|...:|:
Zfish   474 QIRCLAEGGDLNSFEFKSLTDS-LNDIKSS-IDDSNLSCFQDNVEIHVAHIQSGLSQ 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mip130	NP_569958.2	DIRP	311..419	CDD:284095	55/107 (51%)
lin9	NP_001038411.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..82		16/65 (25%)
lin9	NP_001038411.1	DIRP	125..229	CDD:284095	55/107 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574086
Domainoid	1	1.000	111	1.000	Domainoid score	I6229
eggNOG	1	0.900	-	-		E1_KOG1019
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35252
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3067
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279992at33208
OrthoFinder	1	1.000	-	-		FOG0005813
OrthoInspector	1	1.000	-	-		oto40167
orthoMCL	1	0.900	-	-		OOG6_106727
Panther	1	1.100	-	-	LDO	PTHR21689
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2615
SonicParanoid	1	1.000	-	-		X4787
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.830